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Protein
Submitted name:

Probable transcriptional regulatory protein (Possibly TetR-family)

Gene

Rv0144

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Probable transcriptional regulatory protein (Possibly TetR-family)Imported
Gene namesi
Ordered Locus Names:Rv0144Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0144.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MTBBASE
  • plasma membrane Source: MTBBASE
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiP96821.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0144.

Structurei

3D structure databases

ProteinModelPortaliP96821.
SMRiP96821. Positions 84-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini87 – 14761HTH tetR-type DNA-bindingInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105JEX. Bacteria.
COG1309. LUCA.
HOGENOMiHOG000053730.
OMAiGATFQAI.
OrthoDBiEOG67DPRF.
PhylomeDBiP96821.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P96821-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHSWTPTSV MTPPLVVAAF RPVGHYRLAT DRAGGPCSPP ATGAKLTSSV
60 70 80 90 100
ASRPTVGTKP QWWHTLVMSM SLTAGRGPGR PPAAKADETR KRILHAARQV
110 120 130 140 150
FSERGYDGAT FQEIAVRADL TRPAINHYFA NKRVLYQEVV EQTHELVIVA
160 170 180 190 200
GIERARREPT LMGRLAVVVD FAMEADAQYP ASTAFLATTV LESQRHPELS
210 220 230 240 250
RTENDAVRAT REFLVWAVND AIERGELAAD VDVSSLAETL LVVLCGVGFY
260 270 280
IGFVGSYQRM ATITDSFQQL LAGTLWRPPT
Length:280
Mass (Da):30,643
Last modified:July 1, 1997 - v2
Checksum:iD4AD7BCC1BB75D1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP42869.1.
RefSeqiNP_214658.1. NC_000962.3.
WP_003400961.1. NC_000962.3.

Genome annotation databases

EnsemblBacteriaiCCP42869; CCP42869; Rv0144.
GeneIDi886854.
KEGGimtu:Rv0144.
mtv:RVBD_0144.
PATRICi18122061. VBIMycTub22151_0165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP42869.1.
RefSeqiNP_214658.1. NC_000962.3.
WP_003400961.1. NC_000962.3.

3D structure databases

ProteinModelPortaliP96821.
SMRiP96821. Positions 84-247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0144.

Proteomic databases

PaxDbiP96821.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP42869; CCP42869; Rv0144.
GeneIDi886854.
KEGGimtu:Rv0144.
mtv:RVBD_0144.
PATRICi18122061. VBIMycTub22151_0165.

Organism-specific databases

TubercuListiRv0144.

Phylogenomic databases

eggNOGiENOG4105JEX. Bacteria.
COG1309. LUCA.
HOGENOMiHOG000053730.
OMAiGATFQAI.
OrthoDBiEOG67DPRF.
PhylomeDBiP96821.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37RvImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiP96821_MYCTU
AccessioniPrimary (citable) accession number: P96821
Secondary accession number(s): F2GLU1, I6Y2W6, Q7DAE2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: July 1, 1997
Last modified: July 6, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.