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Protein

HTH-type transcriptional repressor AseR

Gene

aseR

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Metal-responsive transcriptional regulator that represses transcription of the aseR-ydfA operon by binding specifically to its promoter. Binding of arsenite or antimonite causes the repressor to dissociate from the DNA.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi33 – 331ArsenitePROSITE-ProRule annotation
Metal bindingi35 – 351ArsenitePROSITE-ProRule annotation
Metal bindingi39 – 391ArsenitePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi34 – 5724H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Metal-thiolate cluster

Enzyme and pathway databases

BioCyciBSUB:BSU05330-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor AseR
Gene namesi
Name:aseR
Synonyms:ydeT
Ordered Locus Names:BSU05330
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi33 – 331C → S: Binds DNA, but loss of arsenite-mediated regulation; when associated with S-35. 1 Publication
Mutagenesisi35 – 351C → S: Binds DNA, but loss of arsenite-mediated regulation; when associated with S-33. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 111111HTH-type transcriptional repressor AseRPRO_0000378471Add
BLAST

Proteomic databases

PaxDbiP96677.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100002998.

Structurei

3D structure databases

ProteinModelPortaliP96677.
SMRiP96677. Positions 8-94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 105105HTH arsR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH arsR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG41082YX. Bacteria.
COG0640. LUCA.
HOGENOMiHOG000144506.
InParanoidiP96677.
KOiK03892.
OMAiCQLVDMF.
PhylomeDBiP96677.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P96677-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIDVAAMTR CLKTLSDQTR LIMMRLFLEQ EYCVCQLVDM FEMSQPAISQ
60 70 80 90 100
HLRKLKNAGF VNEDRRGQWR YYSINGSCPE FDTLQLILHQ IDQEDELLNH
110
IKQKKTQACC Q
Length:111
Mass (Da):13,088
Last modified:May 1, 1997 - v1
Checksum:i3E2B4088061AB1A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001488 Genomic DNA. Translation: BAA19367.1.
AL009126 Genomic DNA. Translation: CAB12340.1.
PIRiF69779.
RefSeqiNP_388414.1. NC_000964.3.
WP_003243257.1. NZ_JNCM01000031.1.

Genome annotation databases

EnsemblBacteriaiCAB12340; CAB12340; BSU05330.
GeneIDi938089.
KEGGibsu:BSU05330.
PATRICi18972668. VBIBacSub10457_0555.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001488 Genomic DNA. Translation: BAA19367.1.
AL009126 Genomic DNA. Translation: CAB12340.1.
PIRiF69779.
RefSeqiNP_388414.1. NC_000964.3.
WP_003243257.1. NZ_JNCM01000031.1.

3D structure databases

ProteinModelPortaliP96677.
SMRiP96677. Positions 8-94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100002998.

Proteomic databases

PaxDbiP96677.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12340; CAB12340; BSU05330.
GeneIDi938089.
KEGGibsu:BSU05330.
PATRICi18972668. VBIBacSub10457_0555.

Phylogenomic databases

eggNOGiENOG41082YX. Bacteria.
COG0640. LUCA.
HOGENOMiHOG000144506.
InParanoidiP96677.
KOiK03892.
OMAiCQLVDMF.
PhylomeDBiP96677.

Enzyme and pathway databases

BioCyciBSUB:BSU05330-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASER_BACSU
AccessioniPrimary (citable) accession number: P96677
Secondary accession number(s): Q797H3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Can also bind zinc in vitro, but it does not impair DNA binding.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.