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Protein

Glutamate dehydrogenase

Gene

gdhA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.PROSITE-ProRule annotation

Temperature dependencei

Optimum temperature is 75 degrees Celsius. Thermostable.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1051

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate dehydrogenase (EC:1.4.1.3)
Short name:
GDH
Gene namesi
Name:gdhA
Synonyms:gdh
Ordered Locus Names:TM_1015
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001827642 – 416Glutamate dehydrogenaseAdd BLAST415

Interactioni

Subunit structurei

Homohexamer.

Protein-protein interaction databases

STRINGi243274.TM1015.

Structurei

Secondary structure

1416
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 20Combined sources15
Helixi25 – 32Combined sources8
Beta strandi35 – 45Combined sources11
Beta strandi51 – 62Combined sources12
Beta strandi66 – 69Combined sources4
Beta strandi72 – 77Combined sources6
Helixi80 – 97Combined sources18
Beta strandi103 – 109Combined sources7
Helixi112 – 114Combined sources3
Helixi117 – 130Combined sources14
Helixi132 – 134Combined sources3
Turni137 – 139Combined sources3
Beta strandi140 – 143Combined sources4
Helixi150 – 164Combined sources15
Beta strandi171 – 174Combined sources4
Helixi177 – 179Combined sources3
Turni183 – 187Combined sources5
Helixi188 – 203Combined sources16
Turni208 – 210Combined sources3
Beta strandi212 – 216Combined sources5
Helixi220 – 231Combined sources12
Beta strandi236 – 241Combined sources6
Beta strandi246 – 248Combined sources3
Helixi255 – 264Combined sources10
Beta strandi265 – 268Combined sources4
Beta strandi272 – 277Combined sources6
Helixi279 – 282Combined sources4
Beta strandi288 – 292Combined sources5
Helixi301 – 304Combined sources4
Beta strandi310 – 313Combined sources4
Beta strandi316 – 318Combined sources3
Helixi322 – 330Combined sources9
Beta strandi334 – 336Combined sources3
Helixi338 – 341Combined sources4
Helixi344 – 357Combined sources14
Helixi364 – 389Combined sources26
Helixi393 – 411Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B26X-ray3.00A/B/C/D/E/F1-416[»]
1B3BX-ray3.10A/B/C/D/E/F2-416[»]
2TMGX-ray2.90A/B/C/D/E/F2-416[»]
ProteinModelPortaliP96110.
SMRiP96110.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP96110.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105D82. Bacteria.
COG0334. LUCA.
InParanoidiP96110.
KOiK00261.
OMAiNMIHASN.

Family and domain databases

CDDicd01076. NAD_bind_1_Glu_DH. 1 hit.
Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR033524. Glu/Leu/Phe/Val_DH_AS.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
IPR033922. NAD_bind_Glu_DH.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P96110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEKSLYEMA VEQFNRAASL MDLESDLAEV LRRPKRVLIV EFPVRMDDGH
60 70 80 90 100
VEVFTGYRVQ HNVARGPAKG GIRYHPDVTL DEVKALAFWM TWKTAVMNLP
110 120 130 140 150
FGGGKGGVRV DPKKLSRNEL ERLSRRFFSE IQVIIGPYND IPAPDVNTNA
160 170 180 190 200
DVMAWYMDTY SMNVGHTVLG IVTGKPVELG GSKGREEATG RGVKVCAGLA
210 220 230 240 250
MDVLGIDPKK ATVAVQGFGN VGQFAALLIS QELGSKVVAV SDSRGGIYNP
260 270 280 290 300
EGFDVEELIR YKKEHGTVVT YPKGERITNE ELLELDVDIL VPAALEGAIH
310 320 330 340 350
AGNAERIKAK AVVEGANGPT TPEADEILSR RGILVVPDIL ANAGGVTVSY
360 370 380 390 400
FEWVQDLQSF FWDLDQVRNA LEKMMKGAFN DVMKVKEKYN VDMRTAAYIL
410
AIDRVAYATK KRGIYP
Length:416
Mass (Da):45,821
Last modified:January 23, 2007 - v4
Checksum:iD7294929879CB4F2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153M → I in CAA71058 (PubMed:9680336).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09925 Genomic DNA. Translation: CAA71058.1.
AE000512 Genomic DNA. Translation: AAD36092.1.
PIRiG72305.
T45284.
RefSeqiNP_228821.1. NC_000853.1.
WP_004080520.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36092; AAD36092; TM_1015.
GeneIDi896847.
KEGGitma:TM1015.
PATRICi23936959. VBITheMar51294_1028.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09925 Genomic DNA. Translation: CAA71058.1.
AE000512 Genomic DNA. Translation: AAD36092.1.
PIRiG72305.
T45284.
RefSeqiNP_228821.1. NC_000853.1.
WP_004080520.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B26X-ray3.00A/B/C/D/E/F1-416[»]
1B3BX-ray3.10A/B/C/D/E/F2-416[»]
2TMGX-ray2.90A/B/C/D/E/F2-416[»]
ProteinModelPortaliP96110.
SMRiP96110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1015.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36092; AAD36092; TM_1015.
GeneIDi896847.
KEGGitma:TM1015.
PATRICi23936959. VBITheMar51294_1028.

Phylogenomic databases

eggNOGiENOG4105D82. Bacteria.
COG0334. LUCA.
InParanoidiP96110.
KOiK00261.
OMAiNMIHASN.

Miscellaneous databases

EvolutionaryTraceiP96110.

Family and domain databases

CDDicd01076. NAD_bind_1_Glu_DH. 1 hit.
Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR033524. Glu/Leu/Phe/Val_DH_AS.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
IPR033922. NAD_bind_Glu_DH.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHE3_THEMA
AccessioniPrimary (citable) accession number: P96110
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 124 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.