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P96465 (BLA2_STEMA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase L2

EC=3.5.2.6
Alternative name(s):
Penicillinase
OrganismStenotrophomonas maltophilia (Pseudomonas maltophilia) (Xanthomonas maltophilia)
Taxonomic identifier40324 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Post-translational modification

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological_processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3535Tat-type signal Potential
Chain36 – 303268Beta-lactamase L2
PRO_0000017021

Regions

Region247 – 2493Substrate binding By similarity

Sites

Active site831Acyl-ester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P96465 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: C278DAF4C824FD3C

FASTA30332,208
        10         20         30         40         50         60 
MLARRRFLQF SGAAVASSLA LPLLARAAGK TAASAPTDAA LTAATDFAAL EKAVRGRFGV 

        70         80         90        100        110        120 
TLLDTASGRR IGHRQDERFP MCSTFKSVLA ATVLSQAERQ PALLDTRVPV RDADLLSHAP 

       130        140        150        160        170        180 
VTRRHAGKDM TVRDLCRATI ITSDNTAANL LFGVVGGPPA VTAFLRSIGD AVSRTDRLEP 

       190        200        210        220        230        240 
ELNSFAKGDP RDTTTPAAMA ATLQRVVLGE VLQLASRQQL ADWLIDNETG DACLRAGLGK 

       250        260        270        280        290        300 
LWRVRDKTGS NGEDARNDIA VLWPVAGGAP WVLTAYLQAG AISYEQRATV LAQVGRIADR 


LIG 

« Hide

References

[1]"Sequence analysis and enzyme kinetics of the L2 serine beta-lactamase from Stenotrophomonas maltophilia."
Walsh T.R., Macgowan A.P., Bennett P.M.
Antimicrob. Agents Chemother. 41:1460-1464(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: IID 1275.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y08562 Genomic DNA. Translation: CAA69869.1.

3D structure databases

ProteinModelPortalP96465.
SMRP96465. Positions 33-303.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
IPR006311. TAT_signal.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLA2_STEMA
AccessionPrimary (citable) accession number: P96465
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: October 16, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families