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Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi399Magnesium 1By similarity1
Metal bindingi406Magnesium 1By similarity1
Metal bindingi406Magnesium 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligase (EC:6.1.1.6)
Alternative name(s):
Lysyl-tRNA synthetase
Short name:
LysRS
Gene namesi
Name:lysS
Ordered Locus Names:SSO0090
ORF Names:C04_032
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001527141 – 494Lysine--tRNA ligaseAdd BLAST494

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0090

Structurei

3D structure databases

ProteinModelPortaliP95970
SMRiP95970
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00408 Archaea
COG1190 LUCA
HOGENOMiHOG000236578
InParanoidiP95970
KOiK04567
OMAiMMNIIPG
OrthoDBiPOG093Z01MV

Family and domain databases

CDDicd00775 LysRS_core, 1 hit
HAMAPiMF_00252 Lys_tRNA_synth_class2, 1 hit
InterProiView protein in InterPro
IPR004364 aa-tRNA-synt_II
IPR006195 aa-tRNA-synth_II
IPR002313 Lys-tRNA-ligase_II
IPR018149 Lys-tRNA-synth_II_C
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA
PfamiView protein in Pfam
PF00152 tRNA-synt_2, 1 hit
PF01336 tRNA_anti-codon, 1 hit
PRINTSiPR00982 TRNASYNTHLYS
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00499 lysS_bact, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

P95970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMNWDERRV KIVEELRKNG IEPYPHKYEV THLIKDIKLI AKSQGNKSHE
60 70 80 90 100
PFMFNISTAG RVANIRRHGK ASFVDIFDEG EKLQLYMRVD ELKEKYDKFF
110 120 130 140 150
IYVGRGDIIG VKGDLFYTMK GELSLLVKDY QLLSKALIEP PDWSKLSPEF
160 170 180 190 200
RYAHRYVDFL YNDNARKAME IRYTIIREIR EFLYSKGFIE VETPIVQPVY
210 220 230 240 250
GGALAKPFKT HVNYLNEDWY LRIALELYLK RYIIGGFNKV FEIGKVFRNE
260 270 280 290 300
DIDVTHNPEF TLLELYWAYA DYNDIMNLTE DLLKSVVKKV TNSTKIVYGK
310 320 330 340 350
YEIDFEGPFK RISMYDSLSE ILGKDVESMS DNELKELMKK YNLTPRGNQY
360 370 380 390 400
VRGLMIEKLF DKLVTPTLTN PTFITDYPIE TTPLCKPHRN KPGLVERFEM
410 420 430 440 450
FIAGMEVANA YTELNDPILQ DKLFREEQEM FRRGDEEAHP YDKDFVRALS
460 470 480 490
YGMPPTGGLG IGIDRIVMLV TNNYSIKEVI PFPMISSKVI LEDD
Length:494
Mass (Da):57,801
Last modified:May 1, 1997 - v1
Checksum:iAF19750B74CE2443
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08257 Genomic DNA Translation: CAA69561.1
AE006641 Genomic DNA Translation: AAK40448.1
PIRiS75398

Genome annotation databases

EnsemblBacteriaiAAK40448; AAK40448; SSO0090
KEGGisso:SSO0090
PATRICifig|273057.12.peg.87

Similar proteinsi

Entry informationi

Entry nameiSYK_SULSO
AccessioniPrimary (citable) accession number: P95970
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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