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P96465

- BLA2_STEMA

UniProt

P96465 - BLA2_STEMA

Protein

Beta-lactamase L2

Gene
N/A
Organism
Stenotrophomonas maltophilia (Pseudomonas maltophilia) (Xanthomonas maltophilia)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    • Comment

    Functioni

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei83 – 831Acyl-ester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. beta-lactam antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase L2 (EC:3.5.2.6)
    Alternative name(s):
    Penicillinase
    OrganismiStenotrophomonas maltophilia (Pseudomonas maltophilia) (Xanthomonas maltophilia)
    Taxonomic identifieri40324 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Tat-type signalPROSITE-ProRule annotationAdd
    BLAST
    Chaini36 – 303268Beta-lactamase L2PRO_0000017021Add
    BLAST

    Post-translational modificationi

    Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

    Structurei

    3D structure databases

    ProteinModelPortaliP96465.
    SMRiP96465. Positions 33-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni247 – 2493Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-A beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    IPR023650. Beta-lactam_class-A_AS.
    IPR006311. TAT_signal.
    [Graphical view]
    PRINTSiPR00118. BLACTAMASEA.
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
    PS51318. TAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P96465-1 [UniParc]FASTAAdd to Basket

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    MLARRRFLQF SGAAVASSLA LPLLARAAGK TAASAPTDAA LTAATDFAAL    50
    EKAVRGRFGV TLLDTASGRR IGHRQDERFP MCSTFKSVLA ATVLSQAERQ 100
    PALLDTRVPV RDADLLSHAP VTRRHAGKDM TVRDLCRATI ITSDNTAANL 150
    LFGVVGGPPA VTAFLRSIGD AVSRTDRLEP ELNSFAKGDP RDTTTPAAMA 200
    ATLQRVVLGE VLQLASRQQL ADWLIDNETG DACLRAGLGK LWRVRDKTGS 250
    NGEDARNDIA VLWPVAGGAP WVLTAYLQAG AISYEQRATV LAQVGRIADR 300
    LIG 303
    Length:303
    Mass (Da):32,208
    Last modified:May 1, 1997 - v1
    Checksum:iC278DAF4C824FD3C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08562 Genomic DNA. Translation: CAA69869.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08562 Genomic DNA. Translation: CAA69869.1 .

    3D structure databases

    ProteinModelPortali P96465.
    SMRi P96465. Positions 33-303.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    IPR023650. Beta-lactam_class-A_AS.
    IPR006311. TAT_signal.
    [Graphical view ]
    PRINTSi PR00118. BLACTAMASEA.
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
    PS51318. TAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis and enzyme kinetics of the L2 serine beta-lactamase from Stenotrophomonas maltophilia."
      Walsh T.R., Macgowan A.P., Bennett P.M.
      Antimicrob. Agents Chemother. 41:1460-1464(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: IID 1275.

    Entry informationi

    Entry nameiBLA2_STEMA
    AccessioniPrimary (citable) accession number: P96465
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3