Reviewed, UniProtKB/Swiss-Prot P95999 (GGPS_SULSO)

Names and origin

Protein names

Recommended name:
    Geranylgeranyl pyrophosphate synthetase
      Short name=GGPP synthetase
      Short name=GGPS
Including the following 3 domains:
    1- Recommended name:
            Dimethylallyltranstransferase
              EC=2.5.1.1
    2- Recommended name:
            Geranyltranstransferase
              EC=2.5.1.10
    3- Recommended name:
            Farnesyltranstransferase
              EC=2.5.1.29

Gene names

Name:	gds
Synonyms:	gds-1
Ordered Locus Names:	SSO0061
ORF Names:	C05010, C05_049

Organism

Sulfolobus solfataricus [Complete proteome] [HAMAP]

Taxonomic identifier

2287 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids.
Catalytic activity	Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate. Trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
Pathway	Isoprenoid biosynthesis; farnesyl-PP biosynthesis; farnesyl-PP from geranyl-PP and isopentenyl-PP: step 1/1. Isoprenoid biosynthesis; geranyl-PP biosynthesis; geranyl-PP from dimethylallyl-PP and isopentenyl-PP: step 1/1. Isoprenoid biosynthesis; geranylgeranyl-PP biosynthesis; geranylgeranyl-PP from farnesyl-PP and isopentenyl-PP: step 1/1.
Sequence similarities	Belongs to the FPP/GGPP synthetase family.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Lipid synthesis
Molecular function	Transferase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	dimethylallyltranstransferase activity Inferred from electronic annotation. Source: EC farnesyltranstransferase activity Inferred from electronic annotation. Source: EC geranyltranstransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Geranylgeranyl pyrophosphate synthetase		PRO_0000123974
Experimental info
	Sequence conflict	122	1	A → S in CAA69541. Ref.1
	Sequence conflict	126	1	A → S in CAA69541. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P95999-1 [UniParc]. Last modified June 20, 2001. Version 2. Checksum: 2E3BEC59432CBD41	FASTA	332	37,228
	10 20 30 40 50 60 MSSDDLSLYF NEIVNNVNFR IKNFVKSNFK TLEEASFHLF TAGGKRLRPL VLVSSSDLIG 70 80 90 100 110 120 GDRERAYKAA AAVEILHNFT LVHDDIMDND GLRRGLPTVH VKWGEPMAIL AGDYLHAKAF 130 140 150 160 170 180 EALNEALKGL DGNTFYKAFS IFITSIEIIS EGQAMDMSFE NRLDVTEEEY IQMIKGKTAM 190 200 210 220 230 240 LFSCSAALGG IINKANDDVV KKLTEYGLNL GISFQIVDDI LGIIGDEKEL GKPIYSDIRE 250 260 270 280 290 300 GKKTILVIKT LSEATEDEKK ILVSTLGNKE AKKEDLERAS EIIRKHSLQY AYDLAKKYSD 310 320 330 LAIENLREIP VSNKTAEKAL KYLAQFTIQR RK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Organizational characteristics and information content of an archaeal genome: 156 kb of sequence from Sulfolobus solfataricus P2." Sensen C.W., Klenk H.-P., Singh R.K., Allard G., Chan C.C.-Y., Liu Q.Y., Penny S.L., Young F., Schenk M.E., Gaasterland T., Doolittle W.F., Ragan M.A., Charlebois R.L. Mol. Microbiol. 22:175-191(1996) [PubMed: 8899719] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
[2]	"The complete genome of the crenarchaeon Sulfolobus solfataricus P2." She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. , Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T., Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J. Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed: 11427726] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y08257 Genomic DNA. Translation: CAA69541.1. AE006647 Genomic DNA. Translation: AAK40423.1.
PIR	H90145. S75427.
RefSeq	NP_341633.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1455314.
GenomeReviews	Gene locus SSO0061 in contig AE006641_GR.
KEGG	sso:SSO0061.
NMPDR	fig|273057.1.peg.56.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P95999.
Enzyme and pathway databases
BioCyc	SSOL273057:SSO0061-MON.
Family and domain databases
InterPro	IPR002197. HTH_Fis. IPR000092. Polyprenyl_synt. IPR017446. Polyprenyl_synth-rel. IPR008949. Terpenoid_synth. [Graphical view]
Gene3D	G3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PANTHER	PTHR12001. Polyprenyl_synt. 1 hit.
Pfam	PF00348. polyprenyl_synt. 1 hit. [Graphical view]
PRINTS	PR01590. HTHFIS.
PROSITE	PS00723. POLYPRENYL_SYNTHET_1. 1 hit. PS00444. POLYPRENYL_SYNTHET_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GGPS_SULSO

Accession

Primary (citable) accession number: P95999

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	June 20, 2001
Last modified:	November 25, 2008
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)