P96834 (P96834_MYCTU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
NAD(P) transhydrogenase, beta subunit EMBL AAK44388.1
EC=1.6.1.1 EMBL AAK44388.1

Submitted name:
PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT BETA) PNTB [INTEGRAL MEMBRANE PROTEIN] (PYRIDINE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT BETA) (NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT BETA) EMBL CAB07033.1
EC=1.6.1.1 EMBL CAB07033.1

Gene names

Name:	pntB EMBL CAB07033.1
Ordered Locus Names:	MT0165, Rv0157

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	475 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane By similarity. PIRNR PIRNR000204
Catalytic activity	NADPH + NAD+ = NADP+ + NADH. PIRNR PIRNR000204
Sequence similarities	Belongs to the PNT beta subunit family. PIRNR PIRNR000204

Ontologies

Keywords
Cellular component	Cell inner membrane PIRNR PIRNR000204 Cell membrane Membrane
Ligand	NAD PIRNR PIRNR000204 NADP PIRNR PIRNR000204
Molecular function	Oxidoreductase PIRNR PIRNR000204 EMBL CAB07033.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to plasma membrane Inferred from direct assay. Source: MTBBASE
Molecular function	NAD(P)+ transhydrogenase (AB-specific) activity Inferred from electronic annotation. Source: EC NADP binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	P96834 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 65131735A90D9F02	FASTA	475	48,858
	10 20 30 40 50 60 MNLHYLVEIL YIISFSLFIY GLMGLTGPKT AVRGNLIAAA GMTIAVAATL VMIRHTSQWP 70 80 90 100 110 120 LIIAGLVVGV VLGVPPARLT KMTAMPQLVA FFNGVGGGTV ALIALSEFID TTGFSAFQHG 130 140 150 160 170 180 ESPTVHIVVA SLFAAIIGSI SFWGSIVAFG KLQEIISGRP IGLGKAQQPI NLLLLAVAVA 190 200 210 220 230 240 AAVVIGLHAH PGSGGVALWW MIGLLVAAGV LGLMVVLPIG GADMPVVISM LNAMTGLSAA 250 260 270 280 290 300 AAGLALNNTA MIVAGMIVGA SGSILTNLMA KAMNRSIPAI VAGGFGGGGV APSGGGDDKH 310 320 330 340 350 360 VKATSAADAA IQMAYANQVI VVPGYGLAVA QAQHAVKDLA TLLEDRGVPV KYAIHPVAGR 370 380 390 400 410 420 MPGHMNVLLA EAEVDYDAMK DMDDINDEFA RTDVTIVIGA NDVTNPAARN ETSSPIYGMP 430 440 450 460 470 ILNVDKSRSV IVLKRSMNSG FAGIDNPLFY ADGTTMLFGD AKKSVTEVSE ELKAL

References

[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[2]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J., DeBoy R., Dodson R., Gwinn M., Haft D., Hickey E., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M., Salzberg S.L., Delcher A., Utterback T. , Weidman J., Khouri H., Gill J., Mikula A., Bishai W., Jacobs Jr W.R. Jr, Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000516 Genomic DNA. Translation: AAK44388.1. BX842572 Genomic DNA. Translation: CAB07033.1.
PIR	H70618.
RefSeq	NP_214671.1. NC_000962.2. NP_334574.1. NC_002755.2.
3D structure databases
HSSP	HSSP built from PDB template 1NM5 based on UniProtKB Q59765.
ProteinModelPortal	P96834.
SMR	P96834. Positions 301-472.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000001025; EBMYCP00000001025; EBMYCG00000001025. EBMYCT00000069446; EBMYCP00000067505; EBMYCG00000069441.
GeneID	886830. 923039.
GenomeReviews	Gene locus MT0165 in contig AE000516_GR. Gene locus Rv0157 in contig AL123456_GR.
KEGG	mtc:MT0165. mtu:Rv0157.
PATRIC	18122093. VBIMycTub22151_0181.
TIGR	MT0165.
Organism-specific databases
TubercuList	Rv0157.
Phylogenomic databases
GeneTree	EBGT00050000016832.
HOGENOM	HBG648813.
OMA	MEDINPE.
PhylomeDB	P96834.
ProtClustDB	CLSK790309.
Family and domain databases
InterPro	IPR012136. NADH_DH_b. [Graphical view]
KO	K00325.
Pfam	PF02233. PNTB. 1 hit. [Graphical view]
PIRSF	PIRSF000204. PNTB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

P96834_MYCTU

Accession

Primary (citable) accession number: P96834
Secondary accession number(s): Q7DAD2

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1997
Last sequence update:	May 1, 1997
Last modified:	January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)