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P96108 (OTC_THEMA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ornithine carbamoyltransferase
Short name=OTCase
EC=2.1.3.3
Gene names
Name:argF
Ordered Locus Names:TM_1097
OrganismThermotoga maritima
Taxonomic identifier2336 [NCBI]
Taxonomic lineageBacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP MF_01109

Subcellular location

Cytoplasm Probable HAMAP MF_01109.

Sequence similarities

Belongs to the ATCase/OTCase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentornithine carbamoyltransferase complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionamino acid binding

Inferred from electronic annotation. Source: InterPro

ornithine carbamoyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Ornithine carbamoyltransferase HAMAP MF_01109
PRO_0000113049

Regions

Region57 – 615Carbamoyl phosphate binding By similarity
Region271 – 2744Ornithine binding By similarity

Sites

Binding site1081Carbamoyl phosphate By similarity
Binding site1351Carbamoyl phosphate By similarity
Site321Important for structural integrity By similarity
Site1481Important for structural integrity By similarity

Secondary structure

1 ........................................................ 313
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P96108 [UniParc].

Last modified July 1, 1997. Version 2.
Checksum: 0C813CAC3B8C6F8D

FASTA31335,362
        10         20         30         40         50         60 
MSVNLKGRSL LTLLDFSPEE IRYLLDISKQ VKMENRSKLR TERFKGMTLA MIFEKRSTRT 

        70         80         90        100        110        120 
RLAFETAFAE EGGHPIFLSP NDIHLGAKES LEDTARVLGR MVDAIMFRGY KQETVEKLAE 

       130        140        150        160        170        180 
YSGVPVYNGL TDEFHPTQAL ADLMTIEENF GRLKGVKVVF MGDTRNNVAT SLMIACAKMG 

       190        200        210        220        230        240 
MNFVACGPEE LKPRSDVFKR CQEIVKETDG SVSFTSNLEE ALAGADVVYT DVWASMGEED 

       250        260        270        280        290        300 
KEKERMALLK PYQVNERVME MTGKSETIFM HCLPAVKGQE VTYEVIEGKQ SRVWDEAENR 

       310 
KHTIKAVMIA TLL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Y10661 Genomic DNA. Translation: CAA71670.1.
AE000512 Genomic DNA. Translation: AAD36173.1.
PIRC72294.
RefSeqNP_228903.1. NC_000853.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1VLVX-ray2.25A1-313[»]
ProteinModelPortalP96108.
SMRP96108. Positions 1-313.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID898668.
GenomeReviewsGene locus TM_1097 in contig AE000512_GR.
KEGGtma:TM1097.
NMPDRfig|243274.1.peg.1087.
PATRIC23937129. VBITheMar51294_1113.
TIGRTM_1097.

Phylogenomic databases

HOGENOMHBG579429.
OMAFMTIKEH.
PhylomeDBP96108.
ProtClustDBPRK02102.

Enzyme and pathway databases

BioCycTMAR243274:TM_1097-MONOMER.

Family and domain databases

HAMAPMF_01109. OTCase.
[Tree]
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view]
KOK00611.
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMSSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMsTIGR00658. Orni_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOTC_THEMA
AccessionPrimary (citable) accession number: P96108
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: January 25, 2012
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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