P96936 (Y647_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein Rv0647c/MT0675

Gene names

Ordered Locus Names:	Rv0647c, MT0675
ORF Names:	MTCY20H10.28c

Organism

Mycobacterium tuberculosis [Reference proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	488 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the protein kinase superfamily. ADCK protein kinase family.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cell wall Inferred from direct assay PubMed 15525680. Source: MTBBASE cytosol Inferred from direct assay PubMed 15525680. Source: MTBBASE plasma membrane Inferred from direct assay PubMed 14532352. Source: MTBBASE
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro protein kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 488	488	Uncharacterized protein Rv0647c/MT0675		PRO_0000200735
Experimental info
	Sequence conflict	18 – 27	10	VTQQVSGLTF → AYPASERAHV in CAB07127. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P96936 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: C84762E31FE495D0	FASTA	488	54,803
	10 20 30 40 50 60 MRAEIGPDFR PHYTFGDVTQ QVSGLTFNWE LSAPVWHTAQ MGSTTHREVA KLDRVPLPVE 70 80 90 100 110 120 AARVAATGWQ VTRTAVRFIG RLPRKGPWQQ KVIKELPQTF ADLGPTYVKF GQIIASSPGA 130 140 150 160 170 180 FGESLSREFR GLLDRVPPAK TDEVHKLFVE ELGDEPARLF ASFEEEPFAS ASIAQVHYAT 190 200 210 220 230 240 LRSGEEVVVK IQRPGIRRRV AADLQILKRF AQTVELAKLG RRLSAQDVVA DFADNLAEEL 250 260 270 280 290 300 DFRLEAQSME AWVSHLHASP LGKNIRVPQV HWDFTTERVL TMERVHGIRI DNAAAIRKAG 310 320 330 340 350 360 FDGVELVKAL LFSVFEGGLR HGLFHGDLHA GNLYVDEAGR IVFFDFGIMG RIDPRTRWLL 370 380 390 400 410 420 RELVYALLVK KDHAAAGKIV VLMGAVGTMK PETQAAKDLE RFATPLTMQS LGDMSYADIG 430 440 450 460 470 480 RQLSALADAY DVKLPRELVL IGKQFLYVER YMKLLAPRWQ MMSDPQLTGY FANFMVEVSR EHQSDIEV

References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842574 Genomic DNA. Translation: CAB07127.1. AE000516 Genomic DNA. Translation: AAK44901.1.
PIR	D70614.
RefSeq	NP_215161.1. NC_000962.3. NP_335087.1. NC_002755.2. YP_006513988.1. NC_018143.1.
3D structure databases
ProteinModelPortal	P96936.
SMR	P96936. Positions 321-354.
ModBase	Search...
Protein-protein interaction databases
STRING	83332.Rv0647c.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK44901; AAK44901; MT0675.
GeneID	13318533. 888070. 925959.
KEGG	mtc:MT0675. mtu:Rv0647c. mtv:RVBD_0647c.
PATRIC	18123207. VBIMycTub22151_0733.
Organism-specific databases
TubercuList	Rv0647c.
Phylogenomic databases
eggNOG	COG0661.
HOGENOM	HOG000043480.
OMA	WNFTSER.
ProtClustDB	CLSK790653.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR004147. UbiB_dom. [Graphical view]
Pfam	PF03109. ABC1. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Y647_MYCTU

Accession

Primary (citable) accession number: P96936

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 1, 1997
Last modified:	May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program