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P96188

- MTX1_XANCR

UniProt

P96188 - MTX1_XANCR

Protein

Modification methylase XamI

Gene

xamIM

Organism
Xanthomonas campestris pv. amaranthicola
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    This methylase recognizes the double-stranded sequence GTCGAC, causes specific methylation on a-5 on both strands, and protects the DNA from cleavage by the XamI endonuclease.

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro
    2. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi3526. M.XamI.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Modification methylase XamI (EC:2.1.1.72)
    Short name:
    M.XamI
    Alternative name(s):
    Adenine-specific methyltransferase XamI
    Gene namesi
    Name:xamIM
    OrganismiXanthomonas campestris pv. amaranthicola
    Taxonomic identifieri54735 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 527527Modification methylase XamIPRO_0000087983Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP96188.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR002296. N12N6_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PRINTSiPR00507. N12N6MTFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P96188-1 [UniParc]FASTAAdd to Basket

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    MSMQTEQELV ALCLALIKDQ DSLSAAEKKL TKTTPVSALK PREIDTIRKR    50
    SRAGLTHSAN VLFDPLGHRA PRAGAVYTPA PIVRSMMTWL AAQGSPARIV 100
    DPGAGSGRFI LAAGEAFPDA QLVAVEMDPL AALMLRANLS ARGWTDRATV 150
    MVKDYREVKL PPCAGITAFI GNPPYVRHHD IGEDWKAWYA SNFAGYGIKA 200
    SALAGLHLHF FLQTRLLAKA GDVGAFITSA EWMDVNYGSA LRRLLLDELG 250
    GIALHVLEPT VEAFPGTATT AAIACFRVGE TARPVRVRFI DELTNLNGLT 300
    KGTDIPREQL QAASRWSIIV RPSAPAMAGD IELGELFRVH RGQVTGANGI 350
    WIAGEHAQGL PDRVKMPAVT KAKDLIQAGA HLNSAEVLRR VIDLPTDLDD 400
    FTKEERRRIS SFLSWAKLHG ADQSYIAQHR RAWWSVGLKA PAPILCTYMA 450
    RRPPQFTLNA CDARHINIAH GLYPREPLAA GIMASLVTWL NKNINTGSGR 500
    TYAGGLTKFE PKEIERLRIP SLENLHA 527
    Length:527
    Mass (Da):57,535
    Last modified:May 1, 1997 - v1
    Checksum:iB80C43CE684D8956
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77781 Genomic DNA. Translation: AAD13686.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77781 Genomic DNA. Translation: AAD13686.1 .

    3D structure databases

    ProteinModelPortali P96188.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    REBASEi 3526. M.XamI.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR002296. N12N6_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PRINTSi PR00507. N12N6MTFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and nucleotide sequence of the gene encoding the XamI DNA methyltransferase of Xanthomonas campestris pv. amaranthicola."
      Gomez P., Ribas-Aparicio R.M., Pelaez A.I., Gomez A., Rodicio M.R.
      Biochim. Biophys. Acta 1351:261-266(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 11645 / LMG 498 / NCPPB 570.

    Entry informationi

    Entry nameiMTX1_XANCR
    AccessioniPrimary (citable) accession number: P96188
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 8, 2000
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3