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Protein

Probable C4-dicarboxylate sensor kinase

Gene

dctS

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Member of the two-component regulatory system DctS/DctR. Probably activates DctR by phosphorylation (By similarity). Essential for expression of dctP.By similarity2 Publications

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
Biological processTwo-component regulatory system
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU04450-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable C4-dicarboxylate sensor kinase (EC:2.7.13.3)
Gene namesi
Name:dctS
Synonyms:ydbF
Ordered Locus Names:BSU04450
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 172ExtracellularSequence analysisAdd BLAST140
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 535CytoplasmicSequence analysisAdd BLAST342

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000747281 – 535Probable C4-dicarboxylate sensor kinaseAdd BLAST535

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei336Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP96601
PRIDEiP96601

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100002518

Structurei

3D structure databases

ProteinModelPortaliP96601
SMRiP96601
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini213 – 276PASAdd BLAST64
Domaini333 – 528Histidine kinasePROSITE-ProRule annotationAdd BLAST196

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CEQ Bacteria
COG3290 LUCA
HOGENOMiHOG000241936
InParanoidiP96601
KOiK11691
OMAiNHEHMNK
PhylomeDBiP96601

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
cd00130 PAS, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR033463 sCache_3
IPR029151 Sensor-like_sf
IPR004358 Sig_transdc_His_kin-like_C
IPR016120 Sig_transdc_His_kin_SpoOB
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF17203 sCache_3_2, 1 hit
PRINTSiPR00344 BCTRLSENSOR
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF103190 SSF103190, 1 hit
SSF55785 SSF55785, 1 hit
SSF55874 SSF55874, 1 hit
SSF55890 SSF55890, 1 hit
PROSITEiView protein in PROSITE
PS50109 HIS_KIN, 1 hit

Sequencei

Sequence statusi: Complete.

P96601-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKKLSIRW KITILSYILV IFSFLIGGIV LIGNIQHTEE RELKKRLMNT
60 70 80 90 100
ARTVSEMTEV KEALARKKQT EAVRHAVEEI RMINEADYIV VMDMNHIRYT
110 120 130 140 150
HPVSTSIGKK SEGADEEAAF AEHIYFSEAK GEIGTAVRAF YPVKDQDLNQ
160 170 180 190 200
IGVVLVGKTL PGIADILLHL KRDIAFIVVL TLGFGLAGSF LLARHIKKQM
210 220 230 240 250
FQLEPHEIVR MYEERTATFH SMNEGVIAID NRLVITIFNE KAKQIFEVQG
260 270 280 290 300
DLIGKVIWEV LKDSRLPEIV ERNKAVYNEE IRVSGKVIMS SRIPIVMKKK
310 320 330 340 350
VIGAVAIFQD RTEAAKMAEE LTGVRNFVEA LRVQNHEHMN KLHTIAGLIQ
360 370 380 390 400
LGKSEKALQL AFQASTEQEN VTEFLHRSIQ NDAAAGLLLS KIRRGRELGI
410 420 430 440 450
AVHIDENSSL QQFPEHVDQH DIVVLLGNLI ENAFGSFETV QSEDKRIDIS
460 470 480 490 500
IEQTDDILAI LIEDNGCGIE PTHMPRLYDK GFTVNKTGGT GYGLYLVKQI
510 520 530
IDKGSGTIEV DSHAGQGTSF SIVFPMKGEE AQHGS
Length:535
Mass (Da):59,942
Last modified:May 1, 1997 - v1
Checksum:i614BDA8BE8F10CFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001488 Genomic DNA Translation: BAA19282.1
AL009126 Genomic DNA Translation: CAB12252.1
PIRiA69771
RefSeqiNP_388326.1, NC_000964.3
WP_003234348.1, NZ_JNCM01000031.1

Genome annotation databases

EnsemblBacteriaiCAB12252; CAB12252; BSU04450
GeneIDi938231
KEGGibsu:BSU04450
PATRICifig|224308.179.peg.471

Entry informationi

Entry nameiDCTS_BACSU
AccessioniPrimary (citable) accession number: P96601
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

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