P96254 (PTA_MYCTU) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 84.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Phosphate acetyltransferase EC=2.3.1.8 Alternative name(s): Phosphotransacetylase | ||||||
| Gene names |
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| Organism | Mycobacterium tuberculosis | ||||||
| Taxonomic identifier | 1773 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex |
Protein attributes
| Sequence length | 690 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Involved in acetate metabolism By similarity. |
| Catalytic activity | Acetyl-CoA + phosphate = CoA + acetyl phosphate. |
| Pathway | Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 2/2. |
| Subcellular location | Cytoplasm Potential. |
| Domain | The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site By similarity. |
| Sequence similarities | In the N-terminal section; belongs to the CobB/CobQ family. In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Molecular function | Acyltransferase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular regionInferred from direct assay. Source: MTBBASE |
| Molecular function | phosphate acetyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. Barrell B.G.Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv. |
| [2] | "Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. Fraser C.M.J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX842573 Genomic DNA. Translation: CAB06578.1. AE000516 Genomic DNA. Translation: AAK44645.1. |
| PIR | F70628. |
| RefSeq | NP_214922.1. NC_000962.2. NP_334831.1. NC_002755.2. |
3D structure databases | |
| ProteinModelPortal | P96254. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBMYCT00000001685; EBMYCP00000001685; EBMYCG00000001684. EBMYCT00000072202; EBMYCP00000070261; EBMYCG00000072197. |
| GeneID | 886401. 923688. |
| GenomeReviews | Gene locus MT0421 in contig AE000516_GR. Gene locus Rv0408 in contig AL123456_GR. |
| KEGG | mtc:MT0421. mtu:Rv0408. |
| PATRIC | 18122644. VBIMycTub22151_0456. |
| TIGR | MT0421. |
Organism-specific databases | |
| TubercuList | Rv0408. |
Phylogenomic databases | |
| GeneTree | EBGT00050000017507. |
| HOGENOM | HBG576804. |
| OMA | VTPLMFE. |
| PhylomeDB | P96254. |
| ProtClustDB | PRK05632. |
Family and domain databases | |
| InterPro | IPR010766. DRTGG. IPR016475. P-Actrans_bac. IPR004614. P_AcTrfase. IPR002505. PTA_PTB. [Graphical view] |
| KO | K13788. |
| Pfam | PF07085. DRTGG. 1 hit. PF01515. PTA_PTB. 1 hit. [Graphical view] |
| PIRSF | PIRSF006107. PhpActrans_proteobac. 1 hit. |
| TIGRFAMs | TIGR00651. Pta. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PTA_MYCTU | ||||||||
| Accession | Primary (citable) accession number: P96254 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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