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P96803 (G6PI_MYCSM) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
OrganismMycobacterium smegmatis
Taxonomic identifier1772 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Sequence caution

The sequence AAB52545.1 differs from that shown. Reason: Frameshift at position 101.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 549549Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180676

Sites

Active site3531Proton donor By similarity
Active site3841 By similarity
Active site5101 By similarity

Sequences

Sequence LengthMass (Da)Tools
P96803 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: EC850980E57EF9BC

FASTA54959,673
        10         20         30         40         50         60 
MSADITETPA WQALSDHHAE IGDRHLTELF ADDPARGTEL ALTVGDLYID YSKHRVTRRT 

        70         80         90        100        110        120 
LDLLVDLARA AGLEERRDAM FAGEHINTSE DRAVLHTALR LPRDAKLVVD GQDVVADVHD 

       130        140        150        160        170        180 
VLDRMGDFTD RLRSGEWTGA TGERITTVVN IGIGGSDLGP VMVYDALRHY ADAGISARFV 

       190        200        210        220        230        240 
SNVDPADLVA KLDGLEPAKT LFIVASKTFS TLETLTNATA ARRWLTDALG DAAVAKHSSR 

       250        260        270        280        290        300 
CPPTRSWSTK FGINTDNMFG FWDWVGGRYS VDSAIGLSVM AVIGKERFAE FLAGFHIVDE 

       310        320        330        340        350        360 
HFRTAPLHQN APALLGLIGL WYSNFFGAQS RAVLPYSNDL SRFAAYLQQL TMESNGKSVR 

       370        380        390        400        410        420 
ADGTPVSTDT GEIFWGEPGT NGQHAFYQLL HQGTRLVPAD FIGFSQPTDD LPTADGTGSM 

       430        440        450        460        470        480 
HDLLMSNFFA QTQVLAFGKT ADAIASEGTP ADVVPHKVMP GNRPTTSILA TKLTPSVVGQ 

       490        500        510        520        530        540 
LIALYEHQVF TEGVIWGIDS FDQWGVELGK TQAKALLPVL TGDKSPAAQS DTSTDALVRR 


YRTERGRPA 

« Hide

References

[1]"Interruption of the phosphoglucose isomerase gene results in glucose auxotrophy in Mycobacterium smegmatis."
Tuckman D., Donnelly R.J., Zhao F.X., Jacobs W.R. Jr., Connell N.D.
J. Bacteriol. 179:2724-2730(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: mc(2)743.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U88433 Genomic DNA. Translation: AAB52545.1. Frameshift.

3D structure databases

ProteinModelPortalP96803.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_MYCSM
AccessionPrimary (citable) accession number: P96803
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 17, 2006
Last modified: June 11, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways