Skip Header

Contribute Send feedback
Read comments (?) or add your own

P96885 (PCC5_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable propionyl-CoA carboxylase beta chain 5
Short name=PCCase
EC=6.4.1.3
Alternative name(s):
Propanoyl-CoA:carbon dioxide ligase
Gene names
Name:accD5
Synonyms:pccB
Ordered Locus Names:Rv3280, MT3379.1
ORF Names:MTCY71.20
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length548 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.

Pathway

Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.

Subunit structure

Probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits By similarity.

Sequence similarities

Belongs to the AccD/PCCB family.

Contains 1 carboxyltransferase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 548548Probable propionyl-CoA carboxylase beta chain 5
PRO_0000199799

Regions

Domain31 – 540510Carboxyltransferase

Experimental info

Sequence conflict3451D → G in AAK47722. Ref.2

Secondary structure

1 .......................................................................................... 548
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P96885 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: A1C4C382ABBE3FAE

FASTA54859,354
        10         20         30         40         50         60 
MTSVTDRSAH SAERSTEHTI DIHTTAGKLA ELHKRREESL HPVGEDAVEK VHAKGKLTAR 

        70         80         90        100        110        120 
ERIYALLDED SFVELDALAK HRSTNFNLGE KRPLGDGVVT GYGTIDGRDV CIFSQDATVF 

       130        140        150        160        170        180 
GGSLGEVYGE KIVKVQELAI KTGRPLIGIN DGAGARIQEG VVSLGLYSRI FRNNILASGV 

       190        200        210        220        230        240 
IPQISLIMGA AAGGHVYSPA LTDFVIMVDQ TSQMFITGPD VIKTVTGEEV TMEELGGAHT 

       250        260        270        280        290        300 
HMAKSGTAHY AASGEQDAFD YVRELLSYLP PNNSTDAPRY QAAAPTGPIE ENLTDEDLEL 

       310        320        330        340        350        360 
DTLIPDSPNQ PYDMHEVITR LLDDEFLEIQ AGYAQNIVVG FGRIDGRPVG IVANQPTHFA 

       370        380        390        400        410        420 
GCLDINASEK AARFVRTCDC FNIPIVMLVD VPGFLPGTDQ EYNGIIRRGA KLLYAYGEAT 

       430        440        450        460        470        480 
VPKITVITRK AYGGAYCVMG SKDMGCDVNL AWPTAQIAVM GASGAVGFVY RQQLAEAAAN 

       490        500        510        520        530        540 
GEDIDKLRLR LQQEYEDTLV NPYVAAERGY VDAVIPPSHT RGYIGTALRL LERKIAQLPP 


KKHGNVPL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842582 Genomic DNA. Translation: CAB07063.1.
AE000516 Genomic DNA. Translation: AAK47722.1.
PIRA70980.
RefSeqNP_217797.1. NC_000962.2.
NP_337908.1. NC_002755.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2A7SX-ray2.90A/B/C/D/E/F1-548[»]
2BZRX-ray2.20A/B/C/D/E/F1-548[»]
ProteinModelPortalP96885.
SMRP96885. Positions 20-548.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-3982419.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000003904; EBMYCP00000003904; EBMYCG00000003902.
EBMYCT00000070754; EBMYCP00000068813; EBMYCG00000070749.
GeneID888725.
922476.
GenomeReviewsGene locus MT3379.1 in contig AE000516_GR.
Gene locus Rv3280 in contig AL123456_GR.
KEGGmtc:MT3379.1.
mtu:Rv3280.
PATRIC18129184. VBIMycTub22151_3688.
TIGRMT3379.1.

Organism-specific databases

TubercuListRv3280.

Phylogenomic databases

GeneTreeEBGT00050000015716.
HOGENOMHBG461319.
OMAGASTHTR.
PhylomeDBP96885.
ProtClustDBCLSK792402.

Enzyme and pathway databases

BioCycMetaCyc:RV3280-MONOMER.

Family and domain databases

InterProIPR000022. Carboxyl_trans.
IPR011763. COA_CT_C.
IPR011762. COA_CT_N.
[Graphical view]
KOK01966.
PfamPF01039. Carboxyl_trans. 1 hit.
[Graphical view]
PROSITEPS50989. COA_CT_CTER. 1 hit.
PS50980. COA_CT_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePCC5_MYCTU
AccessionPrimary (citable) accession number: P96885
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1997
Last modified: January 25, 2012
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents