P96123 (CHEA_TREPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chemotaxis protein CheA
EC=2.7.13.3

Gene names

Name:	cheA
Ordered Locus Names:	TP_0363

Organism

Treponema pallidum (strain Nichols) [Complete proteome] [HAMAP]

Taxonomic identifier

243276 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length	812 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY By similarity.
Catalytic activity	ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Contains 1 cheW-like domain. Contains 1 histidine kinase domain. Contains 1 HPt domain.

Ontologies

Keywords
Biological process	Chemotaxis Two-component regulatory system
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular component movement Inferred from electronic annotation. Source: InterPro chemotaxis Inferred from electronic annotation. Source: UniProtKB-KW peptidyl-histidine phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW two-component sensor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 812	812	Chemotaxis protein CheA		PRO_0000074719
Regions
	Domain	1 – 111	111	HPt
	Domain	418 – 661	244	Histidine kinase
	Domain	663 – 798	136	CheW-like
Amino acid modifications
	Modified residue	54	1	Phosphohistidine; by autocatalysis By similarity
Experimental info
	Sequence conflict	428	1	G → E in AAC45555. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P96123 [UniParc]. Last modified December 15, 1998. Version 2. Checksum: 27EB51B5AD3A557D	FASTA	812	87,693
	10 20 30 40 50 60 MPMSDYLDAG NEELLKDFFS EAEQQVEQLE SNILVIEQDP TNRDAVDEIF RAAHTLKGGA 70 80 90 100 110 120 ATVEMHELSG FTHAVEDLLD GIRSEKVTVD GAVVDLLLTS LDVIKAMLES RAGGGPYAED 130 140 150 160 170 180 VSDLVARLRS YLPASGTVPG AARGLSVSSP NAAEAAKGTA VGEDGTEAPQ VGRVPPLSLL 190 200 210 220 230 240 SEYDRLELRE IVPPEHSVYA LTVRFDESNL MNTVGGIQVF TALKSCASVL KTVPDFDALY 250 260 270 280 290 300 QDMFHEYVVY FVSTVQDSVC VSQVASIPDV TLSVSVAEVA LADLCTPLSE HGELGVCADA 310 320 330 340 350 360 GTGGVSEGSG AAVRSGGERV PNSLPKQVAG CAVPSAKDSS KATSSGYGSG SVLRVDAKRI 370 380 390 400 410 420 DYLLNLVSET VIIKASLNQS ALEFGEVYTL FQNANGAYKE RLRKFFDRVP AYLEKVKNGQ 430 440 450 460 470 480 DADAVRKGMI AEAVGVFDIF SSFENGLKQS VTKFRSSAQN LGRISGELQE GVMKIRMVPI 490 500 510 520 530 540 SQIFSRYPRV VRDLSRDLRK EVRLVIEGEE TELDKSVVED LLDPIMHCVR NSLDHGIEAP 550 560 570 580 590 600 EVRARSGKPA QGTLLLRASN EGNMIVIEVA DDGRGIDVEA VKTKAVERGV LHPGKNLTEV 610 620 630 640 650 660 EAFQLIFAPG FSTSRSVSNV SGRGVGLDVV KTHIERLNGT VSVFSEVQKG TRFVIKLPLT 670 680 690 700 710 720 LAIIQGLLIR VGQEVYSIPI ASVIESHRIK SEEINRIDNY EVFNVRNEVI SLLRLDRLFG 730 740 750 760 770 780 ISCDDEVTGQ YHYVVIVGAA EKKVGLMVDA LIGEEDVVIK PLRDQFTSSP GIAGASILGD 790 800 810 GSVSLIIDVG QLLELGLKRE ILARERREAT VW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification, sequences, and expression of Treponema pallidum chemotaxis genes." Greene S.R., Stamm L.V., Hardham J.M., Young N.R., Frye J.G. DNA Seq. 7:267-284(1997) [PubMed: 9255518] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Nichols.
[2]	"Complete genome sequence of Treponema pallidum, the syphilis spirochete." Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K. , Chidambaram M., Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O., Venter J.C. Science 281:375-388(1998) [PubMed: 9665876] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nichols.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U61851 Genomic DNA. Translation: AAC45555.1. AE000520 Genomic DNA. Translation: AAC65348.1.
PIR	A71335.
RefSeq	NP_218803.1. NC_000919.1.
3D structure databases
ProteinModelPortal	P96123.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2611783.
GenomeReviews	Gene locus TP_0363 in contig AE000520_GR.
KEGG	tpa:TP0363.
NMPDR	fig|243276.1.peg.362.
PATRIC	20530727. VBITrePal57110_0384.
TIGR	TP_0363.
Phylogenomic databases
HOGENOM	HBG705053.
OMA	TELNETI.
ProtClustDB	CLSK375147.
Enzyme and pathway databases
BioCyc	TPAL243276:TP_0363-MONOMER.
BRENDA	2.7.13.3. 6429.
Family and domain databases
InterPro	IPR003594. ATPase-like_ATP-bd. IPR002545. CheW. IPR004358. Sig_transdc_His_kin-like_C. IPR008207. Sig_transdc_His_kin_Hpt_dom. IPR004105. Sig_transdc_His_kin_subgr_dim. IPR005467. Sig_transdc_His_kinase_core. IPR009082. Sig_transdc_His_kinase_dimeric. IPR010808. Sig_transdc_His_kinase_P2-bd. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit. G3DSA:3.30.70.1110. G3DSA:3.30.70.1110. 1 hit. G3DSA:1.20.120.160. Sig_transdc_His_kin_Hpt_dom. 1 hit. G3DSA:1.10.287.560. Sig_transdc_His_kin_subgr_dim. 1 hit.
KO	K03407.
Pfam	PF01584. CheW. 1 hit. PF02895. H-kinase_dim. 1 hit. PF02518. HATPase_c. 1 hit. PF01627. Hpt. 1 hit. PF07194. P2. 1 hit. [Graphical view]
PRINTS	PR00344. BCTRLSENSOR.
SMART	SM00260. CheW. 1 hit. SM00387. HATPase_c. 1 hit. SM00073. HPT. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF50341. CheW. 1 hit. SSF47384. His_kin_homodim. 1 hit. SSF47226. Hpt. 1 hit.
PROSITE	PS50851. CHEW. 1 hit. PS50109. HIS_KIN. 1 hit. PS50894. HPT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CHEA_TREPA

Accession

Primary (citable) accession number: P96123
Secondary accession number(s): O83381

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	December 15, 1998
Last modified:	January 25, 2012
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program