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Protein

Putative short-chain type dehydrogenase/reductase Rv0148

Gene

Rv0148

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei151 – 1511SubstrateBy similarity
Active sitei164 – 1641Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 3525NAD or NADPBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • protein pupylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciMTBRV:RV0148-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative short-chain type dehydrogenase/reductase Rv0148 (EC:1.1.1.-)
Gene namesi
Ordered Locus Names:Rv0148
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0148.

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • plasma membrane Source: MTBBASE
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Putative short-chain type dehydrogenase/reductase Rv0148PRO_0000395884Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki280 – 280Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein pup)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP96825.
PRIDEiP96825.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0148.

Structurei

3D structure databases

ProteinModelPortaliP96825.
SMRiP96825. Positions 7-279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105KF3. Bacteria.
COG1028. LUCA.
InParanoidiP96825.
OMAiHFRENGF.
PhylomeDBiP96825.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P96825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGVQDRVIV VTGAGGGLGR EYALTLAGEG ASVVVNDLGG ARDGTGAGSA
60 70 80 90 100
MADEVVAEIR DKGGRAVANY DSVATEDGAA NIIKTALDEF GAVHGVVSNA
110 120 130 140 150
GILRDGTFHK MSFENWDAVL KVHLYGGYHV LRAAWPHFRE QSYGRVVVAT
160 170 180 190 200
STSGLFGNFG QTNYGAAKLG LVGLINTLAL EGAKYNIHAN ALAPIAATRM
210 220 230 240 250
TQDILPPEVL EKLTPEFVAP VVAYLCTEEC ADNASVYVVG GGKVQRVALF
260 270 280
GNDGANFDKP PSVQDVAARW AEITDLSGAK IAGFKL
Length:286
Mass (Da):29,779
Last modified:July 5, 2004 - v3
Checksum:i84D8E05D8461BAEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP42873.1.
PIRiG70617.
RefSeqiNP_214662.1. NC_000962.3.
WP_003400979.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP42873; CCP42873; Rv0148.
GeneIDi886845.
KEGGimtu:Rv0148.
PATRICi18148830. VBIMycTub87468_0168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP42873.1.
PIRiG70617.
RefSeqiNP_214662.1. NC_000962.3.
WP_003400979.1. NZ_KK339370.1.

3D structure databases

ProteinModelPortaliP96825.
SMRiP96825. Positions 7-279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0148.

Proteomic databases

PaxDbiP96825.
PRIDEiP96825.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP42873; CCP42873; Rv0148.
GeneIDi886845.
KEGGimtu:Rv0148.
PATRICi18148830. VBIMycTub87468_0168.

Organism-specific databases

TubercuListiRv0148.

Phylogenomic databases

eggNOGiENOG4105KF3. Bacteria.
COG1028. LUCA.
InParanoidiP96825.
OMAiHFRENGF.
PhylomeDBiP96825.

Enzyme and pathway databases

BioCyciMTBRV:RV0148-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiY0148_MYCTU
AccessioniPrimary (citable) accession number: P96825
Secondary accession number(s): L0T4I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.