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Protein

Periplasmic zinc-binding protein TroA

Gene

troA

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of an ATP-driven transport system TroABCD for zinc. Substrate-binding protein involved in the transport of zinc across the cytoplasmic membrane.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi68Zinc1
Metal bindingi133Zinc1
Metal bindingi199Zinc1
Metal bindingi279Zinc1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

TCDBi3.A.1.15.8. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Periplasmic zinc-binding protein TroA
Alternative name(s):
Tromp-1
Gene namesi
Name:troA
Synonyms:troMP1
Ordered Locus Names:TP_0163
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000000811 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Add BLAST22
ChainiPRO_000003187223 – 308Periplasmic zinc-binding protein TroAAdd BLAST286

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

IntActiP96116. 8 interactors.
STRINGi243276.TP0163.

Structurei

Secondary structure

1308
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi35 – 40Combined sources6
Helixi41 – 51Combined sources11
Helixi52 – 54Combined sources3
Beta strandi55 – 60Combined sources6
Turni67 – 69Combined sources3
Helixi74 – 82Combined sources9
Beta strandi84 – 88Combined sources5
Turni91 – 94Combined sources4
Helixi95 – 97Combined sources3
Helixi98 – 104Combined sources7
Beta strandi107 – 112Combined sources6
Helixi113 – 116Combined sources4
Helixi119 – 121Combined sources3
Turni126 – 128Combined sources3
Helixi134 – 136Combined sources3
Helixi138 – 155Combined sources18
Helixi157 – 159Combined sources3
Helixi160 – 186Combined sources27
Helixi190 – 192Combined sources3
Beta strandi194 – 200Combined sources7
Helixi203 – 209Combined sources7
Beta strandi212 – 217Combined sources6
Beta strandi221 – 223Combined sources3
Helixi227 – 239Combined sources13
Beta strandi243 – 248Combined sources6
Helixi254 – 264Combined sources11
Turni265 – 267Combined sources3
Beta strandi271 – 276Combined sources6
Beta strandi278 – 280Combined sources3
Helixi287 – 289Combined sources3
Helixi291 – 306Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K0FX-ray2.50A32-308[»]
1TOAX-ray1.80A/B23-308[»]
ProteinModelPortaliP96116.
SMRiP96116.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP96116.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4107SIG. Bacteria.
COG0803. LUCA.
KOiK11707.
OMAiPHAWQTI.

Family and domain databases

InterProiIPR006129. AdhesinB.
IPR006128. Lipoprotein_4.
IPR006127. ZnuA-like.
[Graphical view]
PfamiPF01297. ZnuA. 1 hit.
[Graphical view]
PRINTSiPR00691. ADHESINB.
PR00690. ADHESNFAMILY.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P96116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRERICACV LALGMLTGFT HAFGSKDAAA DGKPLVVTTI GMIADAVKNI
60 70 80 90 100
AQGDVHLKGL MGPGVDPHLY TATAGDVEWL GNADLILYNG LHLETKMGEV
110 120 130 140 150
FSKLRGSRLV VAVSETIPVS QRLSLEEAEF DPHVWFDVKL WSYSVKAVYE
160 170 180 190 200
SLCKLLPGKT REFTQRYQAY QQQLDKLDAY VRRKAQSLPA ERRVLVTAHD
210 220 230 240 250
AFGYFSRAYG FEVKGLQGVS TASEASAHDM QELAAFIAQR KLPAIFIESS
260 270 280 290 300
IPHKNVEALR DAVQARGHVV QIGGELFSDA MGDAGTSEGT YVGMVTHNID

TIVAALAR
Length:308
Mass (Da):33,570
Last modified:May 1, 1997 - v1
Checksum:i2FDD8FF20D012B08
GO

Sequence cautioni

The sequence AAA92353 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16363 Genomic DNA. Translation: AAA92353.1. Different initiation.
U55214 Genomic DNA. Translation: AAC45725.1.
AE000520 Genomic DNA. Translation: AAC65151.1.
PIRiA71360.
RefSeqiWP_010881610.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65151; AAC65151; TP_0163.
GeneIDi2611122.
KEGGitpa:TP_0163.
PATRICi20530293. VBITrePal57110_0178.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16363 Genomic DNA. Translation: AAA92353.1. Different initiation.
U55214 Genomic DNA. Translation: AAC45725.1.
AE000520 Genomic DNA. Translation: AAC65151.1.
PIRiA71360.
RefSeqiWP_010881610.1. NC_021490.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K0FX-ray2.50A32-308[»]
1TOAX-ray1.80A/B23-308[»]
ProteinModelPortaliP96116.
SMRiP96116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP96116. 8 interactors.
STRINGi243276.TP0163.

Protein family/group databases

TCDBi3.A.1.15.8. the atp-binding cassette (abc) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC65151; AAC65151; TP_0163.
GeneIDi2611122.
KEGGitpa:TP_0163.
PATRICi20530293. VBITrePal57110_0178.

Phylogenomic databases

eggNOGiENOG4107SIG. Bacteria.
COG0803. LUCA.
KOiK11707.
OMAiPHAWQTI.

Miscellaneous databases

EvolutionaryTraceiP96116.

Family and domain databases

InterProiIPR006129. AdhesinB.
IPR006128. Lipoprotein_4.
IPR006127. ZnuA-like.
[Graphical view]
PfamiPF01297. ZnuA. 1 hit.
[Graphical view]
PRINTSiPR00691. ADHESINB.
PR00690. ADHESNFAMILY.
ProtoNetiSearch...

Entry informationi

Entry nameiTROA_TREPA
AccessioniPrimary (citable) accession number: P96116
Secondary accession number(s): Q56329
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be an outer membrane protein with porin-like properties.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.