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P96076 (PYRF_THET2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:TT_C1381
OrganismThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]
Taxonomic identifier262724 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' UMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

'de novo' pyrimidine nucleobase biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionorotidine-5'-phosphate decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01215
PRO_0000134635

Sites

Active site861Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
P96076 [UniParc].

Last modified May 24, 2004. Version 2.
Checksum: 806D562484B9F3EA

FASTA25727,436
        10         20         30         40         50         60 
MDFLEALSRP PLVLGVDPRP TLHGPEPLAH IRRYTLELLE ALAPRLAAAK FQLAFFEALG 

        70         80         90        100        110        120 
PEGTALLWEL ASASRVMGLP VIFDGKRGDI GSTAEAYARA YLEAFPGSAL TVNPYLGLDA 

       130        140        150        160        170        180 
LKPFFQAASR TGGGVFVLAK TSNPGSGFLQ DLLVEGKPLY LHLAEALERE GERYREGPWS 

       190        200        210        220        230        240 
RVGMVVGATY PEAVARVRER APHAPLLLPG VGAQGGRPLK GEGLLFAASR ALYYPGGRPD 

       250 
LKAALEAAEA LLKALVE 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of the extreme thermophile Thermus thermophilus."
Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J.
Nat. Biotechnol. 22:547-553(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB27 / ATCC BAA-163 / DSM 7039.
[2]"Pyrimidine biosynthesis genes (pyrE and pyrF) of an extreme thermophile, Thermus thermophilus."
Yamagishi A., Tanimoto T., Suzuki T., Oshima T.
Appl. Environ. Microbiol. 62:2191-2194(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-257.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017221 Genomic DNA. Translation: AAS81723.1.
D83330 Genomic DNA. Translation: BAA11885.1.
RefSeqYP_005350.1. NC_005835.1.

3D structure databases

ProteinModelPortalP96076.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262724.TTC1381.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS81723; AAS81723; TT_C1381.
GeneID2774890.
KEGGtth:TTC1381.
PATRIC23953175. VBITheThe54392_1374.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0284.
KOK01591.
OMAREGPWSR.
OrthoDBEOG6DZF33.

Enzyme and pathway databases

BioCycTTHE262724:GCAT-1398-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01215. OMPdecase_type2.
InterProIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR02127. pyrF_sub2. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_THET2
AccessionPrimary (citable) accession number: P96076
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 24, 2004
Last modified: May 14, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways