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Protein

Tyrosine--tRNA ligase

Gene

tyrS

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).UniRule annotation

Catalytic activityi

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41TyrosineUniRule annotation1
Binding sitei167TyrosineUniRule annotation1
Binding sitei171TyrosineUniRule annotation1
Binding sitei174TyrosineUniRule annotation1
Binding sitei189TyrosineUniRule annotation1
Binding sitei244ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine--tRNA ligaseUniRule annotation (EC:6.1.1.1UniRule annotation)
Alternative name(s):
Tyrosyl-tRNA synthetaseUniRule annotation
Short name:
TyrRSUniRule annotation
Gene namesi
Name:tyrSUniRule annotation
Ordered Locus Names:SSO0078
ORF Names:C04_044
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000556711 – 366Tyrosine--tRNA ligaseAdd BLAST366

Proteomic databases

PRIDEiP95982

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi273057.SSO0078

Structurei

3D structure databases

ProteinModelPortaliP95982
SMRiP95982
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi241 – 245"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01886 Archaea
COG0162 LUCA
HOGENOMiHOG000228238
InParanoidiP95982
KOiK01866
OMAiYIGFEIS
OrthoDBiPOG093Z05HU

Family and domain databases

CDDicd00805 TyrRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_02009 Tyr_tRNA_synth_type4, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002307 Tyr-tRNA-ligase
IPR023678 Tyr-tRNA-ligase_4
IPR023617 Tyr-tRNA-ligase_arc/euk-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PIRSFiPIRSF006588 TyrRS_arch_euk, 1 hit
PRINTSiPR01040 TRNASYNTHTYR
TIGRFAMsiTIGR00234 tyrS, 1 hit

Sequencei

Sequence statusi: Complete.

P95982-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKLIMSIDQ RLQLIMRNTA EVITIDELRK KLESDEKLKG YIGFEPSGLF
60 70 80 90 100
HIGWLIWTQK VKDLVEAGIN MTLLRAAWHA WINDKLGGDM NLIKMAADYA
110 120 130 140 150
VEVIKNYGVD VGKLNIVDAD DIVKEKDYWA LVIKVAKNAS LARIKRALTI
160 170 180 190 200
MGRRAEEAEI DASKLIYPAM QVSDIFYLDL DIALGGTDQR KAHMLARDVA
210 220 230 240 250
EKMGKKKIVS IHTPLLVGLQ GGQRMNITEG MEEDDIQAEI KMSKSKPESA
260 270 280 290 300
IFVNDSREDV ERKIMGAYCP KGVAENNPIL QILKYIIFPR YNFVKIERDI
310 320 330 340 350
KYGGDVEFKD YEELERTYIE GKIHPMDLKK TTARKLNEIL EPIRKSLEKK
360
PEFEEMIQKI SKSVTR
Length:366
Mass (Da):41,820
Last modified:May 1, 1997 - v1
Checksum:iC02CB985642A4D59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08257 Genomic DNA Translation: CAA69524.1
AE006641 Genomic DNA Translation: AAK40439.1
PIRiS75410

Genome annotation databases

EnsemblBacteriaiAAK40439; AAK40439; SSO0078
KEGGisso:SSO0078
PATRICifig|273057.12.peg.78

Similar proteinsi

Entry informationi

Entry nameiSYY_SULSO
AccessioniPrimary (citable) accession number: P95982
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
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