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P95872

- RIB7_SULSO

UniProt

P95872 - RIB7_SULSO

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Protein

2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase

Gene
SSO2097, C06025, C06_008
Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate By similarity.

Catalytic activityi

2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + NAD(P)+ = 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NAD(P)H.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531NADP By similarity
Binding sitei57 – 571NADP By similarity
Binding sitei122 – 1221NADP; via amide nitrogen and carbonyl oxygen

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi79 – 824NADP By similarity
Nucleotide bindingi145 – 1484NADP By similarity

GO - Molecular functioni

  1. 5-amino-6-(5-phosphoribosylamino)uracil reductase activity Source: InterPro
  2. NADP binding Source: InterPro

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Riboflavin biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-1962-MONOMER.
UniPathwayiUPA00275.

Names & Taxonomyi

Protein namesi
Recommended name:
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase (EC:1.1.1.302)
Short name:
DAROPP reductase
Short name:
DARP reductase
Alternative name(s):
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase
2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase
Short name:
DARIPP synthase
Gene namesi
Ordered Locus Names:SSO2097
ORF Names:C06025, C06_008
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001974: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2132132,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductasePRO_0000135946Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi273057.SSO2097.

Structurei

3D structure databases

ProteinModelPortaliP95872.

Family & Domainsi

Sequence similaritiesi

Belongs to the HTP reductase family.

Phylogenomic databases

eggNOGiCOG1985.
HOGENOMiHOG000225965.
KOiK14654.
OMAiKPYVISN.

Family and domain databases

Gene3Di3.40.430.10. 1 hit.
InterProiIPR024072. DHFR-like_dom.
IPR006401. Rib_reduct_arc.
IPR011549. RibD_C.
IPR002734. RibDG_C.
[Graphical view]
PfamiPF01872. RibD_C. 1 hit.
[Graphical view]
SUPFAMiSSF53597. SSF53597. 1 hit.
TIGRFAMsiTIGR01508. rib_reduct_arch. 1 hit.
TIGR00227. ribD_Cterm. 1 hit.

Sequencei

Sequence statusi: Complete.

P95872-1 [UniParc]FASTAAdd to Basket

« Hide

MVMKPYVIIF STVSIDGRLA TKTGYSELSC PYDKQRQHEI RSEVDAVMVG    50
ANTVRVDNPS LTVKYGKNRR NPIRVVVTRS FNLDPSYKIF TTPPSTVIYT 100
SNYESEKVEE FIRKGVIVRK FLHLDDLLED LYDNFNVRRL MVEGGGHLIW 150
WFIKDNLYDE IRITISPRIF GNGVSFTQGE GFIGEDSPRL ELIDAKICEC 200
GNEVHLTYKK YMT 213
Length:213
Mass (Da):24,561
Last modified:May 1, 1997 - v1
Checksum:iA741F6CADEF7631C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08256 Genomic DNA. Translation: CAA69508.1.
AE006641 Genomic DNA. Translation: AAK42277.1.
PIRiS74011.
RefSeqiNP_343487.1. NC_002754.1.
WP_010923770.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK42277; AAK42277; SSO2097.
GeneIDi1453604.
KEGGisso:SSO2097.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08256 Genomic DNA. Translation: CAA69508.1 .
AE006641 Genomic DNA. Translation: AAK42277.1 .
PIRi S74011.
RefSeqi NP_343487.1. NC_002754.1.
WP_010923770.1. NC_002754.1.

3D structure databases

ProteinModelPortali P95872.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273057.SSO2097.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK42277 ; AAK42277 ; SSO2097 .
GeneIDi 1453604.
KEGGi sso:SSO2097.

Phylogenomic databases

eggNOGi COG1985.
HOGENOMi HOG000225965.
KOi K14654.
OMAi KPYVISN.

Enzyme and pathway databases

UniPathwayi UPA00275 .
BioCyci SSOL273057:GCH2-1962-MONOMER.

Family and domain databases

Gene3Di 3.40.430.10. 1 hit.
InterProi IPR024072. DHFR-like_dom.
IPR006401. Rib_reduct_arc.
IPR011549. RibD_C.
IPR002734. RibDG_C.
[Graphical view ]
Pfami PF01872. RibD_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53597. SSF53597. 1 hit.
TIGRFAMsi TIGR01508. rib_reduct_arch. 1 hit.
TIGR00227. ribD_Cterm. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Organizational characteristics and information content of an archaeal genome: 156 kb of sequence from Sulfolobus solfataricus P2."
    Sensen C.W., Klenk H.-P., Singh R.K., Allard G., Chan C.C.-Y., Liu Q.Y., Penny S.L., Young F., Schenk M.E., Gaasterland T., Doolittle W.F., Ragan M.A., Charlebois R.L.
    Mol. Microbiol. 22:175-191(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiRIB7_SULSO
AccessioniPrimary (citable) accession number: P95872
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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