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Protein

Flagellar hook-associated protein 2

Gene

fliD

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. Essential to colonize and establish infection in gastric mucosa as a result of its essential role in motility. Has effect on flaA gene transcription.

GO - Biological processi

  • bacterial-type flagellum-dependent swarming motility Source: CACAO
  • cell adhesion Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellar hook-associated protein 2
Short name:
HAP2
Alternative name(s):
Filament cap protein
Flagellar cap protein
Gene namesi
Name:fliD
Ordered Locus Names:HP_0752
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • bacterial-type flagellum Source: CACAO
  • bacterial-type flagellum hook Source: InterPro
  • extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Bacterial flagellum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 685684Flagellar hook-associated protein 2PRO_0000177019Add
BLAST

Interactioni

Subunit structurei

Homopentamer.By similarity

Protein-protein interaction databases

DIPiDIP-3401N.
IntActiP96786. 1 interaction.
MINTiMINT-176105.
STRINGi85962.HP0752.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili618 – 64730Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the FliD family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG1345.
KOiK02407.
OMAiFAAYDSQ.
OrthoDBiEOG6GN6X6.

Family and domain databases

InterProiIPR010809. FliD_C.
IPR003481. FliD_N.
[Graphical view]
PfamiPF07195. FliD_C. 1 hit.
PF02465. FliD_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P96786-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIGSLSSLG LGSKVLNYDV IDKLKDADEK ALIAPLDKKM EQNVEKQKAL
60 70 80 90 100
VEIKTLLSAL KGPVKTLSDY STYISRKSNV TGDALSASVG VGVPIQDIKV
110 120 130 140 150
DVQNLAQGDI NELGAKFSSR DDIFSQVDTT LKFYTQNKDY AVNIKAGMTL
160 170 180 190 200
GDVAQSITDA TNGEVMGIVM KTGGNDPYQL MVNTKNTGED NRVYFGSHLQ
210 220 230 240 250
STLTNKNALS LGVDGSGKSE VSLNLKGADG NMHEVPIMLE LPESASIKQK
260 270 280 290 300
NTAIQKAMEQ ALENDPNFKN LIANGDISID TLHGGESLII NDRRGGNIEV
310 320 330 340 350
KGSKAKELGF LQTTTQESDL LKSSRTIKEG KLEGVVSLNG QKLDLSALTK
360 370 380 390 400
ESNTSEENTD AIIQAINAKE GLSAFKNAEG KLVINSKTGM LTIKGEDALG
410 420 430 440 450
KASLKDLGLN AGMVQSYEAS QNTLFMSKNL QKASDSAFTY NGVSITRPTN
460 470 480 490 500
EVNDVISGVN ITLEQTTEPN KPAIISVSRD NQAIIDSLTE FVKAYNELIP
510 520 530 540 550
KLDEDTRYDA DTKIAGIFNG VGDIRAIRSS LNNVFSYSVH TDNGVESLMK
560 570 580 590 600
YGLSLDDKGV MSLDEAKLSS ALNSNPKATQ DFFYGSDSKD MGGREIHQEG
610 620 630 640 650
IFSKFNQVIA NLIDGGNAKL KIYEDSLDRD AKSLTKDKEN AQELLKTRYN
660 670 680
IMAERFAAYD SQISKANQKF NSVQMMIDQA AAKKN
Length:685
Mass (Da):74,131
Last modified:January 23, 2007 - v4
Checksum:i12D4F56473D047F6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti654 – 68532ERFAA…AAKKN → DVLPLMIAKSLKPIKNSIPC K in AAD07800 (PubMed:9252185).CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591A → S in strain: KCTC 0217BP.
Natural varianti86 – 861S → N in strain: KCTC 0217BP.
Natural varianti91 – 911V → A in strain: KCTC 0217BP.
Natural varianti193 – 1931V → I in strain: KCTC 0217BP.
Natural varianti231 – 2311N → S in strain: KCTC 0217BP.
Natural varianti258 – 2581M → I in strain: KCTC 0217BP.
Natural varianti270 – 2701N → D in strain: KCTC 0217BP.
Natural varianti363 – 3631I → V in strain: KCTC 0217BP.
Natural varianti368 – 3681A → S in strain: KCTC 0217BP.
Natural varianti373 – 3731S → N in strain: KCTC 0217BP.
Natural varianti422 – 4221N → G in strain: KCTC 0217BP.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82981 Genomic DNA. Translation: AAC35999.1.
AE000511 Genomic DNA. Translation: AAD07800.1.
PIRiH64613.
RefSeqiNP_207545.1. NC_000915.1.
YP_006934668.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07800; AAD07800; HP_0752.
GeneIDi900004.
KEGGiheo:C694_03870.
hpy:HP0752.
PATRICi20592793. VBIHelPyl33062_0785.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82981 Genomic DNA. Translation: AAC35999.1.
AE000511 Genomic DNA. Translation: AAD07800.1.
PIRiH64613.
RefSeqiNP_207545.1. NC_000915.1.
YP_006934668.1. NC_018939.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3401N.
IntActiP96786. 1 interaction.
MINTiMINT-176105.
STRINGi85962.HP0752.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07800; AAD07800; HP_0752.
GeneIDi900004.
KEGGiheo:C694_03870.
hpy:HP0752.
PATRICi20592793. VBIHelPyl33062_0785.

Phylogenomic databases

eggNOGiCOG1345.
KOiK02407.
OMAiFAAYDSQ.
OrthoDBiEOG6GN6X6.

Family and domain databases

InterProiIPR010809. FliD_C.
IPR003481. FliD_N.
[Graphical view]
PfamiPF07195. FliD_C. 1 hit.
PF02465. FliD_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of the Helicobacter pylori fliD gene, an essential factor in flagellar structure and motility."
    Kim J.S., Chang J.H., Chung S.I., Yum J.S.
    J. Bacteriol. 181:6969-6976(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-16, CHARACTERIZATION.
    Strain: KCTC 0217BP.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiFLID_HELPY
AccessioniPrimary (citable) accession number: P96786
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: April 29, 2015
This is version 89 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.