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P96794 (HPRT_MYCAV) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hypoxanthine-guanine phosphoribosyltransferase

Short name=HGPRT
Short name=HGPRTase
EC=2.4.2.8
Gene names
Name:hpt
Synonyms:hprT
OrganismMycobacterium avium
Taxonomic identifier1764 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

Protein attributes

Sequence length203 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.

GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.

Cofactor

Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein By similarity.

Pathway

Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 203203Hypoxanthine-guanine phosphoribosyltransferase
PRO_0000139607

Regions

Nucleotide binding122 – 13110IMP By similarity
Nucleotide binding181 – 1822IMP By similarity

Sites

Active site1261Proton acceptor By similarity
Metal binding1821Magnesium By similarity
Binding site1541IMP By similarity
Binding site1761IMP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
P96794 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: C0E30AEC38F7F086

FASTA20322,329
        10         20         30         40         50         60 
MGVAQISSAI TPAQPAELYP GDIKSVLLTA EQIQARIAEL GREIGDNYRD AAAETGQDLL 

        70         80         90        100        110        120 
LITVLKGAVI FVTDLARAIP LPTQFEFMAV SSYGSSTSSS GVVRILKDLD RDIQGRDVLI 

       130        140        150        160        170        180 
VEDVVDSGLT LSWLLRNLST RHPRSLRVCT LLRKPDARGA HVDIAYVGFD IPNDFVVGYG 

       190        200 
LDYDERYRDL SYIGTLDPRV YQQ 

« Hide

References

[1]Bergeson S.E., Barry R., Allen T., Hwang H., Ullman B.
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U88875 Genomic DNA. Translation: AAB48623.1.

3D structure databases

ProteinModelPortalP96794.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0634.

Enzyme and pathway databases

UniPathwayUPA00591; UER00648.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
InterProIPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
TIGRFAMsTIGR01203. HGPRTase. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHPRT_MYCAV
AccessionPrimary (citable) accession number: P96794
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: May 1, 1997
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways