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P96077

- RF1_THET8

UniProt

P96077 - RF1_THET8

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Protein
Peptide chain release factor 1
Gene
prfA, TTHA1940
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA By similarity.UniRule annotation

GO - Molecular functioni

  1. translation release factor activity, codon specific Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Biological processi

    Protein biosynthesis

    Enzyme and pathway databases

    BioCyciTTHE300852:GH8R-1990-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide chain release factor 1
    Short name:
    RF-1
    Gene namesi
    Name:prfA
    Ordered Locus Names:TTHA1940
    OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
    Taxonomic identifieri300852 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000532: Chromosome

    Subcellular locationi

    Cytoplasm By similarity UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 354354Peptide chain release factor 1UniRule annotation
    PRO_0000177762Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei230 – 2301N5-methylglutamine By similarity

    Post-translational modificationi

    Methylated by PrmC. Methylation increases the termination efficiency of RF1 By similarity.UniRule annotation

    Keywords - PTMi

    Methylation

    Interactioni

    Protein-protein interaction databases

    STRINGi300852.TTHA1940.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2B64X-ray5.90Y1-354[»]
    ProteinModelPortaliP96077.

    Miscellaneous databases

    EvolutionaryTraceiP96077.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0216.
    HOGENOMiHOG000074815.
    KOiK02835.
    OMAiYGQLKFE.
    OrthoDBiEOG6TN48J.
    PhylomeDBiP96077.

    Family and domain databases

    Gene3Di3.30.160.20. 1 hit.
    HAMAPiMF_00093. Rel_fac_1.
    InterProiIPR014720. dsRNA-bd_dom.
    IPR005139. PCRF.
    IPR000352. Pep_chain_release_fac_I_II.
    IPR004373. PrfA.
    [Graphical view]
    PfamiPF03462. PCRF. 1 hit.
    PF00472. RF-1. 1 hit.
    [Graphical view]
    SMARTiSM00937. PCRF. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00019. prfA. 1 hit.
    PROSITEiPS00745. RF_PROK_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P96077-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLDKLDRLEE EYRELEALLS DPEVLKDKGR YQSLSRRYAE MGEVIGLIRE    50
    YRKVLEDLEQ AESLLDDPEL KEMAKAEREA LLARKEALEK ELERHLLPKD 100
    PMDERDAIVE IRAGTGGEEA ALFARDLFNM YLRFAEEMGF ETEVLDSHPT 150
    DLGGFSKVVF EVRGPGAYGT FKYESGVHRV QRVPVTETQG RIHTSTATVA 200
    VLPKAEEEDF ALNMDEIRID VMRASGPGGQ GVNTTDSAVR VVHLPTGIMV 250
    TCQDSRSQIK NREKALMILR SRLLEMKRAE EAERLRKTRL AQIGTGERSE 300
    KIRTYNFPQS RVTDHRIGFT THDLEGVLSG HLTPILEALK RADQERQLAA 350
    LAEG 354
    Length:354
    Mass (Da):40,093
    Last modified:May 1, 1997 - v1
    Checksum:i49868D246BB3339E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87366 Genomic DNA. Translation: BAA13349.1.
    AP008226 Genomic DNA. Translation: BAD71763.1.
    RefSeqiWP_011173949.1. NC_006461.1.
    YP_145206.1. NC_006461.1.

    Genome annotation databases

    EnsemblBacteriaiBAD71763; BAD71763; BAD71763.
    GeneIDi3169506.
    KEGGittj:TTHA1940.
    PATRICi23958859. VBITheThe93045_1911.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87366 Genomic DNA. Translation: BAA13349.1 .
    AP008226 Genomic DNA. Translation: BAD71763.1 .
    RefSeqi WP_011173949.1. NC_006461.1.
    YP_145206.1. NC_006461.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2B64 X-ray 5.90 Y 1-354 [» ]
    ProteinModelPortali P96077.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 300852.TTHA1940.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD71763 ; BAD71763 ; BAD71763 .
    GeneIDi 3169506.
    KEGGi ttj:TTHA1940.
    PATRICi 23958859. VBITheThe93045_1911.

    Phylogenomic databases

    eggNOGi COG0216.
    HOGENOMi HOG000074815.
    KOi K02835.
    OMAi YGQLKFE.
    OrthoDBi EOG6TN48J.
    PhylomeDBi P96077.

    Enzyme and pathway databases

    BioCyci TTHE300852:GH8R-1990-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P96077.

    Family and domain databases

    Gene3Di 3.30.160.20. 1 hit.
    HAMAPi MF_00093. Rel_fac_1.
    InterProi IPR014720. dsRNA-bd_dom.
    IPR005139. PCRF.
    IPR000352. Pep_chain_release_fac_I_II.
    IPR004373. PrfA.
    [Graphical view ]
    Pfami PF03462. PCRF. 1 hit.
    PF00472. RF-1. 1 hit.
    [Graphical view ]
    SMARTi SM00937. PCRF. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00019. prfA. 1 hit.
    PROSITEi PS00745. RF_PROK_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Cloning of RF-1 gene from Thermus thermophilus HB8."
      Ito K., Ebihara K., Nakamura Y.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete genome sequence of Thermus thermophilus HB8."
      Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB8 / ATCC 27634 / DSM 579.

    Entry informationi

    Entry nameiRF1_THET8
    AccessioniPrimary (citable) accession number: P96077
    Secondary accession number(s): Q5SGZ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 1997
    Last modified: September 3, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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