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Protein

UDP-glucose 6-dehydrogenase YwqF

Gene

ywqF

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of UDP-glucose into UDP-glucuronate, one of the precursors of teichuronic acid.1 Publication

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Enzyme regulationi

Competitively inhibited by UDP-glucose. Activated by phosphorylation, which may increase affinity for NAD+; inhibited by dephosphorylation.1 Publication

Pathwayi: UDP-alpha-D-glucuronate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose.
Proteins known to be involved in this subpathway in this organism are:
  1. UDP-glucose 6-dehydrogenase YwqF (ywqF), Putative UDP-glucose 6-dehydrogenase YtcA (ytcA), UDP-glucose 6-dehydrogenase TuaD (tuaD)
This subpathway is part of the pathway UDP-alpha-D-glucuronate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose, the pathway UDP-alpha-D-glucuronate biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei260By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi2 – 19NADSequence analysisAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCell wall biogenesis/degradation
LigandNAD

Enzyme and pathway databases

BioCyciBSUB:BSU36230-MONOMER
UniPathwayiUPA00038; UER00491

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase YwqF (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase
Short name:
UDP-GlcDH
Short name:
UDPGDH
Gene namesi
Name:ywqF
Ordered Locus Names:BSU36230
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi10Y → F: 30-fold decrease in activity but no decrease in the overall phosphorylation level. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002533411 – 440UDP-glucose 6-dehydrogenase YwqFAdd BLAST440

Post-translational modificationi

Phosphorylated on tyrosine residue(s). Phosphorylated by YwqD and dephosphorylated by YwqE in vitro.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP96718
PRIDEiP96718

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100019586

Structurei

3D structure databases

ProteinModelPortaliP96718
SMRiP96718
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C6Y Bacteria
COG1004 LUCA
HOGENOMiHOG000153773
InParanoidiP96718
KOiK00012
OMAiTMDAWSS
PhylomeDBiP96718

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028357 UDPglc_DH_bac
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500134 UDPglc_DH_bac, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit

Sequencei

Sequence statusi: Complete.

P96718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNITVIGTGY VGLVTGVSLS EIGHHVTCID IDAHKIDEMR KGISPIFEPG
60 70 80 90 100
LEELMRKNTA DGRLNFETSY EKGLAQADII FIAVGTPQKS DGHANLEQIT
110 120 130 140 150
DAAKRIAKHV KRDTVVVTKS TVPVGTNDLI NGLITEHLAE PVSISVASNP
160 170 180 190 200
EFLREGSAIY DTFHGDRIVI GTADEKTANT LEELFRPFQI PIYQTDIRSA
210 220 230 240 250
EMIKYASNAF LATKISFINE ISNICEKVGA DIEAVAYGMG QDKRIGSQFL
260 270 280 290 300
KAGIGYGGSC FPKDTNALVQ IAGNVEHDFE LLKSVIKVNN NQQAMLVDKA
310 320 330 340 350
LNRLGGVTGK TIALLGLSFK PNTDDMREAP SIVIADRLAA LDARIRAYDP
360 370 380 390 400
IAVSHAKHVL PQAVEYKETI EEAVKGSDAV MILTDWADIK QFPLAAYQDL
410 420 430 440
METPLIFDGR NCYTLDEALA AGVEYYSVGR KAVVPSGAIQ
Length:440
Mass (Da):47,784
Last modified:May 1, 1997 - v1
Checksum:i1ADA9454EBE1F645
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z92952 Genomic DNA Translation: CAB07444.1
AL009126 Genomic DNA Translation: CAB15640.1
PIRiA70067
RefSeqiNP_391504.1, NC_000964.3
WP_003243223.1, NZ_JNCM01000034.1

Genome annotation databases

EnsemblBacteriaiCAB15640; CAB15640; BSU36230
GeneIDi936890
KEGGibsu:BSU36230
PATRICifig|224308.179.peg.3921

Similar proteinsi

Entry informationi

Entry nameiYWQF_BACSU
AccessioniPrimary (citable) accession number: P96718
Secondary accession number(s): Q795B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: May 1, 1997
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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