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P95999 (GGPS_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Geranylgeranyl pyrophosphate synthase
Short name=GGPP synthase
Short name=GGPS
Alternative name(s):
(2E,6E)-farnesyl diphosphate synthase
Dimethylallyltranstransferase
EC=2.5.1.1
Farnesyl diphosphate synthase
Farnesyltranstransferase
EC=2.5.1.29
Geranyltranstransferase
EC=2.5.1.10
Gene names
Name:gds
Synonyms:gds-1
Ordered Locus Names:SSO0061
ORF Names:C05010, C05_049
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids.

Catalytic activity

Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.

Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.

(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.

Cofactor

Binds 3 magnesium ions per subunit By similarity.

Pathway

Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.

Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.

Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.

Sequence similarities

Belongs to the FPP/GGPP synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 332332Geranylgeranyl pyrophosphate synthase
PRO_0000123974

Sites

Metal binding841Magnesium 1 By similarity
Metal binding841Magnesium 2 By similarity
Metal binding881Magnesium 1 By similarity
Metal binding881Magnesium 2 By similarity
Metal binding2181Magnesium 3 By similarity
Binding site451Isopentenyl diphosphate By similarity
Binding site481Isopentenyl diphosphate By similarity
Binding site771Isopentenyl diphosphate By similarity
Binding site931Dimethylallyl diphosphate By similarity
Binding site941Isopentenyl diphosphate By similarity
Binding site1771Dimethylallyl diphosphate By similarity
Binding site1781Dimethylallyl diphosphate By similarity
Binding site2151Dimethylallyl diphosphate By similarity
Binding site2321Dimethylallyl diphosphate By similarity
Binding site2421Dimethylallyl diphosphate By similarity

Experimental info

Sequence conflict1221A → S in CAA69541. Ref.1
Sequence conflict1261A → S in CAA69541. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P95999 [UniParc].

Last modified June 20, 2001. Version 2.
Checksum: 2E3BEC59432CBD41

FASTA33237,228
        10         20         30         40         50         60 
MSSDDLSLYF NEIVNNVNFR IKNFVKSNFK TLEEASFHLF TAGGKRLRPL VLVSSSDLIG 

        70         80         90        100        110        120 
GDRERAYKAA AAVEILHNFT LVHDDIMDND GLRRGLPTVH VKWGEPMAIL AGDYLHAKAF 

       130        140        150        160        170        180 
EALNEALKGL DGNTFYKAFS IFITSIEIIS EGQAMDMSFE NRLDVTEEEY IQMIKGKTAM 

       190        200        210        220        230        240 
LFSCSAALGG IINKANDDVV KKLTEYGLNL GISFQIVDDI LGIIGDEKEL GKPIYSDIRE 

       250        260        270        280        290        300 
GKKTILVIKT LSEATEDEKK ILVSTLGNKE AKKEDLERAS EIIRKHSLQY AYDLAKKYSD 

       310        320        330 
LAIENLREIP VSNKTAEKAL KYLAQFTIQR RK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Y08257 Genomic DNA. Translation: CAA69541.1.
AE006641 Genomic DNA. Translation: AAK40423.1.
PIRH90145.
S75427.
RefSeqNP_341633.1. NC_002754.1.

3D structure databases

ProteinModelPortalP95999.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1455314.
GenomeReviewsGene locus SSO0061 in contig AE006641_GR.
KEGGsso:SSO0061.
NMPDRfig|273057.1.peg.56.

Phylogenomic databases

HOGENOMHBG732667.
OMALLYAKAF.
ProtClustDBCLSK802541.

Enzyme and pathway databases

BioCycSSOL273057:SSO0061-MONOMER.

Family and domain databases

InterProIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
Gene3DG3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
KOK13787.
PANTHERPTHR12001. Polyprenyl_synt. 1 hit.
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMSSF48576. Terpenoid_synth. 1 hit.
PROSITEPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGGPS_SULSO
AccessionPrimary (citable) accession number: P95999
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 20, 2001
Last modified: December 14, 2011
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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