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Protein

Periplasmic zinc-binding protein TroA

Gene

troA

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of an ATP-driven transport system TroABCD for zinc. Substrate-binding protein involved in the transport of zinc across the cytoplasmic membrane.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi68 – 681Zinc
Metal bindingi133 – 1331Zinc
Metal bindingi199 – 1991Zinc
Metal bindingi279 – 2791Zinc

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-173-MONOMER.

Protein family/group databases

TCDBi3.A.1.15.8. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Periplasmic zinc-binding protein TroA
Alternative name(s):
Tromp-1
Gene namesi
Name:troA
Synonyms:troMP1
Ordered Locus Names:TP_0163
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000000811 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Add
BLAST
Chaini23 – 308286Periplasmic zinc-binding protein TroAPRO_0000031872Add
BLAST

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

IntActiP96116. 8 interactions.
STRINGi243276.TP0163.

Structurei

Secondary structure

1
308
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi35 – 406Combined sources
Helixi41 – 5111Combined sources
Helixi52 – 543Combined sources
Beta strandi55 – 606Combined sources
Turni67 – 693Combined sources
Helixi74 – 829Combined sources
Beta strandi84 – 885Combined sources
Turni91 – 944Combined sources
Helixi95 – 973Combined sources
Helixi98 – 1047Combined sources
Beta strandi107 – 1126Combined sources
Helixi113 – 1164Combined sources
Helixi119 – 1213Combined sources
Turni126 – 1283Combined sources
Helixi134 – 1363Combined sources
Helixi138 – 15518Combined sources
Helixi157 – 1593Combined sources
Helixi160 – 18627Combined sources
Helixi190 – 1923Combined sources
Beta strandi194 – 2007Combined sources
Helixi203 – 2097Combined sources
Beta strandi212 – 2176Combined sources
Beta strandi221 – 2233Combined sources
Helixi227 – 23913Combined sources
Beta strandi243 – 2486Combined sources
Helixi254 – 26411Combined sources
Turni265 – 2673Combined sources
Beta strandi271 – 2766Combined sources
Beta strandi278 – 2803Combined sources
Helixi287 – 2893Combined sources
Helixi291 – 30616Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K0FX-ray2.50A32-308[»]
1TOAX-ray1.80A/B23-308[»]
ProteinModelPortaliP96116.
SMRiP96116. Positions 32-308.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP96116.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4107SIG. Bacteria.
COG0803. LUCA.
KOiK11707.
OMAiPHAWQTI.

Family and domain databases

InterProiIPR006129. AdhesinB.
IPR006128. Lipoprotein_4.
IPR006127. ZnuA-like.
[Graphical view]
PfamiPF01297. ZnuA. 1 hit.
[Graphical view]
PRINTSiPR00691. ADHESINB.
PR00690. ADHESNFAMILY.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P96116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRERICACV LALGMLTGFT HAFGSKDAAA DGKPLVVTTI GMIADAVKNI
60 70 80 90 100
AQGDVHLKGL MGPGVDPHLY TATAGDVEWL GNADLILYNG LHLETKMGEV
110 120 130 140 150
FSKLRGSRLV VAVSETIPVS QRLSLEEAEF DPHVWFDVKL WSYSVKAVYE
160 170 180 190 200
SLCKLLPGKT REFTQRYQAY QQQLDKLDAY VRRKAQSLPA ERRVLVTAHD
210 220 230 240 250
AFGYFSRAYG FEVKGLQGVS TASEASAHDM QELAAFIAQR KLPAIFIESS
260 270 280 290 300
IPHKNVEALR DAVQARGHVV QIGGELFSDA MGDAGTSEGT YVGMVTHNID

TIVAALAR
Length:308
Mass (Da):33,570
Last modified:May 1, 1997 - v1
Checksum:i2FDD8FF20D012B08
GO

Sequence cautioni

The sequence AAA92353 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16363 Genomic DNA. Translation: AAA92353.1. Different initiation.
U55214 Genomic DNA. Translation: AAC45725.1.
AE000520 Genomic DNA. Translation: AAC65151.1.
PIRiA71360.
RefSeqiWP_010881610.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65151; AAC65151; TP_0163.
GeneIDi2611122.
KEGGitpa:TP_0163.
PATRICi20530293. VBITrePal57110_0178.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16363 Genomic DNA. Translation: AAA92353.1. Different initiation.
U55214 Genomic DNA. Translation: AAC45725.1.
AE000520 Genomic DNA. Translation: AAC65151.1.
PIRiA71360.
RefSeqiWP_010881610.1. NC_021490.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K0FX-ray2.50A32-308[»]
1TOAX-ray1.80A/B23-308[»]
ProteinModelPortaliP96116.
SMRiP96116. Positions 32-308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP96116. 8 interactions.
STRINGi243276.TP0163.

Protein family/group databases

TCDBi3.A.1.15.8. the atp-binding cassette (abc) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC65151; AAC65151; TP_0163.
GeneIDi2611122.
KEGGitpa:TP_0163.
PATRICi20530293. VBITrePal57110_0178.

Phylogenomic databases

eggNOGiENOG4107SIG. Bacteria.
COG0803. LUCA.
KOiK11707.
OMAiPHAWQTI.

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-173-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP96116.

Family and domain databases

InterProiIPR006129. AdhesinB.
IPR006128. Lipoprotein_4.
IPR006127. ZnuA-like.
[Graphical view]
PfamiPF01297. ZnuA. 1 hit.
[Graphical view]
PRINTSiPR00691. ADHESINB.
PR00690. ADHESNFAMILY.
ProtoNetiSearch...

Entry informationi

Entry nameiTROA_TREPA
AccessioniPrimary (citable) accession number: P96116
Secondary accession number(s): Q56329
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be an outer membrane protein with porin-like properties.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.