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Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi399 – 3991Magnesium 1By similarity
Metal bindingi406 – 4061Magnesium 1By similarity
Metal bindingi406 – 4061Magnesium 2By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-85-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligase (EC:6.1.1.6)
Alternative name(s):
Lysyl-tRNA synthetase
Short name:
LysRS
Gene namesi
Name:lysS
Ordered Locus Names:SSO0090
ORF Names:C04_032
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Lysine--tRNA ligasePRO_0000152714Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0090.

Structurei

3D structure databases

ProteinModelPortaliP95970.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00408. Archaea.
COG1190. LUCA.
HOGENOMiHOG000236578.
InParanoidiP95970.
KOiK04567.
OMAiDMMNLTE.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00252. Lys_tRNA_synth_class2.
InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR002313. Lys-tRNA-ligase_II.
IPR018149. Lys-tRNA-synth_II_C.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PfamiPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PRINTSiPR00982. TRNASYNTHLYS.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00499. lysS_bact. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P95970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMNWDERRV KIVEELRKNG IEPYPHKYEV THLIKDIKLI AKSQGNKSHE
60 70 80 90 100
PFMFNISTAG RVANIRRHGK ASFVDIFDEG EKLQLYMRVD ELKEKYDKFF
110 120 130 140 150
IYVGRGDIIG VKGDLFYTMK GELSLLVKDY QLLSKALIEP PDWSKLSPEF
160 170 180 190 200
RYAHRYVDFL YNDNARKAME IRYTIIREIR EFLYSKGFIE VETPIVQPVY
210 220 230 240 250
GGALAKPFKT HVNYLNEDWY LRIALELYLK RYIIGGFNKV FEIGKVFRNE
260 270 280 290 300
DIDVTHNPEF TLLELYWAYA DYNDIMNLTE DLLKSVVKKV TNSTKIVYGK
310 320 330 340 350
YEIDFEGPFK RISMYDSLSE ILGKDVESMS DNELKELMKK YNLTPRGNQY
360 370 380 390 400
VRGLMIEKLF DKLVTPTLTN PTFITDYPIE TTPLCKPHRN KPGLVERFEM
410 420 430 440 450
FIAGMEVANA YTELNDPILQ DKLFREEQEM FRRGDEEAHP YDKDFVRALS
460 470 480 490
YGMPPTGGLG IGIDRIVMLV TNNYSIKEVI PFPMISSKVI LEDD
Length:494
Mass (Da):57,801
Last modified:May 1, 1997 - v1
Checksum:iAF19750B74CE2443
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08257 Genomic DNA. Translation: CAA69561.1.
AE006641 Genomic DNA. Translation: AAK40448.1.
PIRiS75398.

Genome annotation databases

EnsemblBacteriaiAAK40448; AAK40448; SSO0090.
KEGGisso:SSO0090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08257 Genomic DNA. Translation: CAA69561.1.
AE006641 Genomic DNA. Translation: AAK40448.1.
PIRiS75398.

3D structure databases

ProteinModelPortaliP95970.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO0090.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK40448; AAK40448; SSO0090.
KEGGisso:SSO0090.

Phylogenomic databases

eggNOGiarCOG00408. Archaea.
COG1190. LUCA.
HOGENOMiHOG000236578.
InParanoidiP95970.
KOiK04567.
OMAiDMMNLTE.

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-85-MONOMER.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00252. Lys_tRNA_synth_class2.
InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR002313. Lys-tRNA-ligase_II.
IPR018149. Lys-tRNA-synth_II_C.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PfamiPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PRINTSiPR00982. TRNASYNTHLYS.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00499. lysS_bact. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Organizational characteristics and information content of an archaeal genome: 156 kb of sequence from Sulfolobus solfataricus P2."
    Sensen C.W., Klenk H.-P., Singh R.K., Allard G., Chan C.C.-Y., Liu Q.Y., Penny S.L., Young F., Schenk M.E., Gaasterland T., Doolittle W.F., Ragan M.A., Charlebois R.L.
    Mol. Microbiol. 22:175-191(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiSYK_SULSO
AccessioniPrimary (citable) accession number: P95970
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 11, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.