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P96254 (PTA_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphate acetyltransferase
EC=2.3.1.8
Alternative name(s):
Phosphotransacetylase
Gene names
Name:pta
Ordered Locus Names:Rv0408, MT0421
ORF Names:MTCY22G10.04
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length690 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in acetate metabolism By similarity.

Catalytic activity

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathway

Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 2/2.

Subcellular location

Cytoplasm Potential.

Domain

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site By similarity.

Sequence similarities

In the N-terminal section; belongs to the CobB/CobQ family.

In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular region

Inferred from direct assay. Source: MTBBASE

   Molecular functionphosphate acetyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 690690Phosphate acetyltransferase
PRO_0000179135

Regions

Region365 – 690326Phosphate acetyltransferase

Sequences

Sequence LengthMass (Da)Tools
P96254 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: C01C412AF2810CCE

FASTA69072,949
        10         20         30         40         50         60 
MADSSAIYLA APESQTGKST IALGLLHRLT AMVAKVGVFR PITRLSAERD YILELLLAHT 

        70         80         90        100        110        120 
SAGLPYERCV GVTYQQLHAD RDDAIAEIVD SYHAMADECD AVVVVGSDYT DVTSPTELSV 

       130        140        150        160        170        180 
NGRIAVNLGA PVLLTVRAKD RTPDQVASVV EVCLAELDTQ RAHTAAVVAN RCELSAIPAV 

       190        200        210        220        230        240 
TDALRRFTPP SYVVPEEPLL SAPTVAELTQ AVNGAVVSGD VALREREVMG VLAAGMTADH 

       250        260        270        280        290        300 
VLERLTDGMA VITPGDRSDV VLAVASAHAA EGFPSLSCIV LNGGFQLHPA IAALVSGLRL 

       310        320        330        340        350        360 
RLPVIATALG TYDTASAAAS ARGLVTATSQ RKIDTALELM DRHVDVAGLL AQLTIPIPTV 

       370        380        390        400        410        420 
TTPQMFTYRL LQQARSDLMR IVLPEGDDDR ILKSAGRLLQ RGIVDLTILG DEAKVRLRAA 

       430        440        450        460        470        480 
ELGVDLDGAT VIEPCASELH DQFADQYAQL RKAKGITVEH AREIMNDATY FGTMLVHNCH 

       490        500        510        520        530        540 
ADGMVSGAAH TTAHTVRPAL EIIKTVPGIS TVSSIFLMCL PDRVLAYGDC AIIPNPTVEQ 

       550        560        570        580        590        600 
LADIAICSAR TAAQFGIEPR VAMLSYSTGD SGKGADVDKV RAATELVRAR EPQLPVEGPI 

       610        620        630        640        650        660 
QYDAAVEPSV AATKLRDSPV AGRATVLIFP DLNTGNNTYK AVQRSAGAIA IGPVLQGLRK 

       670        680        690 
PVNDLSRGAL VDDIVNTVAI TAIQAQGVHE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842573 Genomic DNA. Translation: CAB06578.1.
AE000516 Genomic DNA. Translation: AAK44645.1.
PIRF70628.
RefSeqNP_214922.1. NC_000962.2.
NP_334831.1. NC_002755.2.

3D structure databases

ProteinModelPortalP96254.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000001685; EBMYCP00000001685; EBMYCG00000001684.
EBMYCT00000072202; EBMYCP00000070261; EBMYCG00000072197.
GeneID886401.
923688.
GenomeReviewsGene locus MT0421 in contig AE000516_GR.
Gene locus Rv0408 in contig AL123456_GR.
KEGGmtc:MT0421.
mtu:Rv0408.
PATRIC18122644. VBIMycTub22151_0456.
TIGRMT0421.

Organism-specific databases

TubercuListRv0408.

Phylogenomic databases

GeneTreeEBGT00050000017507.
HOGENOMHBG576804.
OMAVTPLMFE.
PhylomeDBP96254.
ProtClustDBPRK05632.

Family and domain databases

InterProIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
[Graphical view]
KOK13788.
PfamPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFPIRSF006107. PhpActrans_proteobac. 1 hit.
TIGRFAMsTIGR00651. Pta. 1 hit.
ProtoNetSearch...

Entry information

Entry namePTA_MYCTU
AccessionPrimary (citable) accession number: P96254
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: January 25, 2012
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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