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P96188

- MTX1_XANCR

UniProt

P96188 - MTX1_XANCR

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Protein

Modification methylase XamI

Gene

xamIM

Organism
Xanthomonas campestris pv. amaranthicola
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GTCGAC, causes specific methylation on a-5 on both strands, and protects the DNA from cleavage by the XamI endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
  2. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi3526. M.XamI.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase XamI (EC:2.1.1.72)
Short name:
M.XamI
Alternative name(s):
Adenine-specific methyltransferase XamI
Gene namesi
Name:xamIM
OrganismiXanthomonas campestris pv. amaranthicola
Taxonomic identifieri54735 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Modification methylase XamIPRO_0000087983Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP96188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the N(4)/N(6)-methyltransferase family.Curated

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002296. N12N6_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PRINTSiPR00507. N12N6MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

P96188-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSMQTEQELV ALCLALIKDQ DSLSAAEKKL TKTTPVSALK PREIDTIRKR
60 70 80 90 100
SRAGLTHSAN VLFDPLGHRA PRAGAVYTPA PIVRSMMTWL AAQGSPARIV
110 120 130 140 150
DPGAGSGRFI LAAGEAFPDA QLVAVEMDPL AALMLRANLS ARGWTDRATV
160 170 180 190 200
MVKDYREVKL PPCAGITAFI GNPPYVRHHD IGEDWKAWYA SNFAGYGIKA
210 220 230 240 250
SALAGLHLHF FLQTRLLAKA GDVGAFITSA EWMDVNYGSA LRRLLLDELG
260 270 280 290 300
GIALHVLEPT VEAFPGTATT AAIACFRVGE TARPVRVRFI DELTNLNGLT
310 320 330 340 350
KGTDIPREQL QAASRWSIIV RPSAPAMAGD IELGELFRVH RGQVTGANGI
360 370 380 390 400
WIAGEHAQGL PDRVKMPAVT KAKDLIQAGA HLNSAEVLRR VIDLPTDLDD
410 420 430 440 450
FTKEERRRIS SFLSWAKLHG ADQSYIAQHR RAWWSVGLKA PAPILCTYMA
460 470 480 490 500
RRPPQFTLNA CDARHINIAH GLYPREPLAA GIMASLVTWL NKNINTGSGR
510 520
TYAGGLTKFE PKEIERLRIP SLENLHA
Length:527
Mass (Da):57,535
Last modified:May 1, 1997 - v1
Checksum:iB80C43CE684D8956
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U77781 Genomic DNA. Translation: AAD13686.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U77781 Genomic DNA. Translation: AAD13686.1 .

3D structure databases

ProteinModelPortali P96188.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 3526. M.XamI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR002296. N12N6_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PRINTSi PR00507. N12N6MTFRASE.
SUPFAMi SSF53335. SSF53335. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Isolation and nucleotide sequence of the gene encoding the XamI DNA methyltransferase of Xanthomonas campestris pv. amaranthicola."
    Gomez P., Ribas-Aparicio R.M., Pelaez A.I., Gomez A., Rodicio M.R.
    Biochim. Biophys. Acta 1351:261-266(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 11645 / LMG 498 / NCPPB 570.

Entry informationi

Entry nameiMTX1_XANCR
AccessioniPrimary (citable) accession number: P96188
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: May 1, 1997
Last modified: October 1, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3