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Reviewed, UniProtKB/Swiss-Prot P96318 (IDH_CALNO)

Last modified November 25, 2008. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Isocitrate dehydrogenase [NADP]
      Short name=IDH
    EC=1.1.1.42
Alternative name(s):
    Oxalosuccinate decarboxylase
    NADP(+)-specific ICDH
    IDP
Gene names
Name: icd
OrganismCaldococcus noboribetus
Taxonomic identifier57174 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiDesulfurococcalesCaldococcus

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.

Oxalosuccinate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Biophysicochemical properties

Temperature dependence:

Optimum temperature is 98 degrees Celsius. Thermostable.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 429429Isocitrate dehydrogenase [NADP]
PRO_0000083573

Regions

Nucleotide binding340 – 3467NADP By similarity

Sites

Metal binding3081Magnesium or manganese By similarity
Binding site1081NADP By similarity
Binding site1171Substrate By similarity
Binding site1191Substrate By similarity
Binding site1231Substrate By similarity
Binding site1331Substrate By similarity
Binding site1561Substrate By similarity
Binding site3531NADP; via amide nitrogen and carbonyl oxygen By similarity
Binding site3931NADP By similarity
Binding site3971NADP By similarity
Site1631Critical for catalysis By similarity
Site2301Critical for catalysis By similarity

Amino acid modifications

Modified residue1171Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P96318-1 [UniParc].

Last modified May 1, 2000. Version 2.
Checksum: F06A559FCAA1C42B

FASTA42947,620
        10         20         30         40         50         60 
MVSHPCTADE AKPPSEGQLA RFENGKLIVP DNLIVAYFKG DGIGPEIVES AKKVLDAAVD 

        70         80         90        100        110        120 
KAYGGTRRIV WWEVTAGEEA QKECGSLLPD GTLQAFKLAR VNLKGPLTTP VGGGFRSLNV 

       130        140        150        160        170        180 
TLRMVLDLYS NVRPVKWYGQ PTPHCHPENI DWVIFRENTE DVYAGIEWPF DSPEAQKIRD 

       190        200        210        220        230        240 
FLKKEFGIEL TPDTGIGIKP ISKWRTQRHV RRAMEWAIRN GYKHVTIMHK GNIMKYTEGA 

       250        260        270        280        290        300 
FRQWAYDLIL SEFRDYVVTE EEVNTKYGGK APEGKIIVND RIADNMLQQI ITRPGEYNVI 

       310        320        330        340        350        360 
VTPNLNGDYI SDEANALVGG IGMAAGLDMG DGIAVAEPVH GSAPKYAGKN VINPTAEILS 

       370        380        390        400        410        420 
GMYLLSDFVG WPEVKLLVEY AVKQAIAHKQ VTYDLAREMG GVTPISTTEY TDVLVDYIRH 


ADLKALKGQ 

« Hide

References

[1]"Eubacteria-type isocitrate dehydrogenase from an Archaeon: cloning, sequencing, and expression of a gene encoding isocitrate dehydrogenase from a hyperthermophilic archaebacterium Caldococcus noboribetus."
Aoshima M., Yamagishi A., Oshima T.
Arch. Biochem. Biophys. 336:77-85(1996) [PubMed: 8951037] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: NC12.

Cross-references

Sequence databases

D86855 Genomic DNA. Translation: BAA13177.2.
PIRT44658.

3D structure databases

HSSPHSSP built from PDB template 1HQS based on UniProtKB P39126.
ModBaseSearch...

Family and domain databases

InterProIPR004439. IsoCit_DHase_NADP_prok.
IPR001804. IsoCit_IM_DHase.
[Graphical view]
Gene3DG3DSA:3.40.718.10. IDH_IMDH. 1 hit.
PANTHERPTHR11835. IDH_IMDH_dimeric. 1 hit.
PTHR11835:SF1. NADP_IDH_prok. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR00183. prok_nadp_idh. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIDH_CALNO
AccessionPrimary (citable) accession number: P96318
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: May 1, 2000
Last modified: November 25, 2008
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents