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P96318

- IDH_CALNO

UniProt

P96318 - IDH_CALNO

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Caldococcus noboribetus
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Temperature dependencei

    Optimum temperature is 98 degrees Celsius. Thermostable.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei108 – 1081NADPBy similarity
    Binding sitei117 – 1171SubstrateBy similarity
    Binding sitei119 – 1191SubstrateBy similarity
    Binding sitei123 – 1231SubstrateBy similarity
    Binding sitei133 – 1331SubstrateBy similarity
    Binding sitei156 – 1561SubstrateBy similarity
    Sitei163 – 1631Critical for catalysisBy similarity
    Sitei230 – 2301Critical for catalysisBy similarity
    Metal bindingi308 – 3081Magnesium or manganeseBy similarity
    Binding sitei353 – 3531NADP; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei393 – 3931NADPBy similarity
    Binding sitei397 – 3971NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi340 – 3467NADPBy similarity

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
    Short name:
    IDH
    Alternative name(s):
    IDP
    NADP(+)-specific ICDH
    Oxalosuccinate decarboxylase
    Gene namesi
    Name:icd
    OrganismiCaldococcus noboribetus
    Taxonomic identifieri57174 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesCaldococcus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 429429Isocitrate dehydrogenase [NADP]PRO_0000083573Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei117 – 1171PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP96318.
    SMRiP96318. Positions 3-423.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P96318-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSHPCTADE AKPPSEGQLA RFENGKLIVP DNLIVAYFKG DGIGPEIVES    50
    AKKVLDAAVD KAYGGTRRIV WWEVTAGEEA QKECGSLLPD GTLQAFKLAR 100
    VNLKGPLTTP VGGGFRSLNV TLRMVLDLYS NVRPVKWYGQ PTPHCHPENI 150
    DWVIFRENTE DVYAGIEWPF DSPEAQKIRD FLKKEFGIEL TPDTGIGIKP 200
    ISKWRTQRHV RRAMEWAIRN GYKHVTIMHK GNIMKYTEGA FRQWAYDLIL 250
    SEFRDYVVTE EEVNTKYGGK APEGKIIVND RIADNMLQQI ITRPGEYNVI 300
    VTPNLNGDYI SDEANALVGG IGMAAGLDMG DGIAVAEPVH GSAPKYAGKN 350
    VINPTAEILS GMYLLSDFVG WPEVKLLVEY AVKQAIAHKQ VTYDLAREMG 400
    GVTPISTTEY TDVLVDYIRH ADLKALKGQ 429
    Length:429
    Mass (Da):47,620
    Last modified:May 1, 2000 - v2
    Checksum:iF06A559FCAA1C42B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86855 Genomic DNA. Translation: BAA13177.2.
    PIRiT44658.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86855 Genomic DNA. Translation: BAA13177.2 .
    PIRi T44658.

    3D structure databases

    ProteinModelPortali P96318.
    SMRi P96318. Positions 3-423.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Eubacteria-type isocitrate dehydrogenase from an Archaeon: cloning, sequencing, and expression of a gene encoding isocitrate dehydrogenase from a hyperthermophilic archaebacterium Caldococcus noboribetus."
      Aoshima M., Yamagishi A., Oshima T.
      Arch. Biochem. Biophys. 336:77-85(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: NC12.

    Entry informationi

    Entry nameiIDH_CALNO
    AccessioniPrimary (citable) accession number: P96318
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3