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P96786

- FLID_HELPY

UniProt

P96786 - FLID_HELPY

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Protein
Flagellar hook-associated protein 2
Gene
fliD, HP_0752
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. Essential to colonize and establish infection in gastric mucosa as a result of its essential role in motility. Has effect on flaA gene transcription.

GO - Biological processi

  1. bacterial-type flagellum-dependent swarming motility Source: CACAO
  2. cell adhesion Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellar hook-associated protein 2
Short name:
HAP2
Alternative name(s):
Filament cap protein
Flagellar cap protein
Gene namesi
Name:fliD
Ordered Locus Names:HP_0752
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. bacterial-type flagellum Source: CACAO
  2. bacterial-type flagellum hook Source: InterPro
  3. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Bacterial flagellum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 685684Flagellar hook-associated protein 2
PRO_0000177019Add
BLAST

Interactioni

Subunit structurei

Homopentamer By similarity.

Protein-protein interaction databases

DIPiDIP-3401N.
IntActiP96786. 1 interaction.
MINTiMINT-176105.
STRINGi85962.HP0752.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili618 – 64730 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the FliD family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG1345.
KOiK02407.
OMAiTRPTNEV.
OrthoDBiEOG6GN6X6.

Family and domain databases

InterProiIPR010809. FliD_C.
IPR003481. FliD_N.
[Graphical view]
PfamiPF07195. FliD_C. 1 hit.
PF02465. FliD_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P96786-1 [UniParc]FASTAAdd to Basket

« Hide

MAIGSLSSLG LGSKVLNYDV IDKLKDADEK ALIAPLDKKM EQNVEKQKAL    50
VEIKTLLSAL KGPVKTLSDY STYISRKSNV TGDALSASVG VGVPIQDIKV 100
DVQNLAQGDI NELGAKFSSR DDIFSQVDTT LKFYTQNKDY AVNIKAGMTL 150
GDVAQSITDA TNGEVMGIVM KTGGNDPYQL MVNTKNTGED NRVYFGSHLQ 200
STLTNKNALS LGVDGSGKSE VSLNLKGADG NMHEVPIMLE LPESASIKQK 250
NTAIQKAMEQ ALENDPNFKN LIANGDISID TLHGGESLII NDRRGGNIEV 300
KGSKAKELGF LQTTTQESDL LKSSRTIKEG KLEGVVSLNG QKLDLSALTK 350
ESNTSEENTD AIIQAINAKE GLSAFKNAEG KLVINSKTGM LTIKGEDALG 400
KASLKDLGLN AGMVQSYEAS QNTLFMSKNL QKASDSAFTY NGVSITRPTN 450
EVNDVISGVN ITLEQTTEPN KPAIISVSRD NQAIIDSLTE FVKAYNELIP 500
KLDEDTRYDA DTKIAGIFNG VGDIRAIRSS LNNVFSYSVH TDNGVESLMK 550
YGLSLDDKGV MSLDEAKLSS ALNSNPKATQ DFFYGSDSKD MGGREIHQEG 600
IFSKFNQVIA NLIDGGNAKL KIYEDSLDRD AKSLTKDKEN AQELLKTRYN 650
IMAERFAAYD SQISKANQKF NSVQMMIDQA AAKKN 685
Length:685
Mass (Da):74,131
Last modified:January 23, 2007 - v4
Checksum:i12D4F56473D047F6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591A → S in strain: KCTC 0217BP.
Natural varianti86 – 861S → N in strain: KCTC 0217BP.
Natural varianti91 – 911V → A in strain: KCTC 0217BP.
Natural varianti193 – 1931V → I in strain: KCTC 0217BP.
Natural varianti231 – 2311N → S in strain: KCTC 0217BP.
Natural varianti258 – 2581M → I in strain: KCTC 0217BP.
Natural varianti270 – 2701N → D in strain: KCTC 0217BP.
Natural varianti363 – 3631I → V in strain: KCTC 0217BP.
Natural varianti368 – 3681A → S in strain: KCTC 0217BP.
Natural varianti373 – 3731S → N in strain: KCTC 0217BP.
Natural varianti422 – 4221N → G in strain: KCTC 0217BP.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti654 – 68532ERFAA…AAKKN → DVLPLMIAKSLKPIKNSIPC K in AAD07800. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82981 Genomic DNA. Translation: AAC35999.1.
AE000511 Genomic DNA. Translation: AAD07800.1.
PIRiH64613.
RefSeqiNP_207545.1. NC_000915.1.
YP_006934668.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07800; AAD07800; HP_0752.
GeneIDi13869937.
900004.
KEGGiheo:C694_03870.
hpy:HP0752.
PATRICi20592793. VBIHelPyl33062_0785.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82981 Genomic DNA. Translation: AAC35999.1 .
AE000511 Genomic DNA. Translation: AAD07800.1 .
PIRi H64613.
RefSeqi NP_207545.1. NC_000915.1.
YP_006934668.1. NC_018939.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3401N.
IntActi P96786. 1 interaction.
MINTi MINT-176105.
STRINGi 85962.HP0752.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07800 ; AAD07800 ; HP_0752 .
GeneIDi 13869937.
900004.
KEGGi heo:C694_03870.
hpy:HP0752.
PATRICi 20592793. VBIHelPyl33062_0785.

Phylogenomic databases

eggNOGi COG1345.
KOi K02407.
OMAi TRPTNEV.
OrthoDBi EOG6GN6X6.

Family and domain databases

InterProi IPR010809. FliD_C.
IPR003481. FliD_N.
[Graphical view ]
Pfami PF07195. FliD_C. 1 hit.
PF02465. FliD_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of the Helicobacter pylori fliD gene, an essential factor in flagellar structure and motility."
    Kim J.S., Chang J.H., Chung S.I., Yum J.S.
    J. Bacteriol. 181:6969-6976(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-16, CHARACTERIZATION.
    Strain: KCTC 0217BP.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiFLID_HELPY
AccessioniPrimary (citable) accession number: P96786
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 85 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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