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P96076

- PYRF_THET2

UniProt

P96076 - PYRF_THET2

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton donorBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1398-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:TT_C1381
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Orotidine 5'-phosphate decarboxylasePRO_0000134635Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262724.TTC1381.

Structurei

3D structure databases

ProteinModelPortaliP96076.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
KOiK01591.
OMAiREGPWSR.
OrthoDBiEOG6DZF33.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P96076-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFLEALSRP PLVLGVDPRP TLHGPEPLAH IRRYTLELLE ALAPRLAAAK
60 70 80 90 100
FQLAFFEALG PEGTALLWEL ASASRVMGLP VIFDGKRGDI GSTAEAYARA
110 120 130 140 150
YLEAFPGSAL TVNPYLGLDA LKPFFQAASR TGGGVFVLAK TSNPGSGFLQ
160 170 180 190 200
DLLVEGKPLY LHLAEALERE GERYREGPWS RVGMVVGATY PEAVARVRER
210 220 230 240 250
APHAPLLLPG VGAQGGRPLK GEGLLFAASR ALYYPGGRPD LKAALEAAEA

LLKALVE
Length:257
Mass (Da):27,436
Last modified:May 24, 2004 - v2
Checksum:i806D562484B9F3EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS81723.1.
D83330 Genomic DNA. Translation: BAA11885.1.
RefSeqiWP_011173764.1. NC_005835.1.
YP_005350.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS81723; AAS81723; TT_C1381.
GeneIDi2774890.
KEGGitth:TTC1381.
PATRICi23953175. VBITheThe54392_1374.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS81723.1 .
D83330 Genomic DNA. Translation: BAA11885.1 .
RefSeqi WP_011173764.1. NC_005835.1.
YP_005350.1. NC_005835.1.

3D structure databases

ProteinModelPortali P96076.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262724.TTC1381.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS81723 ; AAS81723 ; TT_C1381 .
GeneIDi 2774890.
KEGGi tth:TTC1381.
PATRICi 23953175. VBITheThe54392_1374.

Phylogenomic databases

eggNOGi COG0284.
KOi K01591.
OMAi REGPWSR.
OrthoDBi EOG6DZF33.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci TTHE262724:GCAT-1398-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.
  2. "Pyrimidine biosynthesis genes (pyrE and pyrF) of an extreme thermophile, Thermus thermophilus."
    Yamagishi A., Tanimoto T., Suzuki T., Oshima T.
    Appl. Environ. Microbiol. 62:2191-2194(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-257.

Entry informationi

Entry nameiPYRF_THET2
AccessioniPrimary (citable) accession number: P96076
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 24, 2004
Last modified: November 26, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3