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P96076

- PYRF_THET2

UniProt

P96076 - PYRF_THET2

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (24 May 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei86 – 861Proton donorBy similarity

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciTTHE262724:GCAT-1398-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
    Alternative name(s):
    OMP decarboxylase
    Short name:
    OMPDCase
    Short name:
    OMPdecase
    Gene namesi
    Name:pyrF
    Ordered Locus Names:TT_C1381
    OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
    Taxonomic identifieri262724 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000592: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257Orotidine 5'-phosphate decarboxylasePRO_0000134635Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi262724.TTC1381.

    Structurei

    3D structure databases

    ProteinModelPortaliP96076.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0284.
    KOiK01591.
    OMAiREGPWSR.
    OrthoDBiEOG6DZF33.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01215. OMPdecase_type2.
    InterProiIPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR011995. OMPdecase_type-2.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P96076-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFLEALSRP PLVLGVDPRP TLHGPEPLAH IRRYTLELLE ALAPRLAAAK    50
    FQLAFFEALG PEGTALLWEL ASASRVMGLP VIFDGKRGDI GSTAEAYARA 100
    YLEAFPGSAL TVNPYLGLDA LKPFFQAASR TGGGVFVLAK TSNPGSGFLQ 150
    DLLVEGKPLY LHLAEALERE GERYREGPWS RVGMVVGATY PEAVARVRER 200
    APHAPLLLPG VGAQGGRPLK GEGLLFAASR ALYYPGGRPD LKAALEAAEA 250
    LLKALVE 257
    Length:257
    Mass (Da):27,436
    Last modified:May 24, 2004 - v2
    Checksum:i806D562484B9F3EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017221 Genomic DNA. Translation: AAS81723.1.
    D83330 Genomic DNA. Translation: BAA11885.1.
    RefSeqiWP_011173764.1. NC_005835.1.
    YP_005350.1. NC_005835.1.

    Genome annotation databases

    EnsemblBacteriaiAAS81723; AAS81723; TT_C1381.
    GeneIDi2774890.
    KEGGitth:TTC1381.
    PATRICi23953175. VBITheThe54392_1374.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017221 Genomic DNA. Translation: AAS81723.1 .
    D83330 Genomic DNA. Translation: BAA11885.1 .
    RefSeqi WP_011173764.1. NC_005835.1.
    YP_005350.1. NC_005835.1.

    3D structure databases

    ProteinModelPortali P96076.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262724.TTC1381.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS81723 ; AAS81723 ; TT_C1381 .
    GeneIDi 2774890.
    KEGGi tth:TTC1381.
    PATRICi 23953175. VBITheThe54392_1374.

    Phylogenomic databases

    eggNOGi COG0284.
    KOi K01591.
    OMAi REGPWSR.
    OrthoDBi EOG6DZF33.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci TTHE262724:GCAT-1398-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01215. OMPdecase_type2.
    InterProi IPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR011995. OMPdecase_type-2.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB27 / ATCC BAA-163 / DSM 7039.
    2. "Pyrimidine biosynthesis genes (pyrE and pyrF) of an extreme thermophile, Thermus thermophilus."
      Yamagishi A., Tanimoto T., Suzuki T., Oshima T.
      Appl. Environ. Microbiol. 62:2191-2194(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-257.

    Entry informationi

    Entry nameiPYRF_THET2
    AccessioniPrimary (citable) accession number: P96076
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 24, 2004
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3