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Reviewed, UniProtKB/Swiss-Prot P96789 (6PGD_LACLM)

Last modified November 25, 2008. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    6-phosphogluconate dehydrogenase, decarboxylating
    EC=1.1.1.44
Gene names
Name: gnd
Ordered Locus Names: llmg_0586
OrganismLactococcus lactis subsp. cremoris (strain MG1363) [Complete proteome] [HAMAP]
Taxonomic identifier416870 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

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Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Catalytic activity

6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4724726-phosphogluconate dehydrogenase, decarboxylating
PRO_0000090046

Experimental info

Sequence conflict431Y → F in AAC12804. Ref.1

Secondary structure

1 ..................................................................... 472
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P96789-1 [UniParc].

Last modified May 1, 2007. Version 3.
Checksum: A0075C9F46171F1C

FASTA47252,460
        10         20         30         40         50         60 
MAQANFGVVG MAVMGKNLAL NVESRGYTVA IYNRTTSKTE EVYKEHQDKN LVFTKTLEEF 

        70         80         90        100        110        120 
VGSLEKPRRI MLMVQAGAAT DATIKSLLPL LDIGDILIDG GNTHFPDTMR RNAELADSGI 

       130        140        150        160        170        180 
NFIGTGVSGG EKGALLGPSM MPGGQKEAYD LVAPIFEQIA AKAPQDGKPC VAYMGANGAG 

       190        200        210        220        230        240 
HYVKMVHNGI EYGDMQLIAE SYDLLKRILG LSNAEIQAIF EEWNEGELDS YLIEITKEVL 

       250        260        270        280        290        300 
KRKDDEGEGY IVDKILDKAG NKGTGKWTSE SALDLGVPLP LITESVFARY ISTYKDERVK 

       310        320        330        340        350        360 
ASKVLSGPAL DFSGDKKEVI EKIRKALYFS KIMSYAQGFA QLRKASEEFD WDLPYGTIAQ 

       370        380        390        400        410        420 
IWRAGCIIRA EFLQNITDAF DKDSELENLL LDDYFVDITK RYQEAVRDVV SLAVQAGTPI 

       430        440        450        460        470 
PTFTSAISYY DSYRSENLPA NLIQAQRDYF GAHTYERTDK AGIFHYDWYT ED

« Hide

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References

« Hide 'large scale' references
[1]"6-phosphogluconate dehydrogenase from Lactococcus lactis: a role for arginine residues in binding substrate and coenzyme."
Tetaud E., Hanau S., Wells J.M., Le Page R.W.F., Adams M.J., Arkison S., Barrett M.P.
Biochem. J. 338:55-60(1999) [PubMed: 9931298] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete genome sequence of the lactic acid bacterial paradigm Lactococcus lactis subsp. cremoris MG1363."
Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C., Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P., van Sinderen D., Kok J.
J. Bacteriol. 189:3256-3270(2007) [PubMed: 17307855] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

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Cross-references

Sequence databases

U74322 Genomic DNA. Translation: AAC12804.1.
AM406671 Genomic DNA. Translation: CAL97186.1.
RefSeqYP_001031931.1.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2IYOX-ray2.40A1-472[»]
2IYPX-ray2.79A/B/C1-472[»]
2IZ0X-ray2.60A/B/C1-472[»]
2IZ1X-ray2.30A/B/C1-472[»]
ModBaseSearch...

Genome annotation databases

GeneID4798708.
GenomeReviewsGene locus llmg_0586 in contig AM406671_GR.
KEGGllm:llmg_0586.

Organism-specific databases

CMRSearch...

Family and domain databases

InterProIPR006183. 6-phosphogluconate_DHase.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NAD-bd.
IPR006184. 6PGdom_BS.
IPR013328. DHase_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PRINTSPR00076. 6PGDHDRGNASE.
TIGRFAMsTIGR00873. gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry name6PGD_LACLM
AccessionPrimary (citable) accession number: P96789
Secondary accession number(s): A2RIU0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 2007
Last modified: November 25, 2008
This is version 60 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents