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Protein

HTH-type transcriptional repressor AseR

Gene

aseR

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Metal-responsive transcriptional regulator that represses transcription of the aseR-ydfA operon by binding specifically to its promoter. Binding of arsenite or antimonite causes the repressor to dissociate from the DNA.1 Publication

Miscellaneous

Can also bind zinc in vitro, but it does not impair DNA binding.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi33ArsenitePROSITE-ProRule annotation1
Metal bindingi35ArsenitePROSITE-ProRule annotation1
Metal bindingi39ArsenitePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi34 – 57H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Metal-thiolate cluster

Enzyme and pathway databases

BioCyciBSUB:BSU05330-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor AseR
Gene namesi
Name:aseR
Synonyms:ydeT
Ordered Locus Names:BSU05330
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi33C → S: Binds DNA, but loss of arsenite-mediated regulation; when associated with S-35. 1 Publication1
Mutagenesisi35C → S: Binds DNA, but loss of arsenite-mediated regulation; when associated with S-33. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003784711 – 111HTH-type transcriptional repressor AseRAdd BLAST111

Proteomic databases

PaxDbiP96677.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100002998.

Structurei

3D structure databases

ProteinModelPortaliP96677.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 105HTH arsR-typePROSITE-ProRule annotationAdd BLAST105

Phylogenomic databases

eggNOGiENOG41082YX. Bacteria.
COG0640. LUCA.
HOGENOMiHOG000144506.
InParanoidiP96677.
KOiK03892.
OMAiCQLVDMF.
PhylomeDBiP96677.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF01022. HTH_5. 1 hit.
PRINTSiPR00778. HTHARSR.
SMARTiView protein in SMART
SM00418. HTH_ARSR. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS50987. HTH_ARSR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P96677-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIDVAAMTR CLKTLSDQTR LIMMRLFLEQ EYCVCQLVDM FEMSQPAISQ
60 70 80 90 100
HLRKLKNAGF VNEDRRGQWR YYSINGSCPE FDTLQLILHQ IDQEDELLNH
110
IKQKKTQACC Q
Length:111
Mass (Da):13,088
Last modified:May 1, 1997 - v1
Checksum:i3E2B4088061AB1A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001488 Genomic DNA. Translation: BAA19367.1.
AL009126 Genomic DNA. Translation: CAB12340.1.
PIRiF69779.
RefSeqiNP_388414.1. NC_000964.3.
WP_003243257.1. NZ_JNCM01000031.1.

Genome annotation databases

EnsemblBacteriaiCAB12340; CAB12340; BSU05330.
GeneIDi938089.
KEGGibsu:BSU05330.
PATRICi18972668. VBIBacSub10457_0555.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001488 Genomic DNA. Translation: BAA19367.1.
AL009126 Genomic DNA. Translation: CAB12340.1.
PIRiF69779.
RefSeqiNP_388414.1. NC_000964.3.
WP_003243257.1. NZ_JNCM01000031.1.

3D structure databases

ProteinModelPortaliP96677.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100002998.

Proteomic databases

PaxDbiP96677.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12340; CAB12340; BSU05330.
GeneIDi938089.
KEGGibsu:BSU05330.
PATRICi18972668. VBIBacSub10457_0555.

Phylogenomic databases

eggNOGiENOG41082YX. Bacteria.
COG0640. LUCA.
HOGENOMiHOG000144506.
InParanoidiP96677.
KOiK03892.
OMAiCQLVDMF.
PhylomeDBiP96677.

Enzyme and pathway databases

BioCyciBSUB:BSU05330-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF01022. HTH_5. 1 hit.
PRINTSiPR00778. HTHARSR.
SMARTiView protein in SMART
SM00418. HTH_ARSR. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS50987. HTH_ARSR_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiASER_BACSU
AccessioniPrimary (citable) accession number: P96677
Secondary accession number(s): Q797H3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: May 1, 1997
Last modified: February 15, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.