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P96803

- G6PI_MYCSM

UniProt

P96803 - G6PI_MYCSM

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Mycobacterium smegmatis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei353 – 3531Proton donorBy similarity
    Active sitei384 – 3841By similarity
    Active sitei510 – 5101By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Alternative name(s):
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphohexose isomerase
    Short name:
    PHI
    Gene namesi
    Name:pgi
    OrganismiMycobacterium smegmatis
    Taxonomic identifieri1772 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 549549Glucose-6-phosphate isomerasePRO_0000180676Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP96803.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P96803-1 [UniParc]FASTAAdd to Basket

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    MSADITETPA WQALSDHHAE IGDRHLTELF ADDPARGTEL ALTVGDLYID    50
    YSKHRVTRRT LDLLVDLARA AGLEERRDAM FAGEHINTSE DRAVLHTALR 100
    LPRDAKLVVD GQDVVADVHD VLDRMGDFTD RLRSGEWTGA TGERITTVVN 150
    IGIGGSDLGP VMVYDALRHY ADAGISARFV SNVDPADLVA KLDGLEPAKT 200
    LFIVASKTFS TLETLTNATA ARRWLTDALG DAAVAKHSSR CPPTRSWSTK 250
    FGINTDNMFG FWDWVGGRYS VDSAIGLSVM AVIGKERFAE FLAGFHIVDE 300
    HFRTAPLHQN APALLGLIGL WYSNFFGAQS RAVLPYSNDL SRFAAYLQQL 350
    TMESNGKSVR ADGTPVSTDT GEIFWGEPGT NGQHAFYQLL HQGTRLVPAD 400
    FIGFSQPTDD LPTADGTGSM HDLLMSNFFA QTQVLAFGKT ADAIASEGTP 450
    ADVVPHKVMP GNRPTTSILA TKLTPSVVGQ LIALYEHQVF TEGVIWGIDS 500
    FDQWGVELGK TQAKALLPVL TGDKSPAAQS DTSTDALVRR YRTERGRPA 549
    Length:549
    Mass (Da):59,673
    Last modified:October 17, 2006 - v2
    Checksum:iEC850980E57EF9BC
    GO

    Sequence cautioni

    The sequence AAB52545.1 differs from that shown. Reason: Frameshift at position 101.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U88433 Genomic DNA. Translation: AAB52545.1. Frameshift.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U88433 Genomic DNA. Translation: AAB52545.1 . Frameshift.

    3D structure databases

    ProteinModelPortali P96803.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Interruption of the phosphoglucose isomerase gene results in glucose auxotrophy in Mycobacterium smegmatis."
      Tuckman D., Donnelly R.J., Zhao F.X., Jacobs W.R. Jr., Connell N.D.
      J. Bacteriol. 179:2724-2730(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: mc(2)743.

    Entry informationi

    Entry nameiG6PI_MYCSM
    AccessioniPrimary (citable) accession number: P96803
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3