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P95968 (SYE_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate--tRNA ligase

EC=6.1.1.17
Alternative name(s):
Glutamyl-tRNA synthetase
Short name=GluRS
Gene names
Name:gltX
Ordered Locus Names:SSO0093
ORF Names:C04029, C05_017
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [Reference proteome] [HAMAP]
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length575 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity. HAMAP-Rule MF_00022

Catalytic activity

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). HAMAP-Rule MF_00022

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00022.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutamyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glutamate-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 575575Glutamate--tRNA ligase HAMAP-Rule MF_00022
PRO_0000119731

Regions

Motif108 – 11811"HIGH" region HAMAP-Rule MF_00022

Sequences

Sequence LengthMass (Da)Tools
P95968 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 150D562D4BFED19E

FASTA57566,805
        10         20         30         40         50         60 
MMELNELRET IYKYALQNAV KHNGKAETGP VMSKIIAERP ELRSNAREIV KIIKEIIEQV 

        70         80         90        100        110        120 
NSLTLEQQLT EIKAKYPELL EEKKHEEKRK VLPPLPNVKG QVVTRFAPNP DGPLHLGNAR 

       130        140        150        160        170        180 
SAILSYEYAK MYNGKFILRF DDTDPKVKRP ILDAYDWIKE DLKWLGIKWE QELYASERLE 

       190        200        210        220        230        240 
LYYKYARYLI EKGYAYVDTC DSSIFRKFRD SRGKMKEPEC LHRSSSPESN LELFEKMLGG 

       250        260        270        280        290        300 
KFKEGEAVVR LKTDLSDPDP SQIDWVMLRI IDTAKNPHPR VGSKYWVWPT YNFASIIDDH 

       310        320        330        340        350        360 
ELGITHVLRA KEHMSNTEKQ RYISEYMGWE FPEVLQFGRL RLEGFMMSKS KIRGMLEKGT 

       370        380        390        400        410        420 
NRDDPRLPTL AGLRRRGILP DTIKDVIIDV GVKVTDATIS FENIAAINRK KLDPVAKRIM 

       430        440        450        460        470        480 
FVKDAEEFSV ELPESLNAKI PLIPSKQEMN RTIIVNPGDK ILIESNDAED NSILRLMELC 

       490        500        510        520        530        540 
NVKVDKHNRK LIFHSKTLDE AKKVNAKIVQ WVKSNEKVPV MVEKAERDEI KMINGYAEKI 

       550        560        570 
AADLEIDEIV QFYRFGFVRV DRKDENMLRV VFSHD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y08257 Genomic DNA. Translation: CAA69558.1.
AE006641 Genomic DNA. Translation: AAK40450.1.
PIRS75395.
RefSeqNP_341660.1. NC_002754.1.

3D structure databases

ProteinModelPortalP95968.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273057.SSO0093.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK40450; AAK40450; SSO0093.
GeneID1453278.
KEGGsso:SSO0093.

Phylogenomic databases

eggNOGCOG0008.
HOGENOMHOG000073585.
KOK01885.
OMAMRFAPNP.
ProtClustDBPRK04156.

Enzyme and pathway databases

BioCycSSOL273057:GCH2-88-MONOMER.

Family and domain databases

Gene3D1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPMF_00022_A. Glu_tRNA_synth_A.
InterProIPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR10119. PTHR10119. 1 hit.
PfamPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSPR00987. TRNASYNTHGLU.
SUPFAMSSF50715. SSF50715. 1 hit.
TIGRFAMsTIGR00463. gltX_arch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYE_SULSO
AccessionPrimary (citable) accession number: P95968
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: February 19, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries