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Protein

Tyrosine-protein phosphatase YwqE

Gene

ywqE

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Dephosphorylates the phosphotyrosine-containing proteins YwqD, YwqF and Ssb.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Cofactori

Enzyme regulationi

Inhibited by vanadate and sodium pyrophosphate. Not inhibited by sodium fluoride.

pH dependencei

Optimally active at alkaline pHs. Activity increases with increasing pHs.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese

Enzyme and pathway databases

BioCyciBSUB:BSU36240-MONOMER.
SABIO-RKP96717.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase YwqE (EC:3.1.3.48)
Gene namesi
Name:ywqE
Ordered Locus Names:BSU36240
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi3D → A: Large decrease in activity. 1 Publication1
Mutagenesisi5H → A: Large decrease in activity. 1 Publication1
Mutagenesisi7H → A: Large decrease in activity. 1
Mutagenesisi42H → A: Large decrease in activity. 1 Publication1
Mutagenesisi136H → A: Large decrease in activity. 1 Publication1
Mutagenesisi194D → A: Large decrease in activity. 1 Publication1
Mutagenesisi196H → A: Large decrease in activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578931 – 254Tyrosine-protein phosphatase YwqEAdd BLAST254

Proteomic databases

PaxDbiP96717.

Interactioni

Protein-protein interaction databases

IntActiP96717. 8 interactors.
STRINGi224308.Bsubs1_010100019591.

Structurei

Secondary structure

1254
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Beta strandi12 – 15Combined sources4
Helixi19 – 31Combined sources13
Beta strandi36 – 38Combined sources3
Beta strandi42 – 45Combined sources4
Helixi52 – 68Combined sources17
Beta strandi74 – 76Combined sources3
Beta strandi80 – 82Combined sources3
Helixi87 – 92Combined sources6
Helixi99 – 101Combined sources3
Beta strandi102 – 108Combined sources7
Helixi118 – 127Combined sources10
Beta strandi131 – 135Combined sources5
Helixi137 – 139Combined sources3
Helixi141 – 145Combined sources5
Helixi148 – 155Combined sources8
Beta strandi159 – 163Combined sources5
Helixi164 – 168Combined sources5
Turni169 – 171Combined sources3
Helixi173 – 184Combined sources12
Beta strandi190 – 192Combined sources3
Beta strandi197 – 201Combined sources5
Helixi205 – 216Combined sources12
Helixi219 – 232Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QY6X-ray1.80A1-254[»]
3QY7X-ray1.62A1-254[»]
ProteinModelPortaliP96717.
SMRiP96717.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP96717.

Family & Domainsi

Sequence similaritiesi

Belongs to the CpsB/CapC family.Curated

Phylogenomic databases

eggNOGiENOG4108RB3. Bacteria.
COG4464. LUCA.
HOGENOMiHOG000007624.
InParanoidiP96717.
KOiK01104.
OMAiVHPERNS.
PhylomeDBiP96717.

Family and domain databases

InterProiIPR016667. Caps_polysacc_synth_CpsB/CapC.
IPR016195. Pol/histidinol_Pase-like.
[Graphical view]
PIRSFiPIRSF016557. Caps_synth_CpsB. 1 hit.
SUPFAMiSSF89550. SSF89550. 1 hit.

Sequencei

Sequence statusi: Complete.

P96717-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDIHCHILP AMDDGAGDSA DSIEMARAAV RQGIRTIIAT PHHNNGVYKN
60 70 80 90 100
EPAAVREAAD QLNKRLIKED IPLHVLPGQE IRIYGEVEQD LAKRQLLSLN
110 120 130 140 150
DTKYILIEFP FDHVPRYAEQ LFYDLQLKGY IPVIAHPERN REIRENPSLL
160 170 180 190 200
YHLVEKGAAS QITSGSLAGI FGKQLKAFSL RLVEANLIHF VASDAHNVKT
210 220 230 240 250
RNFHTQEALY VLEKEFGSEL PYMLTENAEL LLRNQTIFRQ PPQPVKRRKL

FGFF
Length:254
Mass (Da):28,958
Last modified:May 1, 1997 - v1
Checksum:iE2625AE51E0E9A94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z92952 Genomic DNA. Translation: CAB07456.1.
AL009126 Genomic DNA. Translation: CAB15641.1.
PIRiH70066.
RefSeqiNP_391505.1. NC_000964.3.
WP_003227815.1. NZ_JNCM01000034.1.

Genome annotation databases

EnsemblBacteriaiCAB15641; CAB15641; BSU36240.
GeneIDi936893.
KEGGibsu:BSU36240.
PATRICi18979268. VBIBacSub10457_3796.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z92952 Genomic DNA. Translation: CAB07456.1.
AL009126 Genomic DNA. Translation: CAB15641.1.
PIRiH70066.
RefSeqiNP_391505.1. NC_000964.3.
WP_003227815.1. NZ_JNCM01000034.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QY6X-ray1.80A1-254[»]
3QY7X-ray1.62A1-254[»]
ProteinModelPortaliP96717.
SMRiP96717.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP96717. 8 interactors.
STRINGi224308.Bsubs1_010100019591.

Proteomic databases

PaxDbiP96717.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB15641; CAB15641; BSU36240.
GeneIDi936893.
KEGGibsu:BSU36240.
PATRICi18979268. VBIBacSub10457_3796.

Phylogenomic databases

eggNOGiENOG4108RB3. Bacteria.
COG4464. LUCA.
HOGENOMiHOG000007624.
InParanoidiP96717.
KOiK01104.
OMAiVHPERNS.
PhylomeDBiP96717.

Enzyme and pathway databases

BioCyciBSUB:BSU36240-MONOMER.
SABIO-RKP96717.

Miscellaneous databases

EvolutionaryTraceiP96717.

Family and domain databases

InterProiIPR016667. Caps_polysacc_synth_CpsB/CapC.
IPR016195. Pol/histidinol_Pase-like.
[Graphical view]
PIRSFiPIRSF016557. Caps_synth_CpsB. 1 hit.
SUPFAMiSSF89550. SSF89550. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYWQE_BACSU
AccessioniPrimary (citable) accession number: P96717
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.