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Protein

HTH-type transcriptional regulator LrpC

Gene

lrpC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator with a possible role in regulation of amino acid metabolism. Plays a role in the growth phase transition.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi22 – 41H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBSUB:BSU04250-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator LrpC
Gene namesi
Name:lrpC
Synonyms:ydaI
Ordered Locus Names:BSU04250
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001117401 – 144HTH-type transcriptional regulator LrpCAdd BLAST144

Proteomic databases

PaxDbiP96582.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100002413.

Structurei

Secondary structure

1144
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 16Combined sources12
Helixi22 – 29Combined sources8
Helixi33 – 45Combined sources13
Beta strandi48 – 56Combined sources9
Helixi59 – 61Combined sources3
Beta strandi65 – 73Combined sources9
Helixi74 – 76Combined sources3
Helixi78 – 86Combined sources9
Beta strandi91 – 111Combined sources21
Helixi112 – 122Combined sources11
Turni123 – 125Combined sources3
Beta strandi126 – 136Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CFXX-ray2.40A/B/C/D/E/F/G/H1-144[»]
ProteinModelPortaliP96582.
SMRiP96582.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP96582.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 64HTH asnC-typePROSITE-ProRule annotationAdd BLAST62

Sequence similaritiesi

Contains 1 HTH asnC-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1522. LUCA.
HOGENOMiHOG000115327.
InParanoidiP96582.
KOiK03719.
OMAiCAMEELD.
PhylomeDBiP96582.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.920. 1 hit.
InterProiIPR000485. AsnC-type_HTH_dom.
IPR011008. Dimeric_a/b-barrel.
IPR019888. Tscrpt_reg_AsnC-typ.
IPR019887. Tscrpt_reg_AsnC/Lrp_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01037. AsnC_trans_reg. 1 hit.
[Graphical view]
PRINTSiPR00033. HTHASNC.
SMARTiSM00344. HTH_ASNC. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54909. SSF54909. 1 hit.
PROSITEiPS50956. HTH_ASNC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P96582-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLDQIDLNI IEELKKDSRL SMRELGRKIK LSPPSVTERV RQLESFGIIK
60 70 80 90 100
QYTLEVDQKK LGLPVSCIVE ATVKNADYER FKSYIQTLPN IEFCYRIAGA
110 120 130 140
ACYMLKINAE SLEAVEDFIN KTSPYAQTVT HVIFSEIDTK NGRG
Length:144
Mass (Da):16,450
Last modified:May 30, 2000 - v2
Checksum:i78852BE30103417F
GO

Sequence cautioni

The sequence BAA19262 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001488 Genomic DNA. Translation: BAA19262.1. Different initiation.
AL009126 Genomic DNA. Translation: CAB12232.1.
PIRiF69653.
RefSeqiNP_388306.1. NC_000964.3.
WP_003246585.1. NZ_JNCM01000031.1.

Genome annotation databases

EnsemblBacteriaiCAB12232; CAB12232; BSU04250.
GeneIDi940147.
KEGGibsu:BSU04250.
PATRICi18972428. VBIBacSub10457_0442.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001488 Genomic DNA. Translation: BAA19262.1. Different initiation.
AL009126 Genomic DNA. Translation: CAB12232.1.
PIRiF69653.
RefSeqiNP_388306.1. NC_000964.3.
WP_003246585.1. NZ_JNCM01000031.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CFXX-ray2.40A/B/C/D/E/F/G/H1-144[»]
ProteinModelPortaliP96582.
SMRiP96582.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100002413.

Proteomic databases

PaxDbiP96582.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12232; CAB12232; BSU04250.
GeneIDi940147.
KEGGibsu:BSU04250.
PATRICi18972428. VBIBacSub10457_0442.

Phylogenomic databases

eggNOGiCOG1522. LUCA.
HOGENOMiHOG000115327.
InParanoidiP96582.
KOiK03719.
OMAiCAMEELD.
PhylomeDBiP96582.

Enzyme and pathway databases

BioCyciBSUB:BSU04250-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP96582.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.920. 1 hit.
InterProiIPR000485. AsnC-type_HTH_dom.
IPR011008. Dimeric_a/b-barrel.
IPR019888. Tscrpt_reg_AsnC-typ.
IPR019887. Tscrpt_reg_AsnC/Lrp_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01037. AsnC_trans_reg. 1 hit.
[Graphical view]
PRINTSiPR00033. HTHASNC.
SMARTiSM00344. HTH_ASNC. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54909. SSF54909. 1 hit.
PROSITEiPS50956. HTH_ASNC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRPC_BACSU
AccessioniPrimary (citable) accession number: P96582
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.