Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Histidine kinase

Gene

trcS

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.SAAS annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calcium ion binding Source: MTBBASE
  • manganese ion binding Source: MTBBASE
  • phosphorelay sensor kinase activity Source: InterPro
  • protein kinase activity Source: MTBBASE

GO - Biological processi

  • protein autophosphorylation Source: MTBBASE
Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotationImported, Transferase

Keywords - Biological processi

Two-component regulatory systemSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-5192-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Histidine kinaseImported
Submitted name:
Two component sensor histidine kinase TrcSImported
Gene namesi
Name:trcSImported
Ordered Locus Names:Rv1032cImported
ORF Names:LH57_05645Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1032c.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 45HelicalSequence analysisAdd BLAST22
Transmembranei188 – 210HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiP96368.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1032c.

Structurei

3D structure databases

ProteinModelPortaliP96368.
SMRiP96368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 269HAMPInterPro annotationAdd BLAST63
Domaini284 – 502Histidine kinaseInterPro annotationAdd BLAST219

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG4105US7. Bacteria.
COG0642. LUCA.
HOGENOMiHOG000223177.
KOiK07656.
OMAiEHIFRPF.
PhylomeDBiP96368.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P96368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPDRNTRSR KAPCWRPRSL RQQLLLGVLA VVTVVLVAVG VVSVLSLSGY
60 70 80 90 100
VTAMNDAELV ESLHALNHSY TRYRDSAQTS TPTGNLPMSQ AVLEFTGQTP
110 120 130 140 150
GNLIAVLHDG VVIGSAVFSE DGARPAPPDV IRAIEAQVWD GGPPRVESLG
160 170 180 190 200
SLGAYQVDSS AAGADRLFVG VSLSLANQII ARKKVTTVAL VGAALVVTAA
210 220 230 240 250
LTVWVVGYAL RPLRRVAATA AEVATMPLTD DDHQISVRVR PGDTDPDNEV
260 270 280 290 300
GIVGHTLNRL LDNVDGALAH RVDSDLRMRQ FITDASHELR TPLAAIQGYA
310 320 330 340 350
ELTRQDSSDL PPTTEYALAR IESEARRMTL LVDELLLLSR LSEGEDLETE
360 370 380 390 400
DLDLTDLVIN AVNDAAVAAP THRWVKNLPD EPVWVNGDHA RLHQLVSNLL
410 420 430 440 450
TNAWVHTQPG VTVTIGITCH RTGPNAPCVE LSVTDDGPDI DPEILPHLFD
460 470 480 490 500
RFVRASKSRS NGSGHGLGLA IVSSIVKAHR GSVTAESGNG QTVFRVRLPM

IEQQIATTA
Length:509
Mass (Da):54,591
Last modified:May 1, 1997 - v1
Checksum:i8EA2F0B3DB565922
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR13771.1.
AL123456 Genomic DNA. Translation: CCP43783.1.
RefSeqiNP_215548.1. NC_000962.3.
WP_003405324.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR13771; AIR13771; LH57_05645.
CCP43783; CCP43783; Rv1032c.
GeneIDi887790.
KEGGimtu:Rv1032c.
mtv:RVBD_1032c.
PATRICi18124082. VBIMycTub22151_1162.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR13771.1.
AL123456 Genomic DNA. Translation: CCP43783.1.
RefSeqiNP_215548.1. NC_000962.3.
WP_003405324.1. NZ_KK339370.1.

3D structure databases

ProteinModelPortaliP96368.
SMRiP96368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1032c.

Proteomic databases

PRIDEiP96368.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR13771; AIR13771; LH57_05645.
CCP43783; CCP43783; Rv1032c.
GeneIDi887790.
KEGGimtu:Rv1032c.
mtv:RVBD_1032c.
PATRICi18124082. VBIMycTub22151_1162.

Organism-specific databases

TubercuListiRv1032c.

Phylogenomic databases

eggNOGiENOG4105US7. Bacteria.
COG0642. LUCA.
HOGENOMiHOG000223177.
KOiK07656.
OMAiEHIFRPF.
PhylomeDBiP96368.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-5192-MONOMER.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP96368_MYCTU
AccessioniPrimary (citable) accession number: P96368
Secondary accession number(s): F2GHA7
, I6XAE7, P96908, Q79B74, Q7D8Z0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.