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P96711 (ARAR_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arabinose metabolism transcriptional repressor
Gene names
Name:araR
Synonyms:araC, yvbS
Ordered Locus Names:BSU33970
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional repressor of the arabinose utilization genes. Also regulates its own expression. Binds to two sequences within the promoters of the araABDLMNPQ-abfA operon and the araE gene, and to one sequence in the araR promoter.

Enzyme regulation

Binding to DNA is inhibited by L-arabinose.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Contains 1 HTH gntR-type DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentCytoplasm
   LigandDNA-binding
   Molecular functionRepressor
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362Arabinose metabolism transcriptional repressor
PRO_0000050620

Regions

Domain1 – 7070HTH gntR-type
DNA binding30 – 4920H-T-H motif Potential

Secondary structure

............................................................. 362
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P96711 [UniParc].

Last modified April 3, 2002. Version 3.
Checksum: 679DC8FEE69FB421

FASTA36240,488
        10         20         30         40         50         60 
MLPKYAQVKE EISSWINQGK ILPDQKIPTE NELMQQFGVS RHTIRKAIGD LVSQGLLYSV 

        70         80         90        100        110        120 
QGGGTFVASR SAKSALHSNK TIGVLTTYIS DYIFPSIIRG IESYLSEQGY SMLLTSTNNN 

       130        140        150        160        170        180 
PDNERRGLEN LLSQHIDGLI VEPTKSALQT PNIGYYLNLE KNGIPFAMIN ASYAELAAPS 

       190        200        210        220        230        240 
FTLDDVKGGM MAAEHLLSLG HTHMMGIFKA DDTQGVKRMN GFIQAHRERE LFPSPDMIVT 

       250        260        270        280        290        300 
FTTEEKESKL LEKVKATLEK NSKHMPTAIL CYNDEIALKV IDMLREMDLK VPEDMSIVGY 

       310        320        330        340        350        360 
DDSHFAQISE VKLTSVKHPK SVLGKAAAKY VIDCLEHKKP KQEDVIFEPE LIIRQSARKL 


NE 

« Hide

References

« Hide 'large scale' references
[1]"Negative regulation of L-arabinose metabolism in Bacillus subtilis: characterization of the araR (araC) gene."
Sa-Nogueira I.M.G., Mota L.J.
J. Bacteriol. 179:1598-1608(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[3]"Mode of action of AraR, the key regulator of L-arabinose metabolism in Bacillus subtilis."
Mota L.J., Tavares P., Sa-Nogueira I.M.G.
Mol. Microbiol. 33:476-489(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-10, CHARACTERIZATION.
[4]"Control of the arabinose regulon in Bacillus subtilis by AraR in vivo: crucial roles of operators, cooperativity, and DNA looping."
Mota L.J., Sarmento L.M., Sa-Nogueira I.M.G.
J. Bacteriol. 183:4190-4201(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
Strain: 168.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X98354 Genomic DNA. Translation: CAA66999.1.
AL009126 Genomic DNA. Translation: CAB15402.2.
PIRD69588.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3TB6X-ray2.21A/B71-362[»]
4EGYX-ray2.30A/B1-68[»]
4EGZX-ray2.30A/B1-68[»]
4H0EX-ray1.97A/B1-68[»]
ProteinModelPortalP96711.
SMRP96711. Positions 2-360.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224308.BSU33970.

Proteomic databases

PaxDbP96711.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB15402; CAB15402; BSU33970.
PATRIC18978794. VBIBacSub10457_3560.

Organism-specific databases

GenoListBSU33970. [Micado]

Phylogenomic databases

eggNOGCOG1609.
HOGENOMHOG000235268.
OrthoDBEOG64BQ72.

Enzyme and pathway databases

BioCycBSUB:BSU33970-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR028082. Peripla_BP_I.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00392. GntR. 1 hit.
[Graphical view]
PRINTSPR00035. HTHGNTR.
SMARTSM00345. HTH_GNTR. 1 hit.
[Graphical view]
SUPFAMSSF53822. SSF53822. 1 hit.
PROSITEPS50949. HTH_GNTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARAR_BACSU
AccessionPrimary (citable) accession number: P96711
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: April 3, 2002
Last modified: May 14, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList