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Protein

Arabinose metabolism transcriptional repressor

Gene

araR

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor of the arabinose utilization genes. Also regulates its own expression. Binds to two sequences within the promoters of the araABDLMNPQ-abfA operon and the araE gene, and to one sequence in the araR promoter.

Enzyme regulationi

Binding to DNA is inhibited by L-arabinose.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi30 – 49H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBSUB:BSU33970-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arabinose metabolism transcriptional repressor
Gene namesi
Name:araR
Synonyms:araC, yvbS
Ordered Locus Names:BSU33970
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000506201 – 362Arabinose metabolism transcriptional repressorAdd BLAST362

Proteomic databases

PaxDbiP96711.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100018426.

Structurei

Secondary structure

1362
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 15Combined sources12
Turni16 – 19Combined sources4
Helixi30 – 37Combined sources8
Helixi41 – 53Combined sources13
Beta strandi56 – 60Combined sources5
Turni61 – 63Combined sources3
Beta strandi64 – 67Combined sources4
Beta strandi81 – 87Combined sources7
Beta strandi89 – 91Combined sources3
Helixi94 – 107Combined sources14
Beta strandi111 – 116Combined sources6
Helixi121 – 133Combined sources13
Beta strandi137 – 141Combined sources5
Helixi153 – 161Combined sources9
Beta strandi166 – 171Combined sources6
Beta strandi180 – 183Combined sources4
Helixi185 – 198Combined sources14
Beta strandi203 – 212Combined sources10
Helixi213 – 228Combined sources16
Helixi235 – 237Combined sources3
Beta strandi238 – 241Combined sources4
Helixi243 – 246Combined sources4
Helixi249 – 260Combined sources12
Turni261 – 263Combined sources3
Beta strandi267 – 270Combined sources4
Helixi274 – 286Combined sources13
Turni291 – 294Combined sources4
Beta strandi296 – 298Combined sources3
Helixi305 – 308Combined sources4
Beta strandi309 – 311Combined sources3
Beta strandi314 – 317Combined sources4
Helixi321 – 335Combined sources15
Beta strandi345 – 347Combined sources3
Beta strandi350 – 352Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TB6X-ray2.21A/B71-362[»]
4EGYX-ray2.30A/B1-68[»]
4EGZX-ray2.30A/B1-68[»]
4H0EX-ray1.97A/B1-68[»]
5D4RX-ray2.07A/B1-68[»]
5D4SX-ray1.97A/B1-68[»]
ProteinModelPortaliP96711.
SMRiP96711.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 70HTH gntR-typePROSITE-ProRule annotationAdd BLAST70

Sequence similaritiesi

Contains 1 HTH gntR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105CMD. Bacteria.
COG1609. LUCA.
HOGENOMiHOG000235268.
InParanoidiP96711.
OMAiKLTTIRH.

Family and domain databases

CDDicd07377. WHTH_GntR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR033532. AraR.
IPR028082. Peripla_BP_I.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR30146:SF39. PTHR30146:SF39. 1 hit.
PfamiPF00392. GntR. 1 hit.
[Graphical view]
PRINTSiPR00035. HTHGNTR.
SMARTiSM00345. HTH_GNTR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEiPS50949. HTH_GNTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P96711-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPKYAQVKE EISSWINQGK ILPDQKIPTE NELMQQFGVS RHTIRKAIGD
60 70 80 90 100
LVSQGLLYSV QGGGTFVASR SAKSALHSNK TIGVLTTYIS DYIFPSIIRG
110 120 130 140 150
IESYLSEQGY SMLLTSTNNN PDNERRGLEN LLSQHIDGLI VEPTKSALQT
160 170 180 190 200
PNIGYYLNLE KNGIPFAMIN ASYAELAAPS FTLDDVKGGM MAAEHLLSLG
210 220 230 240 250
HTHMMGIFKA DDTQGVKRMN GFIQAHRERE LFPSPDMIVT FTTEEKESKL
260 270 280 290 300
LEKVKATLEK NSKHMPTAIL CYNDEIALKV IDMLREMDLK VPEDMSIVGY
310 320 330 340 350
DDSHFAQISE VKLTSVKHPK SVLGKAAAKY VIDCLEHKKP KQEDVIFEPE
360
LIIRQSARKL NE
Length:362
Mass (Da):40,488
Last modified:April 3, 2002 - v3
Checksum:i679DC8FEE69FB421
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98354 Genomic DNA. Translation: CAA66999.1.
AL009126 Genomic DNA. Translation: CAB15402.2.
PIRiD69588.
RefSeqiWP_003243070.1. NZ_JNCM01000033.1.

Genome annotation databases

EnsemblBacteriaiCAB15402; CAB15402; BSU33970.
PATRICi18978794. VBIBacSub10457_3560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98354 Genomic DNA. Translation: CAA66999.1.
AL009126 Genomic DNA. Translation: CAB15402.2.
PIRiD69588.
RefSeqiWP_003243070.1. NZ_JNCM01000033.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TB6X-ray2.21A/B71-362[»]
4EGYX-ray2.30A/B1-68[»]
4EGZX-ray2.30A/B1-68[»]
4H0EX-ray1.97A/B1-68[»]
5D4RX-ray2.07A/B1-68[»]
5D4SX-ray1.97A/B1-68[»]
ProteinModelPortaliP96711.
SMRiP96711.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100018426.

Proteomic databases

PaxDbiP96711.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB15402; CAB15402; BSU33970.
PATRICi18978794. VBIBacSub10457_3560.

Phylogenomic databases

eggNOGiENOG4105CMD. Bacteria.
COG1609. LUCA.
HOGENOMiHOG000235268.
InParanoidiP96711.
OMAiKLTTIRH.

Enzyme and pathway databases

BioCyciBSUB:BSU33970-MONOMER.

Family and domain databases

CDDicd07377. WHTH_GntR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR033532. AraR.
IPR028082. Peripla_BP_I.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR30146:SF39. PTHR30146:SF39. 1 hit.
PfamiPF00392. GntR. 1 hit.
[Graphical view]
PRINTSiPR00035. HTHGNTR.
SMARTiSM00345. HTH_GNTR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEiPS50949. HTH_GNTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARAR_BACSU
AccessioniPrimary (citable) accession number: P96711
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: April 3, 2002
Last modified: November 2, 2016
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.