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P96711

- ARAR_BACSU

UniProt

P96711 - ARAR_BACSU

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Protein
Arabinose metabolism transcriptional repressor
Gene
araR, araC, yvbS, BSU33970
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional repressor of the arabinose utilization genes. Also regulates its own expression. Binds to two sequences within the promoters of the araABDLMNPQ-abfA operon and the araE gene, and to one sequence in the araR promoter.

Enzyme regulationi

Binding to DNA is inhibited by L-arabinose.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi30 – 4920H-T-H motif Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBSUB:BSU33970-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arabinose metabolism transcriptional repressor
Gene namesi
Name:araR
Synonyms:araC, yvbS
Ordered Locus Names:BSU33970
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU33970. [Micado]

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Arabinose metabolism transcriptional repressor
PRO_0000050620Add
BLAST

Proteomic databases

PaxDbiP96711.

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU33970.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1714
Helixi30 – 378
Helixi41 – 5313
Beta strandi56 – 605
Turni61 – 633
Beta strandi64 – 674
Beta strandi81 – 877
Beta strandi89 – 913
Helixi94 – 10714
Beta strandi111 – 1166
Helixi121 – 13313
Beta strandi137 – 1415
Helixi153 – 1619
Beta strandi166 – 1716
Beta strandi180 – 1834
Helixi185 – 19814
Beta strandi203 – 21210
Helixi213 – 22816
Helixi235 – 2373
Beta strandi238 – 2414
Helixi243 – 2464
Helixi249 – 26012
Turni261 – 2633
Beta strandi267 – 2704
Helixi274 – 28613
Turni291 – 2944
Beta strandi296 – 2983
Helixi305 – 3084
Beta strandi309 – 3113
Beta strandi314 – 3174
Helixi321 – 33515
Beta strandi345 – 3473
Beta strandi350 – 3523

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TB6X-ray2.21A/B71-362[»]
4EGYX-ray2.30A/B1-68[»]
4EGZX-ray2.30A/B1-68[»]
4H0EX-ray1.97A/B1-68[»]
ProteinModelPortaliP96711.
SMRiP96711. Positions 2-360.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7070HTH gntR-type
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1609.
HOGENOMiHOG000235268.
OrthoDBiEOG64BQ72.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR028082. Peripla_BP_I.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00392. GntR. 1 hit.
[Graphical view]
PRINTSiPR00035. HTHGNTR.
SMARTiSM00345. HTH_GNTR. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS50949. HTH_GNTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P96711-1 [UniParc]FASTAAdd to Basket

« Hide

MLPKYAQVKE EISSWINQGK ILPDQKIPTE NELMQQFGVS RHTIRKAIGD    50
LVSQGLLYSV QGGGTFVASR SAKSALHSNK TIGVLTTYIS DYIFPSIIRG 100
IESYLSEQGY SMLLTSTNNN PDNERRGLEN LLSQHIDGLI VEPTKSALQT 150
PNIGYYLNLE KNGIPFAMIN ASYAELAAPS FTLDDVKGGM MAAEHLLSLG 200
HTHMMGIFKA DDTQGVKRMN GFIQAHRERE LFPSPDMIVT FTTEEKESKL 250
LEKVKATLEK NSKHMPTAIL CYNDEIALKV IDMLREMDLK VPEDMSIVGY 300
DDSHFAQISE VKLTSVKHPK SVLGKAAAKY VIDCLEHKKP KQEDVIFEPE 350
LIIRQSARKL NE 362
Length:362
Mass (Da):40,488
Last modified:April 3, 2002 - v3
Checksum:i679DC8FEE69FB421
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X98354 Genomic DNA. Translation: CAA66999.1.
AL009126 Genomic DNA. Translation: CAB15402.2.
PIRiD69588.

Genome annotation databases

EnsemblBacteriaiCAB15402; CAB15402; BSU33970.
PATRICi18978794. VBIBacSub10457_3560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X98354 Genomic DNA. Translation: CAA66999.1 .
AL009126 Genomic DNA. Translation: CAB15402.2 .
PIRi D69588.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3TB6 X-ray 2.21 A/B 71-362 [» ]
4EGY X-ray 2.30 A/B 1-68 [» ]
4EGZ X-ray 2.30 A/B 1-68 [» ]
4H0E X-ray 1.97 A/B 1-68 [» ]
ProteinModelPortali P96711.
SMRi P96711. Positions 2-360.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU33970.

Proteomic databases

PaxDbi P96711.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB15402 ; CAB15402 ; BSU33970 .
PATRICi 18978794. VBIBacSub10457_3560.

Organism-specific databases

GenoListi BSU33970. [Micado ]

Phylogenomic databases

eggNOGi COG1609.
HOGENOMi HOG000235268.
OrthoDBi EOG64BQ72.

Enzyme and pathway databases

BioCyci BSUB:BSU33970-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR028082. Peripla_BP_I.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00392. GntR. 1 hit.
[Graphical view ]
PRINTSi PR00035. HTHGNTR.
SMARTi SM00345. HTH_GNTR. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS50949. HTH_GNTR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Negative regulation of L-arabinose metabolism in Bacillus subtilis: characterization of the araR (araC) gene."
    Sa-Nogueira I.M.G., Mota L.J.
    J. Bacteriol. 179:1598-1608(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "Mode of action of AraR, the key regulator of L-arabinose metabolism in Bacillus subtilis."
    Mota L.J., Tavares P., Sa-Nogueira I.M.G.
    Mol. Microbiol. 33:476-489(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-10, CHARACTERIZATION.
  4. "Control of the arabinose regulon in Bacillus subtilis by AraR in vivo: crucial roles of operators, cooperativity, and DNA looping."
    Mota L.J., Sarmento L.M., Sa-Nogueira I.M.G.
    J. Bacteriol. 183:4190-4201(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Strain: 168.

Entry informationi

Entry nameiARAR_BACSU
AccessioniPrimary (citable) accession number: P96711
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: April 3, 2002
Last modified: May 14, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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