P95907 (GLPK2_SULSO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycerol kinase 2
EC=2.7.1.30

Alternative name(s):
ATP:glycerol 3-phosphotransferase 2
Glycerokinase 2
Short name=GK 2

Gene names

Name:	glpK2
Synonyms:	glpK
Ordered Locus Names:	SSO2133
ORF Names:	C01009, C02_028

Organism

Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

Taxonomic identifier

273057 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	499 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186
Catalytic activity	ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycerol kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 499	499	Glycerol kinase 2 HAMAP MF_00186		PRO_0000059534
Regions
	Nucleotide binding	407 – 411	5	ATP By similarity
Sites
	Binding site	13	1	Substrate By similarity
	Binding site	17	1	ATP By similarity
	Binding site	83	1	Substrate By similarity
	Binding site	134	1	Substrate By similarity
	Binding site	241	1	Substrate By similarity
	Binding site	263	1	ATP By similarity
	Binding site	306	1	ATP; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	P95907 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 932B3096774E5FAC	FASTA	499	55,643
	10 20 30 40 50 60 MPGGFILAID EGTTSARAII YNQDLEVLGI GQYDFPQHYP SPGYVEHNPD EIWNAQMLAI 70 80 90 100 110 120 KEAMKKAKIE SRQVAGIGVT NQRETTILWD AISGKPIYNA IVWQDRRTSN ITDWLKENYF 130 140 150 160 170 180 GMIKDKTGLI PDPYFSGSKI KWILDNLPNV RSKAEKGEIK FGTIDTYLIW KLTNGKIHVT 190 200 210 220 230 240 DYSNASRTML FNINKLEWDR EILELLKIPE SILPEVRPSS DIYGYTEVLG SSIPISGDAG 250 260 270 280 290 300 DQQAALFGQV AYDMGEVKST YGTGSFILMN IGSNPIFSEN LLTTIAWGLE SKRVTYALEG 310 320 330 340 350 360 SIFITGAAVQ WFRDGLRAID ASDDIEPLAA SVPDTGGVYF VPAFVGLGAP YWDPYARGLI 370 380 390 400 410 420 IGITRGTTKA HIARAILESI AYQNRDVIEI MEKESGTKIN ILKVDGGGAK DNLLMQFQAD 430 440 450 460 470 480 ILGIRVVRPK VMETASMGVA MLAGLAINYW NSLNELKQKW TVDKEFIPSI NKEERERRYN 490 AWKEAVKRSL GWEKSLGSK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Organizational characteristics and information content of an archaeal genome: 156 kb of sequence from Sulfolobus solfataricus P2." Sensen C.W., Klenk H.-P., Singh R.K., Allard G., Chan C.C.-Y., Liu Q.Y., Penny S.L., Young F., Schenk M.E., Gaasterland T., Doolittle W.F., Ragan M.A., Charlebois R.L. Mol. Microbiol. 22:175-191(1996) [PubMed: 8899719] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
[2]	"The complete genome of the crenarchaeon Sulfolobus solfataricus P2." She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. , Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T., Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J. Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed: 11427726] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y08256 Genomic DNA. Translation: CAA69459.1. AE006641 Genomic DNA. Translation: AAK42312.1.
PIR	S74045.
RefSeq	NP_343522.1. NC_002754.1.
3D structure databases
ProteinModelPortal	P95907.
SMR	P95907. Positions 5-498.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1453639.
GenomeReviews	Gene locus SSO2133 in contig AE006641_GR.
KEGG	sso:SSO2133.
NMPDR	fig|273057.1.peg.1945.
Phylogenomic databases
HOGENOM	HBG511469.
OMA	QATESET.
ProtClustDB	CLSK268256.
Enzyme and pathway databases
BioCyc	SSOL273057:SSO2133-MONOMER.
Family and domain databases
HAMAP	MF_00186. Glycerol_kin. [Tree]
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR005999. Glycerol_kin. [Graphical view]
KO	K00864.
PANTHER	PTHR10196. FGGY_kin. 1 hit. PTHR10196:SF9. Glycerol_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01311. Glycerol_kin. 1 hit.
PROSITE	PS00933. FGGY_KINASES_1. 1 hit. PS00445. FGGY_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPK2_SULSO

Accession

Primary (citable) accession number: P95907

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1997
Last modified:	December 14, 2011
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program