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P96786

- FLID_HELPY

UniProt

P96786 - FLID_HELPY

Protein

Flagellar hook-associated protein 2

Gene

fliD

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. Essential to colonize and establish infection in gastric mucosa as a result of its essential role in motility. Has effect on flaA gene transcription.

    GO - Biological processi

    1. bacterial-type flagellum-dependent swarming motility Source: CACAO
    2. cell adhesion Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Flagellar hook-associated protein 2
    Short name:
    HAP2
    Alternative name(s):
    Filament cap protein
    Flagellar cap protein
    Gene namesi
    Name:fliD
    Ordered Locus Names:HP_0752
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. bacterial-type flagellum Source: CACAO
    2. bacterial-type flagellum hook Source: InterPro
    3. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Bacterial flagellum, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 685684Flagellar hook-associated protein 2PRO_0000177019Add
    BLAST

    Interactioni

    Subunit structurei

    Homopentamer.By similarity

    Protein-protein interaction databases

    DIPiDIP-3401N.
    IntActiP96786. 1 interaction.
    MINTiMINT-176105.
    STRINGi85962.HP0752.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili618 – 64730Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FliD family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG1345.
    KOiK02407.
    OMAiTRPTNEV.
    OrthoDBiEOG6GN6X6.

    Family and domain databases

    InterProiIPR010809. FliD_C.
    IPR003481. FliD_N.
    [Graphical view]
    PfamiPF07195. FliD_C. 1 hit.
    PF02465. FliD_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P96786-1 [UniParc]FASTAAdd to Basket

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    MAIGSLSSLG LGSKVLNYDV IDKLKDADEK ALIAPLDKKM EQNVEKQKAL    50
    VEIKTLLSAL KGPVKTLSDY STYISRKSNV TGDALSASVG VGVPIQDIKV 100
    DVQNLAQGDI NELGAKFSSR DDIFSQVDTT LKFYTQNKDY AVNIKAGMTL 150
    GDVAQSITDA TNGEVMGIVM KTGGNDPYQL MVNTKNTGED NRVYFGSHLQ 200
    STLTNKNALS LGVDGSGKSE VSLNLKGADG NMHEVPIMLE LPESASIKQK 250
    NTAIQKAMEQ ALENDPNFKN LIANGDISID TLHGGESLII NDRRGGNIEV 300
    KGSKAKELGF LQTTTQESDL LKSSRTIKEG KLEGVVSLNG QKLDLSALTK 350
    ESNTSEENTD AIIQAINAKE GLSAFKNAEG KLVINSKTGM LTIKGEDALG 400
    KASLKDLGLN AGMVQSYEAS QNTLFMSKNL QKASDSAFTY NGVSITRPTN 450
    EVNDVISGVN ITLEQTTEPN KPAIISVSRD NQAIIDSLTE FVKAYNELIP 500
    KLDEDTRYDA DTKIAGIFNG VGDIRAIRSS LNNVFSYSVH TDNGVESLMK 550
    YGLSLDDKGV MSLDEAKLSS ALNSNPKATQ DFFYGSDSKD MGGREIHQEG 600
    IFSKFNQVIA NLIDGGNAKL KIYEDSLDRD AKSLTKDKEN AQELLKTRYN 650
    IMAERFAAYD SQISKANQKF NSVQMMIDQA AAKKN 685
    Length:685
    Mass (Da):74,131
    Last modified:January 23, 2007 - v4
    Checksum:i12D4F56473D047F6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti654 – 68532ERFAA…AAKKN → DVLPLMIAKSLKPIKNSIPC K in AAD07800. (PubMed:9252185)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti59 – 591A → S in strain: KCTC 0217BP.
    Natural varianti86 – 861S → N in strain: KCTC 0217BP.
    Natural varianti91 – 911V → A in strain: KCTC 0217BP.
    Natural varianti193 – 1931V → I in strain: KCTC 0217BP.
    Natural varianti231 – 2311N → S in strain: KCTC 0217BP.
    Natural varianti258 – 2581M → I in strain: KCTC 0217BP.
    Natural varianti270 – 2701N → D in strain: KCTC 0217BP.
    Natural varianti363 – 3631I → V in strain: KCTC 0217BP.
    Natural varianti368 – 3681A → S in strain: KCTC 0217BP.
    Natural varianti373 – 3731S → N in strain: KCTC 0217BP.
    Natural varianti422 – 4221N → G in strain: KCTC 0217BP.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82981 Genomic DNA. Translation: AAC35999.1.
    AE000511 Genomic DNA. Translation: AAD07800.1.
    PIRiH64613.
    RefSeqiNP_207545.1. NC_000915.1.
    YP_006934668.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07800; AAD07800; HP_0752.
    GeneIDi13869937.
    900004.
    KEGGiheo:C694_03870.
    hpy:HP0752.
    PATRICi20592793. VBIHelPyl33062_0785.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82981 Genomic DNA. Translation: AAC35999.1 .
    AE000511 Genomic DNA. Translation: AAD07800.1 .
    PIRi H64613.
    RefSeqi NP_207545.1. NC_000915.1.
    YP_006934668.1. NC_018939.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3401N.
    IntActi P96786. 1 interaction.
    MINTi MINT-176105.
    STRINGi 85962.HP0752.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07800 ; AAD07800 ; HP_0752 .
    GeneIDi 13869937.
    900004.
    KEGGi heo:C694_03870.
    hpy:HP0752.
    PATRICi 20592793. VBIHelPyl33062_0785.

    Phylogenomic databases

    eggNOGi COG1345.
    KOi K02407.
    OMAi TRPTNEV.
    OrthoDBi EOG6GN6X6.

    Family and domain databases

    InterProi IPR010809. FliD_C.
    IPR003481. FliD_N.
    [Graphical view ]
    Pfami PF07195. FliD_C. 1 hit.
    PF02465. FliD_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of the Helicobacter pylori fliD gene, an essential factor in flagellar structure and motility."
      Kim J.S., Chang J.H., Chung S.I., Yum J.S.
      J. Bacteriol. 181:6969-6976(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-16, CHARACTERIZATION.
      Strain: KCTC 0217BP.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiFLID_HELPY
    AccessioniPrimary (citable) accession number: P96786
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 86 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3