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P96188

- MTX1_XANCR

UniProt

P96188 - MTX1_XANCR

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Protein
Modification methylase XamI
Gene
xamIM
Organism
Xanthomonas campestris pv. amaranthicola
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GTCGAC, causes specific methylation on a-5 on both strands, and protects the DNA from cleavage by the XamI endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
  2. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi3526. M.XamI.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase XamI (EC:2.1.1.72)
Short name:
M.XamI
Alternative name(s):
Adenine-specific methyltransferase XamI
Gene namesi
Name:xamIM
OrganismiXanthomonas campestris pv. amaranthicola
Taxonomic identifieri54735 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Modification methylase XamI
PRO_0000087983Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP96188.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002296. N12N6_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PRINTSiPR00507. N12N6MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

P96188-1 [UniParc]FASTAAdd to Basket

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MSMQTEQELV ALCLALIKDQ DSLSAAEKKL TKTTPVSALK PREIDTIRKR    50
SRAGLTHSAN VLFDPLGHRA PRAGAVYTPA PIVRSMMTWL AAQGSPARIV 100
DPGAGSGRFI LAAGEAFPDA QLVAVEMDPL AALMLRANLS ARGWTDRATV 150
MVKDYREVKL PPCAGITAFI GNPPYVRHHD IGEDWKAWYA SNFAGYGIKA 200
SALAGLHLHF FLQTRLLAKA GDVGAFITSA EWMDVNYGSA LRRLLLDELG 250
GIALHVLEPT VEAFPGTATT AAIACFRVGE TARPVRVRFI DELTNLNGLT 300
KGTDIPREQL QAASRWSIIV RPSAPAMAGD IELGELFRVH RGQVTGANGI 350
WIAGEHAQGL PDRVKMPAVT KAKDLIQAGA HLNSAEVLRR VIDLPTDLDD 400
FTKEERRRIS SFLSWAKLHG ADQSYIAQHR RAWWSVGLKA PAPILCTYMA 450
RRPPQFTLNA CDARHINIAH GLYPREPLAA GIMASLVTWL NKNINTGSGR 500
TYAGGLTKFE PKEIERLRIP SLENLHA 527
Length:527
Mass (Da):57,535
Last modified:May 1, 1997 - v1
Checksum:iB80C43CE684D8956
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U77781 Genomic DNA. Translation: AAD13686.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U77781 Genomic DNA. Translation: AAD13686.1 .

3D structure databases

ProteinModelPortali P96188.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 3526. M.XamI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR002296. N12N6_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PRINTSi PR00507. N12N6MTFRASE.
SUPFAMi SSF53335. SSF53335. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Isolation and nucleotide sequence of the gene encoding the XamI DNA methyltransferase of Xanthomonas campestris pv. amaranthicola."
    Gomez P., Ribas-Aparicio R.M., Pelaez A.I., Gomez A., Rodicio M.R.
    Biochim. Biophys. Acta 1351:261-266(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 11645 / LMG 498 / NCPPB 570.

Entry informationi

Entry nameiMTX1_XANCR
AccessioniPrimary (citable) accession number: P96188
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: May 1, 1997
Last modified: June 11, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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