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Protein

HTH-type transcriptional repressor KstR

Gene

kstR

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Controls the expression of genes used for utilizing diverse lipids as energy sources.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi59 – 7820H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: MTBBASE
  • protein homodimerization activity Source: MTBBASE

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciMTBRV:RV3574-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor KstR
Gene namesi
Name:kstR
Ordered Locus Names:Rv3574
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv3574.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220HTH-type transcriptional repressor KstRPRO_0000405028Add
BLAST

Proteomic databases

PaxDbiP96856.
PRIDEiP96856.

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: MTBBASE

Protein-protein interaction databases

STRINGi83332.Rv3574.

Structurei

Secondary structure

1
220
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi33 – 5725Combined sources
Helixi60 – 678Combined sources
Helixi71 – 777Combined sources
Helixi81 – 9919Combined sources
Helixi103 – 1053Combined sources
Helixi110 – 12617Combined sources
Helixi129 – 14113Combined sources
Helixi144 – 1463Combined sources
Helixi147 – 16519Combined sources
Beta strandi166 – 1694Combined sources
Helixi172 – 19322Combined sources
Helixi199 – 21416Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3MNLX-ray1.80A/B22-220[»]
5CW8X-ray2.60A/B22-220[»]
5CXGX-ray2.10A/B/C/D20-220[»]
5CXIX-ray2.00A/B22-220[»]
ProteinModelPortaliP96856.
SMRiP96856. Positions 30-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 9661HTH tetR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108SGK. Bacteria.
ENOG4111HR8. LUCA.
HOGENOMiHOG000052226.
InParanoidiP96856.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P96856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSANTNTSS APDAPPRAVM KVAVLAESEL GSEAQRERRK RILDATMAIA
60 70 80 90 100
SKGGYEAVQM RAVADRADVA VGTLYRYFPS KVHLLVSALG REFSRIDAKT
110 120 130 140 150
DRSAVAGATP FQRLNFMVGK LNRAMQRNPL LTEAMTRAYV FADASAASEV
160 170 180 190 200
DQVEKLIDSM FARAMANGEP TEDQYHIARV ISDVWLSNLL AWLTRRASAT
210 220
DVSKRLDLAV RLLIGDQDSA
Length:220
Mass (Da):24,050
Last modified:January 7, 2015 - v5
Checksum:i085E69F84C6982C6
GO

Sequence cautioni

The sequence CCP46397.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP46397.1. Different initiation.
PIRiD70606.
RefSeqiNP_218091.3. NC_000962.3.

Genome annotation databases

EnsemblBacteriaiCCP46397; CCP46397; Rv3574.
GeneIDi887204.
KEGGimtu:Rv3574.
PATRICi18156563. VBIMycTub87468_3991.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP46397.1. Different initiation.
PIRiD70606.
RefSeqiNP_218091.3. NC_000962.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3MNLX-ray1.80A/B22-220[»]
5CW8X-ray2.60A/B22-220[»]
5CXGX-ray2.10A/B/C/D20-220[»]
5CXIX-ray2.00A/B22-220[»]
ProteinModelPortaliP96856.
SMRiP96856. Positions 30-218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv3574.

Proteomic databases

PaxDbiP96856.
PRIDEiP96856.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP46397; CCP46397; Rv3574.
GeneIDi887204.
KEGGimtu:Rv3574.
PATRICi18156563. VBIMycTub87468_3991.

Organism-specific databases

TubercuListiRv3574.

Phylogenomic databases

eggNOGiENOG4108SGK. Bacteria.
ENOG4111HR8. LUCA.
HOGENOMiHOG000052226.
InParanoidiP96856.

Enzyme and pathway databases

BioCyciMTBRV:RV3574-MONOMER.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37Rv.
  2. "A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis."
    Kendall S.L., Withers M., Soffair C.N., Moreland N.J., Gurcha S., Sidders B., Frita R., Ten Bokum A., Besra G.S., Lott J.S., Stoker N.G.
    Mol. Microbiol. 65:684-699(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A TRANSCRIPTIONAL REPRESSOR, SUBUNIT.
    Strain: ATCC 25618 / H37Rv.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ATCC 25618 / H37Rv.

Entry informationi

Entry nameiKSTR_MYCTU
AccessioniPrimary (citable) accession number: P96856
Secondary accession number(s): L0TEJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: January 7, 2015
Last modified: May 11, 2016
This is version 106 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.