P96830 (P96830_MYCTU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) EMBL CAB07057.1
EC=3.1.3.48 EMBL CAB07057.1

Gene names

Name:	ptbB EMBL CAB07057.1
Ordered Locus Names:	MT0162, Rv0153c

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Molecular function	Hydrolase EMBL CAB07057.1
Technical term	3D-structure PDB 1YWF PDB 2OZ5 Complete proteome Reference proteome
Gene Ontology (GO)
Uncategorized	inositol or phosphatidylinositol phosphatase activity Inferred from direct assay. Source: MTBBASE
Biological process	growth of symbiont in host cell Inferred from direct assay. Source: MTBBASE pathogenesis Inferred from direct assay. Source: MTBBASE
Cellular component	extracellular region Inferred from direct assay. Source: MTBBASE
Molecular function	protein serine/threonine phosphatase activity Inferred from direct assay. Source: MTBBASE protein tyrosine phosphatase activity Inferred from direct assay. Source: MTBBASE
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	P96830 [UniParc]. Last modified August 1, 1998. Version 2. Checksum: 2794F56866D2E432	FASTA	276	30,154
	10 20 30 40 50 60 MAVRELPGAW NFRDVADTAT ALRPGRLFRS SELSRLDDAG RATLRRLGIT DVADLRSSRE 70 80 90 100 110 120 VARRGPGRVP DGIDVHLLPF PDLADDDADD SAPHETAFKR LLTNDGSNGE SGESSQSIND 130 140 150 160 170 180 AATRYMTDEY RQFPTRNGAQ RALHRVVTLL AAGRPVLTHC FAGKDRTGFV VALVLEAVGL 190 200 210 220 230 240 DRDVIVADYL RSNDSVPQLR ARISEMIQQR FDTELAPEVV TFTKARLSDG VLGVRAEYLA 250 260 270 AARQTIDETY GSLGGYLRDA GISQATVNRM RGVLLG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[2]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J., DeBoy R., Dodson R., Gwinn M., Haft D., Hickey E., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M., Salzberg S.L., Delcher A., Utterback T. , Weidman J., Khouri H., Gill J., Mikula A., Bishai W., Jacobs Jr W.R. Jr, Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
[3]	"Mycobacterium tuberculosis protein tyrosine phosphatase PtpB structure reveals a diverged fold and a buried active site." Grundner C., Ng H.L., Alber T. Structure 13:1625-1634(2005) [PubMed: 16271885] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.71 ANGSTROMS).
[4]	"Structural basis for selective inhibition of Mycobacterium tuberculosis protein tyrosine phosphatase PtpB." Grundner C., Perrin D., Hooft van Huijsduijnen R., Swinnen D., Gonzalez J., Gee C.L., Wells T.N., Alber T. Structure 15:499-509(2007) [PubMed: 17437721] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000516 Genomic DNA. Translation: AAK44386.1.
BX842572 Genomic DNA. Translation: CAB07057.1.

PIR

D70618.

RefSeq

NP_214667.1. NC_000962.2.
NP_334572.1. NC_002755.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1YWF	X-ray	1.71	A	1-276	[»]
2OZ5	X-ray	2.00	A/B	1-276	[»]

ProteinModelPortal

P96830.

SMR

P96830. Positions 4-276.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBMYCT00000000892; EBMYCP00000000892; EBMYCG00000000892.
EBMYCT00000070343; EBMYCP00000068402; EBMYCG00000070338.

GeneID

886842.
923036.

GenomeReviews

Gene locus MT0162 in contig AE000516_GR.
Gene locus Rv0153c in contig AL123456_GR.

KEGG

mtc:MT0162.
mtu:Rv0153c.

PATRIC

18122083. VBIMycTub22151_0176.

TIGR

MT0162.

Organism-specific databases

TubercuList

Rv0153c.

Phylogenomic databases

GeneTree

EBGT00050000015825.

HOGENOM

HBG702284.

OMA

RNWLQAT.

ProtClustDB

CLSK790305.

Family and domain databases

InterPro

IPR000387. Tyr/Dual-specificity_Pase.
[Graphical view]

KO

K01104.

PROSITE

PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

P96830_MYCTU

Accession

Primary (citable) accession number: P96830
Secondary accession number(s): Q7DAD4

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1997
Last sequence update:	August 1, 1998
Last modified:	December 14, 2011
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)