Reviewed, UniProtKB/Swiss-Prot P96556 (TRPE_ARTGO)

Names and origin

Protein names

Recommended name:
    Anthranilate synthase component 1
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I

Gene names

Name:

trpE

Organism

Arthrobacter globiformis

Taxonomic identifier

1665 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	531 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 531	531	Anthranilate synthase component 1		PRO_0000154075

Sequences

	Sequence		Length	Mass (Da)
	P96556-1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: AFA71DA7A8A6674C	FASTA	531	57,369
	10 20 30 40 50 60 MQDLGIISPG LEEFRELAAH SRVIPVRLKV LADAETPIGL YRKLAQGQPG TFLMESAAVG 70 80 90 100 110 120 GAWSRYSFIG SRSRATLTTK DGQAHWLGEP PAGVPVDGNP VDAIRDTIEA LRTDRFDGLP 130 140 150 160 170 180 PFTSGLVGFL GWETVRHWEK LTRPPEDDLQ LPELALNLVT DMAVHDNMDG TVLLIANAIN 190 200 210 220 230 240 FDNSSERVDE AWHDAVARVK ELLARISTPV LQPVSVLEPA ALDFAASVQE RWNEPEYLAA 250 260 270 280 290 300 LDRGKEAIVD GEVFQVVISR RFEMECGASP LDVYRVLRNT NPSPYMYIFS LEDAAGRQYS 310 320 330 340 350 360 IVGSSPEALV TVTGEDVITH PIAGSRPRGK TVDADKALAE ELLADQKERA EHLMLVDLSR 370 380 390 400 410 420 NDLSKVCVAG SVDVTQFMEV ERFSHIMHLV STVVGRLAPT AKAYDVLKAT FPAGTLSGAP 430 440 450 460 470 480 KPRALRLLDE LEPHRRGIYG GVVGYLDFAG DMDMAIAIRS ALLREGRAYV QAGGGIVADS 490 500 510 520 530 SNPAEAQETV NKAAAPLRAV HTAGSLHNIT PDSVSAPDSV SSPDSVTEAN S

References

[1]	Chernova T., Viswanathan V.K., Austria N., Nichols B.P. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 8010 / IFO 12137 / DSM 20124 / NCIB 8907.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U89690 Genomic DNA. Translation: AAB49479.1.
3D structure databases
SMR	P96556. Positions 27-500.
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.1.3.27. 1012.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR005256. Anth_synthI. IPR019999. Anthranilate_synth_I_C. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHER	PTHR11236. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
TIGRFAMs	TIGR00564. trpE_most. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_ARTGO

Accession

Primary (citable) accession number: P96556

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 1, 1997
Last modified:	February 9, 2010
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)