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P96348 (BLA6_KLEPN) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase SHV-6

EC=3.5.2.6
Gene names
Name:bla
Synonyms:shv6
OrganismKlebsiella pneumoniae
Taxonomic identifier573 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Protein attributes

Sequence length260 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

SHV enzymes hydrolyze broad spectrum cephalosporins notably cefotaxime and ceftazidime.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
   PTMDisulfide bond
Gene Ontology (GO)
   Biological_processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide‹1 – 11›11 Potential
Chain12 – ›260›249Beta-lactamase SHV-6
PRO_0000016985

Regions

Region220 – 2223Substrate binding By similarity

Sites

Active site561Acyl-ester intermediate By similarity
Active site1541Proton acceptor By similarity

Amino acid modifications

Disulfide bond63 ↔ 109 By similarity

Experimental info

Non-terminal residue11
Non-terminal residue2601

Sequences

Sequence LengthMass (Da)Tools
P96348 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 26A8E2D43632EAA0

FASTA26028,157
        10         20         30         40         50         60 
LLATLPLAVH ASPQPLEQIK LSESQLSGRV GMIEMDLASG RTLTAWRADE RFPMMSTFKV 

        70         80         90        100        110        120 
VLCGAVLARV DAGDEQLERK IHYRQQDLVD YSPVSEKHLA DGMTVGELCA AAITMSDNSA 

       130        140        150        160        170        180 
ANLLLATVGG PAGLTAFLRQ IGDNVTRLDR WETELNEALP GDARATTTPA SMAATLRKLL 

       190        200        210        220        230        240 
TSQRLSARSQ RQLLQWMVDD RVAGPLIRSV LPAGWFIADK TGAGERGARG IVALLGPNNK 

       250        260 
AERIVVIYLR DTPASMAERN 

« Hide

References

[1]"Substitution of alanine for aspartate at position 179 in the SHV-6 extended-spectrum beta-lactamase."
Arlet G., Rouveau M., Philippon A.
FEMS Microbiol. Lett. 152:163-167(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: SLK-47.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y11069 Genomic DNA. Translation: CAA71948.1.

3D structure databases

ProteinModelPortalP96348.
SMRP96348. Positions 12-260.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLA6_KLEPN
AccessionPrimary (citable) accession number: P96348
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: October 16, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families