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Protein

Tyrosine--tRNA ligase

Gene

tyrS

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).UniRule annotation

Catalytic activityi

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411TyrosineUniRule annotation
Binding sitei167 – 1671TyrosineUniRule annotation
Binding sitei171 – 1711TyrosineUniRule annotation
Binding sitei174 – 1741TyrosineUniRule annotation
Binding sitei189 – 1891TyrosineUniRule annotation
Binding sitei244 – 2441ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-76-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine--tRNA ligaseUniRule annotation (EC:6.1.1.1UniRule annotation)
Alternative name(s):
Tyrosyl-tRNA synthetaseUniRule annotation
Short name:
TyrRSUniRule annotation
Gene namesi
Name:tyrSUniRule annotation
Ordered Locus Names:SSO0078
ORF Names:C04_044
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Tyrosine--tRNA ligasePRO_0000055671Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi273057.SSO0078.

Structurei

3D structure databases

ProteinModelPortaliP95982.
SMRiP95982. Positions 6-361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi241 – 2455"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01886. Archaea.
COG0162. LUCA.
HOGENOMiHOG000228238.
InParanoidiP95982.
KOiK01866.
OMAiFEYHVFP.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_02009. Tyr_tRNA_synth_type4.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002307. Tyr-tRNA-ligase.
IPR023678. Tyr-tRNA-ligase_4.
IPR023617. Tyr-tRNA-ligase_arc/euk-type.
[Graphical view]
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PIRSFiPIRSF006588. TyrRS_arch_euk. 1 hit.
PRINTSiPR01040. TRNASYNTHTYR.
TIGRFAMsiTIGR00234. tyrS. 1 hit.

Sequencei

Sequence statusi: Complete.

P95982-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKLIMSIDQ RLQLIMRNTA EVITIDELRK KLESDEKLKG YIGFEPSGLF
60 70 80 90 100
HIGWLIWTQK VKDLVEAGIN MTLLRAAWHA WINDKLGGDM NLIKMAADYA
110 120 130 140 150
VEVIKNYGVD VGKLNIVDAD DIVKEKDYWA LVIKVAKNAS LARIKRALTI
160 170 180 190 200
MGRRAEEAEI DASKLIYPAM QVSDIFYLDL DIALGGTDQR KAHMLARDVA
210 220 230 240 250
EKMGKKKIVS IHTPLLVGLQ GGQRMNITEG MEEDDIQAEI KMSKSKPESA
260 270 280 290 300
IFVNDSREDV ERKIMGAYCP KGVAENNPIL QILKYIIFPR YNFVKIERDI
310 320 330 340 350
KYGGDVEFKD YEELERTYIE GKIHPMDLKK TTARKLNEIL EPIRKSLEKK
360
PEFEEMIQKI SKSVTR
Length:366
Mass (Da):41,820
Last modified:May 1, 1997 - v1
Checksum:iC02CB985642A4D59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08257 Genomic DNA. Translation: CAA69524.1.
AE006641 Genomic DNA. Translation: AAK40439.1.
PIRiS75410.

Genome annotation databases

EnsemblBacteriaiAAK40439; AAK40439; SSO0078.
KEGGisso:SSO0078.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08257 Genomic DNA. Translation: CAA69524.1.
AE006641 Genomic DNA. Translation: AAK40439.1.
PIRiS75410.

3D structure databases

ProteinModelPortaliP95982.
SMRiP95982. Positions 6-361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO0078.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK40439; AAK40439; SSO0078.
KEGGisso:SSO0078.

Phylogenomic databases

eggNOGiarCOG01886. Archaea.
COG0162. LUCA.
HOGENOMiHOG000228238.
InParanoidiP95982.
KOiK01866.
OMAiFEYHVFP.

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-76-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_02009. Tyr_tRNA_synth_type4.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002307. Tyr-tRNA-ligase.
IPR023678. Tyr-tRNA-ligase_4.
IPR023617. Tyr-tRNA-ligase_arc/euk-type.
[Graphical view]
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PIRSFiPIRSF006588. TyrRS_arch_euk. 1 hit.
PRINTSiPR01040. TRNASYNTHTYR.
TIGRFAMsiTIGR00234. tyrS. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Organizational characteristics and information content of an archaeal genome: 156 kb of sequence from Sulfolobus solfataricus P2."
    Sensen C.W., Klenk H.-P., Singh R.K., Allard G., Chan C.C.-Y., Liu Q.Y., Penny S.L., Young F., Schenk M.E., Gaasterland T., Doolittle W.F., Ragan M.A., Charlebois R.L.
    Mol. Microbiol. 22:175-191(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiSYY_SULSO
AccessioniPrimary (citable) accession number: P95982
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.