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Protein

Multidrug resistance protein 3

Gene

bmr3

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Confers resistance to puromycin, tosufloxacin and norfloxacin.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Transport

Enzyme and pathway databases

BioCyciBSUB:BSU03070-MONOMER.

Protein family/group databases

TCDBi2.A.1.3.50. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein 3
Alternative name(s):
Multidrug-efflux transporter 3
Gene namesi
Name:bmr3
Synonyms:mdr
Ordered Locus Names:BSU03070
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence analysisAdd
BLAST
Transmembranei48 – 6821HelicalSequence analysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence analysisAdd
BLAST
Transmembranei109 – 12921HelicalSequence analysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence analysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence analysisAdd
BLAST
Transmembranei200 – 22021HelicalSequence analysisAdd
BLAST
Transmembranei228 – 24821HelicalSequence analysisAdd
BLAST
Transmembranei272 – 29221HelicalSequence analysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence analysisAdd
BLAST
Transmembranei333 – 35321HelicalSequence analysisAdd
BLAST
Transmembranei358 – 37821HelicalSequence analysisAdd
BLAST
Transmembranei399 – 42123HelicalSequence analysisAdd
BLAST
Transmembranei475 – 49521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Multidrug resistance protein 3PRO_0000375916Add
BLAST

Expressioni

Inductioni

Expression is dependent on the growth phase and decreases in the late log phase.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP96712.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000239126.
InParanoidiP96712.
OMAiAYACIAD.
PhylomeDBiP96712.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004638. Drug-R_transpt_efflux_EmrB.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00711. efflux_EmrB. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P96712-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTTTAKQAS TKFVVLGLLL GILMSAMDNT IVATAMGNIV ADLGSFDKFA
60 70 80 90 100
WVTASYMVAV MAGMPIYGKL SDMYGRKRFF LFGLIFFLIG SALCGIAQTM
110 120 130 140 150
NQLIIFRAIQ GIGGGALLPI AFTIIFDLFP PEKRGKMSGM FGAVFGLSSV
160 170 180 190 200
LGPLLGAIIT DSISWHWVFY INVPIGALSL FFIIRYYKES LEHRKQKIDW
210 220 230 240 250
GGAITLVVSI VCLMFALELG GKTYDWNSIQ IIGLFIVFAV FFIAFFIVER
260 270 280 290 300
KAEEPIISFW MFKNRLFATA QILAFLYGGT FIILAVFIPI FVQAVYGSSA
310 320 330 340 350
TSAGFILTPM MIGSVIGSMI GGIFQTKASF RNLMLISVIA FFIGMLLLSN
360 370 380 390 400
MTPDTARVWL TVFMMISGFG VGFNFSLLPA ASMNDLEPRF RGTANSTNSF
410 420 430 440 450
LRSFGMTLGV TIFGTVQTNV FTNKLNDAFS GMKGSAGSGA AQNIGDPQEI
460 470 480 490 500
FQAGTRSQIP DAILNRIIDA MSSSITYVFL LALIPIVLAA VTILFMGKAR
510
VKTTAEMTKK AN
Length:512
Mass (Da):55,689
Last modified:May 1, 1997 - v1
Checksum:iD789A593F2ADB262
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50098 Genomic DNA. Translation: BAA08793.1.
AL009126 Genomic DNA. Translation: CAB12101.2.
RefSeqiNP_388189.2. NC_000964.3.
WP_003246377.1. NZ_JNCM01000030.1.

Genome annotation databases

EnsemblBacteriaiCAB12101; CAB12101; BSU03070.
GeneIDi938345.
KEGGibsu:BSU03070.
PATRICi18972173. VBIBacSub10457_0315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50098 Genomic DNA. Translation: BAA08793.1.
AL009126 Genomic DNA. Translation: CAB12101.2.
RefSeqiNP_388189.2. NC_000964.3.
WP_003246377.1. NZ_JNCM01000030.1.

3D structure databases

ProteinModelPortaliP96712.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi2.A.1.3.50. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12101; CAB12101; BSU03070.
GeneIDi938345.
KEGGibsu:BSU03070.
PATRICi18972173. VBIBacSub10457_0315.

Phylogenomic databases

HOGENOMiHOG000239126.
InParanoidiP96712.
OMAiAYACIAD.
PhylomeDBiP96712.

Enzyme and pathway databases

BioCyciBSUB:BSU03070-MONOMER.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004638. Drug-R_transpt_efflux_EmrB.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00711. efflux_EmrB. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBMR3_BACSU
AccessioniPrimary (citable) accession number: P96712
Secondary accession number(s): O31471
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.