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P96786 (FLID_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Flagellar hook-associated protein 2

Short name=HAP2
Alternative name(s):
Filament cap protein
Flagellar cap protein
Gene names
Name:fliD
Ordered Locus Names:HP_0752
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length685 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. Essential to colonize and establish infection in gastric mucosa as a result of its essential role in motility. Has effect on flaA gene transcription.

Subunit structure

Homopentamer By similarity.

Subcellular location

Secreted. Bacterial flagellum.

Sequence similarities

Belongs to the FliD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 685684Flagellar hook-associated protein 2
PRO_0000177019

Regions

Coiled coil618 – 64730 Potential

Natural variations

Natural variant591A → S in strain: KCTC 0217BP.
Natural variant861S → N in strain: KCTC 0217BP.
Natural variant911V → A in strain: KCTC 0217BP.
Natural variant1931V → I in strain: KCTC 0217BP.
Natural variant2311N → S in strain: KCTC 0217BP.
Natural variant2581M → I in strain: KCTC 0217BP.
Natural variant2701N → D in strain: KCTC 0217BP.
Natural variant3631I → V in strain: KCTC 0217BP.
Natural variant3681A → S in strain: KCTC 0217BP.
Natural variant3731S → N in strain: KCTC 0217BP.
Natural variant4221N → G in strain: KCTC 0217BP.

Experimental info

Sequence conflict654 – 68532ERFAA…AAKKN → DVLPLMIAKSLKPIKNSIPC K in AAD07800. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P96786 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: 12D4F56473D047F6

FASTA68574,131
        10         20         30         40         50         60 
MAIGSLSSLG LGSKVLNYDV IDKLKDADEK ALIAPLDKKM EQNVEKQKAL VEIKTLLSAL 

        70         80         90        100        110        120 
KGPVKTLSDY STYISRKSNV TGDALSASVG VGVPIQDIKV DVQNLAQGDI NELGAKFSSR 

       130        140        150        160        170        180 
DDIFSQVDTT LKFYTQNKDY AVNIKAGMTL GDVAQSITDA TNGEVMGIVM KTGGNDPYQL 

       190        200        210        220        230        240 
MVNTKNTGED NRVYFGSHLQ STLTNKNALS LGVDGSGKSE VSLNLKGADG NMHEVPIMLE 

       250        260        270        280        290        300 
LPESASIKQK NTAIQKAMEQ ALENDPNFKN LIANGDISID TLHGGESLII NDRRGGNIEV 

       310        320        330        340        350        360 
KGSKAKELGF LQTTTQESDL LKSSRTIKEG KLEGVVSLNG QKLDLSALTK ESNTSEENTD 

       370        380        390        400        410        420 
AIIQAINAKE GLSAFKNAEG KLVINSKTGM LTIKGEDALG KASLKDLGLN AGMVQSYEAS 

       430        440        450        460        470        480 
QNTLFMSKNL QKASDSAFTY NGVSITRPTN EVNDVISGVN ITLEQTTEPN KPAIISVSRD 

       490        500        510        520        530        540 
NQAIIDSLTE FVKAYNELIP KLDEDTRYDA DTKIAGIFNG VGDIRAIRSS LNNVFSYSVH 

       550        560        570        580        590        600 
TDNGVESLMK YGLSLDDKGV MSLDEAKLSS ALNSNPKATQ DFFYGSDSKD MGGREIHQEG 

       610        620        630        640        650        660 
IFSKFNQVIA NLIDGGNAKL KIYEDSLDRD AKSLTKDKEN AQELLKTRYN IMAERFAAYD 

       670        680 
SQISKANQKF NSVQMMIDQA AAKKN 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of the Helicobacter pylori fliD gene, an essential factor in flagellar structure and motility."
Kim J.S., Chang J.H., Chung S.I., Yum J.S.
J. Bacteriol. 181:6969-6976(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-16, CHARACTERIZATION.
Strain: KCTC 0217BP.
[2]"The complete genome sequence of the gastric pathogen Helicobacter pylori."
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. expand/collapse author list , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.
Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700392 / 26695.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U82981 Genomic DNA. Translation: AAC35999.1.
AE000511 Genomic DNA. Translation: AAD07800.1.
PIRH64613.
RefSeqNP_207545.1. NC_000915.1.
YP_006934668.1. NC_018939.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3401N.
IntActP96786. 1 interaction.
MINTMINT-176105.
STRING85962.HP0752.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07800; AAD07800; HP_0752.
GeneID13869937.
900004.
KEGGheo:C694_03870.
hpy:HP0752.
PATRIC20592793. VBIHelPyl33062_0785.

Phylogenomic databases

eggNOGCOG1345.
KOK02407.
OMAFAAYDSQ.
OrthoDBEOG6GN6X6.
ProtClustDBPRK08453.

Family and domain databases

InterProIPR010809. FliD_C.
IPR003481. FliD_N.
[Graphical view]
PfamPF07195. FliD_C. 1 hit.
PF02465. FliD_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFLID_HELPY
AccessionPrimary (citable) accession number: P96786
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 13, 2013
This is version 81 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names