ID   P96271_MYCTU            Unreviewed;      1539 AA.
AC   P96271; I6Y7S5; L0T3N8;
DT   01-MAY-1997, integrated into UniProtKB/TrEMBL.
DT   01-MAY-1997, sequence version 1.
DT   27-MAR-2024, entry version 158.
DE   SubName: Full=Possible metal cation transporting P-type ATPase CtpH {ECO:0000313|EMBL:CCP43156.1};
GN   Name=ctpH {ECO:0000313|EMBL:CCP43156.1};
GN   OrderedLocusNames=Rv0425c {ECO:0000313|EMBL:CCP43156.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332 {ECO:0000313|EMBL:CCP43156.1, ECO:0000313|Proteomes:UP000001584};
RN   [1] {ECO:0000313|EMBL:CCP43156.1, ECO:0000313|Proteomes:UP000001584}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv {ECO:0000313|Proteomes:UP000001584};
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III., Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L., Oliver K., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
RA   Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2] {ECO:0007829|PubMed:21969609}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21969609; DOI=10.1074/mcp.M111.011445;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000256|ARBA:ARBA00001836};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
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DR   EMBL; AL123456; CCP43156.1; -; Genomic_DNA.
DR   RefSeq; NP_214939.1; NC_000962.3.
DR   RefSeq; WP_003911174.1; NZ_NVQJ01000002.1.
DR   AlphaFoldDB; P96271; -.
DR   SMR; P96271; -.
DR   STRING; 83332.Rv0425c; -.
DR   PaxDb; 83332-Rv0425c; -.
DR   GeneID; 886373; -.
DR   KEGG; mtu:Rv0425c; -.
DR   PATRIC; fig|83332.111.peg.466; -.
DR   eggNOG; COG0474; Bacteria.
DR   InParanoid; P96271; -.
DR   OrthoDB; 9814270at2; -.
DR   PhylomeDB; P96271; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0005388; F:P-type calcium transporter activity; IBA:GO_Central.
DR   CDD; cd07539; P-type_ATPase; 1.
DR   Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR   Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR   Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR001757; P_typ_ATPase.
DR   InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR   NCBIfam; TIGR01494; ATPase_P-type; 2.
DR   PANTHER; PTHR42861; CALCIUM-TRANSPORTING ATPASE; 1.
DR   PANTHER; PTHR42861:SF31; PLASMA MEMBRANE ATPASE-RELATED; 1.
DR   Pfam; PF00689; Cation_ATPase_C; 1.
DR   Pfam; PF00122; E1-E2_ATPase; 1.
DR   Pfam; PF00702; Hydrolase; 1.
DR   PRINTS; PR00119; CATATPASE.
DR   PRINTS; PR00120; HATPASE.
DR   SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR   SFLD; SFLDF00027; p-type_atpase; 1.
DR   SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR   SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
PE   1: Evidence at protein level;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001584};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        1409..1432
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1444..1463
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1313..1463
FT                   /note="Cation-transporting P-type ATPase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00689"
FT   REGION          1469..1539
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1470..1484
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1515..1529
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1539 AA;  159773 MW;  27F76F9F0EB9FACF CRC64;
     MPVRAVATGF RATATLTGAS ITAATAVSAT LAKTGVGTGM KVAIIPLRAG AKALSGELSR
     ETLGRNCWRG ERRAWIEVRG LRSGGDDELG RVVLNAIQAH PGVGSASLNY PLSRVVVAID
     DPDTSLRELC RIVDDAEKAE RHRHPDQAAD QLAQSPGSLP GDGVLLAVRA VTVAATAAGL
     GLALGGRALR WPRFPLVIEA AVAAVDHQPL LRRLLEDRIG TEATATVLEL AMAAAHTVTL
     SPAALSVDLT IQALKAAECR AGARAWRRHE PQLALHADEP ADQPQSLWPR PARSTQPVQR
     SVARFALIQA LSAVLVGAGT RDADMAATAT LVATPKASRT TPEAFAAALG QGLADQHAVL
     PLRPESLRRL DRVDAIVIDP RVLCTDDLRV ARIRGCGADE LSTAWNRAQL VLTESGLRPG
     WHRVPGVSAS GSDSAVEALF RPMHDRLASA VVAEAHRTGA DLVSVDVDAL GELRPVFDDI
     RPLDDGASGS LDEALARAVA ELRQAGRTVA VLSSVGKQAL SAADVALGVL PPPGAGAPPW
     YADVLLPDLG AAWRVLHAIP AARAARQRGN EISGGASALG ALLMLPGVRG LGPGPVTTGA
     AAGLLSGYLL ARKVVDAQAP RPAPAHEWHA MSVEQVRKAL PSPDEQAPAK APPSPYPARA
     LAGGLHTAKR GAQITQAPLN ALWQLTKAMR AELSDPLTPM LALGAMASAV LGSPVDAVMV
     GSVLTGNSIL AASQRLRAES RLNRLLAQQI PPARKVLAGA DDQPRYIEVR AEELRPGDII
     EVRTHEVVPA DARVIEEVDV EVDESALTGE SLSVTKQVEP TPGVDLIERR CMLYAGTTVV
     SGTAVAVVTA VGPDTQERRA AELVSGDLSS VGLQHQLSRL TNQAWPVSMT GGALVTGLGL
     LRRRGLRQAV ASGIAVTVAA VPEGMPLVAT LAQQASARRL SHFGALVRIP RSVEALGRVD
     MVCFDKTGTL SENRLRVAQV RPVAGHSREE VLRCAAHAAP ASNGPQVHAT DVAIVQAAAA
     AAASGTDGAE PGAAEPAAHL PFRSGRSFSA SVSGTELTVK GAPEVVLAAC EGIGSSMDDA
     VAELAANGLR VIAVAHRQLT AQQAQSVVDD PDEIARLCRD ELSLVGFLGL SDTPRAQAAA
     LLADLHEHDL DIRLITGDHP ITAAAIAEEL GMQVSPEQVI SGAEWDALSR KDQERAVAER
     VIFARMTPEN KVQIVQTLEH SGRVCAMVGD GSNDAAAIRA ATVGIGVVAH GSDPARVAAD
     LVLVDGRIES LLPAILEGRQ LWQRVQAAVS VLLGGNAGEV AFAIIGSAIT GTSPLNTRQL
     LLVNMLTDAL PAAALAVSKP SDPVTPATRG PDQRELWRAV GIRGATTAAA ATVAWVMAGF
     TGLPRRASTV ALVALVAAQL GQTLVDSHAW LVVLTALGSL AALATLISIP VVSQLLGCTP
     LDPLGWAQAT AAATAATVAV AVLNRVLTGR DKSGQPNPQP PETDALSRDA SPGAPPGPRR
     RRRATARRKA PVKAPSATRQ TTKPKGPPAH RSSSTYPRR
//