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P96318

- IDH_CALNO

UniProt

P96318 - IDH_CALNO

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Caldococcus noboribetus
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit.By similarity

Temperature dependencei

Optimum temperature is 98 degrees Celsius. Thermostable.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei108 – 1081NADPBy similarity
Binding sitei117 – 1171SubstrateBy similarity
Binding sitei119 – 1191SubstrateBy similarity
Binding sitei123 – 1231SubstrateBy similarity
Binding sitei133 – 1331SubstrateBy similarity
Binding sitei156 – 1561SubstrateBy similarity
Sitei163 – 1631Critical for catalysisBy similarity
Sitei230 – 2301Critical for catalysisBy similarity
Metal bindingi308 – 3081Magnesium or manganeseBy similarity
Binding sitei353 – 3531NADP; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei393 – 3931NADPBy similarity
Binding sitei397 – 3971NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi340 – 3467NADPBy similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
OrganismiCaldococcus noboribetus
Taxonomic identifieri57174 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesCaldococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429Isocitrate dehydrogenase [NADP]PRO_0000083573Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei117 – 1171PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP96318.
SMRiP96318. Positions 3-423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P96318-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSHPCTADE AKPPSEGQLA RFENGKLIVP DNLIVAYFKG DGIGPEIVES
60 70 80 90 100
AKKVLDAAVD KAYGGTRRIV WWEVTAGEEA QKECGSLLPD GTLQAFKLAR
110 120 130 140 150
VNLKGPLTTP VGGGFRSLNV TLRMVLDLYS NVRPVKWYGQ PTPHCHPENI
160 170 180 190 200
DWVIFRENTE DVYAGIEWPF DSPEAQKIRD FLKKEFGIEL TPDTGIGIKP
210 220 230 240 250
ISKWRTQRHV RRAMEWAIRN GYKHVTIMHK GNIMKYTEGA FRQWAYDLIL
260 270 280 290 300
SEFRDYVVTE EEVNTKYGGK APEGKIIVND RIADNMLQQI ITRPGEYNVI
310 320 330 340 350
VTPNLNGDYI SDEANALVGG IGMAAGLDMG DGIAVAEPVH GSAPKYAGKN
360 370 380 390 400
VINPTAEILS GMYLLSDFVG WPEVKLLVEY AVKQAIAHKQ VTYDLAREMG
410 420
GVTPISTTEY TDVLVDYIRH ADLKALKGQ
Length:429
Mass (Da):47,620
Last modified:May 1, 2000 - v2
Checksum:iF06A559FCAA1C42B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86855 Genomic DNA. Translation: BAA13177.2.
PIRiT44658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86855 Genomic DNA. Translation: BAA13177.2 .
PIRi T44658.

3D structure databases

ProteinModelPortali P96318.
SMRi P96318. Positions 3-423.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Eubacteria-type isocitrate dehydrogenase from an Archaeon: cloning, sequencing, and expression of a gene encoding isocitrate dehydrogenase from a hyperthermophilic archaebacterium Caldococcus noboribetus."
    Aoshima M., Yamagishi A., Oshima T.
    Arch. Biochem. Biophys. 336:77-85(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NC12.

Entry informationi

Entry nameiIDH_CALNO
AccessioniPrimary (citable) accession number: P96318
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: May 1, 2000
Last modified: October 1, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3