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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Caldococcus noboribetus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg2+ or Mn2+ ion per subunit.By similarity

Temperature dependencei

Optimum temperature is 98 degrees Celsius. Thermostable.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei108NADPBy similarity1
Binding sitei117SubstrateBy similarity1
Binding sitei119SubstrateBy similarity1
Binding sitei123SubstrateBy similarity1
Binding sitei133SubstrateBy similarity1
Binding sitei156SubstrateBy similarity1
Sitei163Critical for catalysisBy similarity1
Sitei230Critical for catalysisBy similarity1
Metal bindingi308Magnesium or manganeseBy similarity1
Binding sitei353NADP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei393NADPBy similarity1
Binding sitei397NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi340 – 346NADPBy similarity7

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Enzyme and pathway databases

BRENDAi1.1.1.42. 1058.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
OrganismiCaldococcus noboribetus
Taxonomic identifieri57174 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesCaldococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835731 – 429Isocitrate dehydrogenase [NADP]Add BLAST429

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP96318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 3 hits.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P96318-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSHPCTADE AKPPSEGQLA RFENGKLIVP DNLIVAYFKG DGIGPEIVES
60 70 80 90 100
AKKVLDAAVD KAYGGTRRIV WWEVTAGEEA QKECGSLLPD GTLQAFKLAR
110 120 130 140 150
VNLKGPLTTP VGGGFRSLNV TLRMVLDLYS NVRPVKWYGQ PTPHCHPENI
160 170 180 190 200
DWVIFRENTE DVYAGIEWPF DSPEAQKIRD FLKKEFGIEL TPDTGIGIKP
210 220 230 240 250
ISKWRTQRHV RRAMEWAIRN GYKHVTIMHK GNIMKYTEGA FRQWAYDLIL
260 270 280 290 300
SEFRDYVVTE EEVNTKYGGK APEGKIIVND RIADNMLQQI ITRPGEYNVI
310 320 330 340 350
VTPNLNGDYI SDEANALVGG IGMAAGLDMG DGIAVAEPVH GSAPKYAGKN
360 370 380 390 400
VINPTAEILS GMYLLSDFVG WPEVKLLVEY AVKQAIAHKQ VTYDLAREMG
410 420
GVTPISTTEY TDVLVDYIRH ADLKALKGQ
Length:429
Mass (Da):47,620
Last modified:May 1, 2000 - v2
Checksum:iF06A559FCAA1C42B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86855 Genomic DNA. Translation: BAA13177.2.
PIRiT44658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86855 Genomic DNA. Translation: BAA13177.2.
PIRiT44658.

3D structure databases

ProteinModelPortaliP96318.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi1.1.1.42. 1058.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 3 hits.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIDH_CALNO
AccessioniPrimary (citable) accession number: P96318
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: May 1, 2000
Last modified: October 5, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.