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Protein

Arabinose-proton symporter

Gene

araE

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Uptake of arabinose across the boundary membrane with the concomitant transport of protons into the cell (symport system).1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Symport, Transport

Enzyme and pathway databases

BioCyciBSUB:BSU33960-MONOMER.

Protein family/group databases

TCDBi2.A.1.1.55. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Arabinose-proton symporter
Alternative name(s):
Arabinose transporter
Gene namesi
Name:araE
Synonyms:yvbR
Ordered Locus Names:BSU33960
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4323HelicalSequence analysisAdd
BLAST
Transmembranei63 – 8523HelicalSequence analysisAdd
BLAST
Transmembranei92 – 11120HelicalSequence analysisAdd
BLAST
Transmembranei116 – 13823HelicalSequence analysisAdd
BLAST
Transmembranei150 – 17223HelicalSequence analysisAdd
BLAST
Transmembranei185 – 20723HelicalSequence analysisAdd
BLAST
Transmembranei266 – 28823HelicalSequence analysisAdd
BLAST
Transmembranei303 – 32523HelicalSequence analysisAdd
BLAST
Transmembranei332 – 35423HelicalSequence analysisAdd
BLAST
Transmembranei364 – 38623HelicalSequence analysisAdd
BLAST
Transmembranei398 – 42023HelicalSequence analysisAdd
BLAST
Transmembranei424 – 44623HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464Arabinose-proton symporterPRO_0000050288Add
BLAST

Proteomic databases

PaxDbiP96710.

Expressioni

Inductioni

Transcription is repressed by the binding of AraR to the promoter. L-arabinose acts as an inducer by inhibiting the binding of AraR to the DNA, thus allowing expression of the gene.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100018421.

Structurei

3D structure databases

ProteinModelPortaliP96710.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477. LUCA.
HOGENOMiHOG000202868.
InParanoidiP96710.
KOiK02100.
OMAiAYGMIPS.
OrthoDBiEOG65J51S.
PhylomeDBiP96710.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P96710-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNTPTQLEP NVPVTRSHSM GFVILISCAA GLGGLLYGYD TAVISGAIGF
60 70 80 90 100
LKDLYSLSPF MEGLVISSIM IGGVVGVGIS GFLSDRFGRR KILMTAALLF
110 120 130 140 150
AISAIVSALS QDVSTLIIAR IIGGLGIGMG SSLSVTYITE AAPPAIRGSL
160 170 180 190 200
SSLYQLFTIL GISATYFINL AVQRSGTYEW GVHTGWRWML AYGMVPSVIF
210 220 230 240 250
FLVLLVVPES PRWLAKAGKT NEALKILTRI NGETVAKEEL KNIENSLKIE
260 270 280 290 300
QMGSLSQLFK PGLRKALVIG ILLALFNQVI GMNAITYYGP EIFKMMGFGQ
310 320 330 340 350
NAGFVTTCIV GVVEVIFTVI AVLLIDKVGR KKLMSIGSAF MAIFMILIGT
360 370 380 390 400
SFYFELTSGI MMIVLILGFV AAFCVSVGPI TWIMISEIFP NHLRARAAGI
410 420 430 440 450
ATIFLWGANW AIGQFVPMMI DSFGLAYTFW IFAVINILCF LFVVTICPET
460
KNKSLEEIEK LWIK
Length:464
Mass (Da):50,411
Last modified:June 1, 1998 - v2
Checksum:i13B417061CB61DA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB15401.1.
X98354 Genomic DNA. Translation: CAA66998.1.
Y12105 Genomic DNA. Translation: CAA72812.1.
PIRiF69587.
RefSeqiNP_391276.1. NC_000964.3.
WP_003243899.1. NZ_JNCM01000033.1.

Genome annotation databases

EnsemblBacteriaiCAB15401; CAB15401; BSU33960.
GeneIDi938567.
KEGGibsu:BSU33960.
PATRICi18978792. VBIBacSub10457_3559.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB15401.1.
X98354 Genomic DNA. Translation: CAA66998.1.
Y12105 Genomic DNA. Translation: CAA72812.1.
PIRiF69587.
RefSeqiNP_391276.1. NC_000964.3.
WP_003243899.1. NZ_JNCM01000033.1.

3D structure databases

ProteinModelPortaliP96710.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100018421.

Protein family/group databases

TCDBi2.A.1.1.55. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP96710.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB15401; CAB15401; BSU33960.
GeneIDi938567.
KEGGibsu:BSU33960.
PATRICi18978792. VBIBacSub10457_3559.

Phylogenomic databases

eggNOGiCOG0477. LUCA.
HOGENOMiHOG000202868.
InParanoidiP96710.
KOiK02100.
OMAiAYGMIPS.
OrthoDBiEOG65J51S.
PhylomeDBiP96710.

Enzyme and pathway databases

BioCyciBSUB:BSU33960-MONOMER.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  2. "Negative regulation of L-arabinose metabolism in Bacillus subtilis: characterization of the araR (araC) gene."
    Sa-Nogueira I.M.G., Mota L.J.
    J. Bacteriol. 179:1598-1608(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-223.
    Strain: 168.
  3. "Cloning, functional analysis, and transcriptional regulation of the Bacillus subtilis araE gene involved in L-arabinose utilization."
    Sa-Nogueira I., Ramos S.S.
    J. Bacteriol. 179:7705-7711(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 223-464, FUNCTION.
    Strain: 168.
  4. "Mode of action of AraR, the key regulator of L-arabinose metabolism in Bacillus subtilis."
    Mota L.J., Tavares P., Sa-Nogueira I.M.G.
    Mol. Microbiol. 33:476-489(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRANSCRIPTIONAL REGULATION.

Entry informationi

Entry nameiARAE_BACSU
AccessioniPrimary (citable) accession number: P96710
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 1998
Last modified: July 6, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.