P95997 (IDI2_SULSO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Isopentenyl-diphosphate delta-isomerase
Short name=IPP isomerase
EC=5.3.3.2

Alternative name(s):
Isopentenyl pyrophosphate isomerase

Gene names

Name:	fni
Ordered Locus Names:	SSO0063
ORF Names:	C05008, C05_047

Organism

Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

Taxonomic identifier

273057 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	368 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00354
Catalytic activity	Isopentenyl diphosphate = dimethylallyl diphosphate. HAMAP MF_00354
Cofactor	FMN By similarity. HAMAP MF_00354 NADPH By similarity. HAMAP MF_00354
Subcellular location	Cytoplasm By similarity HAMAP MF_00354.
Sequence similarities	Belongs to the IPP isomerase type 2 family.

Ontologies

Keywords
Biological process	Isoprene biosynthesis
Cellular component	Cytoplasm
Ligand	FMN Flavoprotein NADP
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FMN binding Inferred from electronic annotation. Source: InterPro isopentenyl-diphosphate delta-isomerase activity Inferred from electronic annotation. Source: EC oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 368	368	Isopentenyl-diphosphate delta-isomerase HAMAP MF_00354		PRO_0000134455

Sequences

	Sequence		Length	Mass (Da)
	P95997 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 18E6687879E83826	FASTA	368	40,536
	10 20 30 40 50 60 MPDIVNRKVE HVEIAAFENV DGLSSSTFLN DVILVHQGFP GISFSEINTK TKFFRKEISA 70 80 90 100 110 120 PIMVTGMTGG RNELGRINRI IAEVAEKFGI PMGVGSQRVA IEKAEARESF TIVRKVAPTI 130 140 150 160 170 180 PIIANLGMPQ LVKGYGLKEF QDAIQMIEAD AIAVHLNPAQ EVFQPEGEPE YQIYALERLR 190 200 210 220 230 240 DISKELSVPI IVKESGNGIS METAKLLYSY GIKNFDTSGQ GGTNWIAIEM IRDIRRGNWK 250 260 270 280 290 300 AESAKNFLDW GVPTAASIIE VRYSIPDAFL VGSGGIRSGL DAAKAIALGA DIAGMALPVL 310 320 330 340 350 360 KSAIEGKESL EQFFRKIIFE LKATMMLTGS KNVEALKRSS IVILGKLKEW AEYRGINLSI YEKVRKRE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Organizational characteristics and information content of an archaeal genome: 156 kb of sequence from Sulfolobus solfataricus P2." Sensen C.W., Klenk H.-P., Singh R.K., Allard G., Chan C.C.-Y., Liu Q.Y., Penny S.L., Young F., Schenk M.E., Gaasterland T., Doolittle W.F., Ragan M.A., Charlebois R.L. Mol. Microbiol. 22:175-191(1996) [PubMed: 8899719] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
[2]	"The complete genome of the crenarchaeon Sulfolobus solfataricus P2." She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. , Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T., Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J. Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed: 11427726] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y08257 Genomic DNA. Translation: CAA69539.1. AE006641 Genomic DNA. Translation: AAK40424.1.
PIR	S75425.
RefSeq	NP_341634.1. NC_002754.1.
3D structure databases
ProteinModelPortal	P95997.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1455315.
GenomeReviews	Gene locus SSO0063 in contig AE006641_GR.
KEGG	sso:SSO0063.
NMPDR	fig|273057.1.peg.57.
Phylogenomic databases
HOGENOM	HBG354479.
OMA	GSQRAAI.
ProtClustDB	PRK05437.
Enzyme and pathway databases
BioCyc	SSOL273057:SSO0063-MONOMER.
Family and domain databases
HAMAP	MF_00354. Idi_2. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR000262. FMN-dep_DH. IPR011179. IPdP_isomerase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01823.
PANTHER	PTHR10578:SF3. IPdP_isomerase. 1 hit.
Pfam	PF01070. FMN_dh. 2 hits. [Graphical view]
PIRSF	PIRSF003314. IPP_isomerase. 1 hit.
TIGRFAMs	TIGR02151. IPP_isom_2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

IDI2_SULSO

Accession

Primary (citable) accession number: P95997

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 1997
Last modified:	November 16, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program