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Protein

HTH-type transcriptional repressor KstR

Gene

kstR

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Controls the expression of genes used for utilizing diverse lipids as energy sources.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi59 – 78H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-7852-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor KstR
Gene namesi
Name:kstR
Ordered Locus Names:Rv3574
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv3574.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004050281 – 220HTH-type transcriptional repressor KstRAdd BLAST220

Proteomic databases

PaxDbiP96856.

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: MTBBASE

Protein-protein interaction databases

STRINGi83332.Rv3574.

Structurei

Secondary structure

1220
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi33 – 57Combined sources25
Helixi60 – 67Combined sources8
Helixi71 – 77Combined sources7
Helixi81 – 99Combined sources19
Helixi103 – 105Combined sources3
Helixi110 – 126Combined sources17
Helixi129 – 141Combined sources13
Helixi144 – 146Combined sources3
Helixi147 – 165Combined sources19
Beta strandi166 – 169Combined sources4
Helixi172 – 193Combined sources22
Helixi199 – 214Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MNLX-ray1.80A/B22-220[»]
5AQCX-ray1.66A/B23-220[»]
5CW8X-ray2.60A/B22-220[»]
5CXGX-ray2.10A/B/C/D20-220[»]
5CXIX-ray2.00A/B22-220[»]
ProteinModelPortaliP96856.
SMRiP96856.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 96HTH tetR-typePROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108SGK. Bacteria.
ENOG4111HR8. LUCA.
HOGENOMiHOG000052226.
InParanoidiP96856.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P96856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSANTNTSS APDAPPRAVM KVAVLAESEL GSEAQRERRK RILDATMAIA
60 70 80 90 100
SKGGYEAVQM RAVADRADVA VGTLYRYFPS KVHLLVSALG REFSRIDAKT
110 120 130 140 150
DRSAVAGATP FQRLNFMVGK LNRAMQRNPL LTEAMTRAYV FADASAASEV
160 170 180 190 200
DQVEKLIDSM FARAMANGEP TEDQYHIARV ISDVWLSNLL AWLTRRASAT
210 220
DVSKRLDLAV RLLIGDQDSA
Length:220
Mass (Da):24,050
Last modified:January 7, 2015 - v5
Checksum:i085E69F84C6982C6
GO

Sequence cautioni

The sequence CCP46397 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP46397.1. Different initiation.
PIRiD70606.
RefSeqiNP_218091.3. NC_000962.3.

Genome annotation databases

EnsemblBacteriaiCCP46397; CCP46397; Rv3574.
GeneIDi887204.
KEGGimtu:Rv3574.
PATRICi18156563. VBIMycTub87468_3991.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP46397.1. Different initiation.
PIRiD70606.
RefSeqiNP_218091.3. NC_000962.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MNLX-ray1.80A/B22-220[»]
5AQCX-ray1.66A/B23-220[»]
5CW8X-ray2.60A/B22-220[»]
5CXGX-ray2.10A/B/C/D20-220[»]
5CXIX-ray2.00A/B22-220[»]
ProteinModelPortaliP96856.
SMRiP96856.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv3574.

Proteomic databases

PaxDbiP96856.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP46397; CCP46397; Rv3574.
GeneIDi887204.
KEGGimtu:Rv3574.
PATRICi18156563. VBIMycTub87468_3991.

Organism-specific databases

TubercuListiRv3574.

Phylogenomic databases

eggNOGiENOG4108SGK. Bacteria.
ENOG4111HR8. LUCA.
HOGENOMiHOG000052226.
InParanoidiP96856.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-7852-MONOMER.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKSTR_MYCTU
AccessioniPrimary (citable) accession number: P96856
Secondary accession number(s): L0TEJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: January 7, 2015
Last modified: November 30, 2016
This is version 110 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.