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P95872

- RIB7_SULSO

UniProt

P95872 - RIB7_SULSO

Protein

2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase

Gene

SSO2097

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.By similarity

    Catalytic activityi

    2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + NAD(P)+ = 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NAD(P)H.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei53 – 531NADPBy similarity
    Binding sitei57 – 571NADPBy similarity
    Binding sitei122 – 1221NADP; via amide nitrogen and carbonyl oxygen

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi79 – 824NADPBy similarity
    Nucleotide bindingi145 – 1484NADPBy similarity

    GO - Molecular functioni

    1. 5-amino-6-(5-phosphoribosylamino)uracil reductase activity Source: InterPro
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. riboflavin biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Riboflavin biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciSSOL273057:GCH2-1962-MONOMER.
    UniPathwayiUPA00275.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase (EC:1.1.1.302)
    Short name:
    DAROPP reductase
    Short name:
    DARP reductase
    Alternative name(s):
    2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase
    2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase
    Short name:
    DARIPP synthase
    Gene namesi
    Ordered Locus Names:SSO2097
    ORF Names:C06025, C06_008
    OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
    Taxonomic identifieri273057 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001974: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2132132,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductasePRO_0000135946Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi273057.SSO2097.

    Structurei

    3D structure databases

    ProteinModelPortaliP95872.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HTP reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG1985.
    HOGENOMiHOG000225965.
    KOiK14654.
    OMAiKPYVISN.

    Family and domain databases

    Gene3Di3.40.430.10. 1 hit.
    InterProiIPR024072. DHFR-like_dom.
    IPR006401. Rib_reduct_arc.
    IPR011549. RibD_C.
    IPR002734. RibDG_C.
    [Graphical view]
    PfamiPF01872. RibD_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53597. SSF53597. 1 hit.
    TIGRFAMsiTIGR01508. rib_reduct_arch. 1 hit.
    TIGR00227. ribD_Cterm. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P95872-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVMKPYVIIF STVSIDGRLA TKTGYSELSC PYDKQRQHEI RSEVDAVMVG    50
    ANTVRVDNPS LTVKYGKNRR NPIRVVVTRS FNLDPSYKIF TTPPSTVIYT 100
    SNYESEKVEE FIRKGVIVRK FLHLDDLLED LYDNFNVRRL MVEGGGHLIW 150
    WFIKDNLYDE IRITISPRIF GNGVSFTQGE GFIGEDSPRL ELIDAKICEC 200
    GNEVHLTYKK YMT 213
    Length:213
    Mass (Da):24,561
    Last modified:May 1, 1997 - v1
    Checksum:iA741F6CADEF7631C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08256 Genomic DNA. Translation: CAA69508.1.
    AE006641 Genomic DNA. Translation: AAK42277.1.
    PIRiS74011.
    RefSeqiNP_343487.1. NC_002754.1.
    WP_010923770.1. NC_002754.1.

    Genome annotation databases

    EnsemblBacteriaiAAK42277; AAK42277; SSO2097.
    GeneIDi1453604.
    KEGGisso:SSO2097.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08256 Genomic DNA. Translation: CAA69508.1 .
    AE006641 Genomic DNA. Translation: AAK42277.1 .
    PIRi S74011.
    RefSeqi NP_343487.1. NC_002754.1.
    WP_010923770.1. NC_002754.1.

    3D structure databases

    ProteinModelPortali P95872.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273057.SSO2097.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK42277 ; AAK42277 ; SSO2097 .
    GeneIDi 1453604.
    KEGGi sso:SSO2097.

    Phylogenomic databases

    eggNOGi COG1985.
    HOGENOMi HOG000225965.
    KOi K14654.
    OMAi KPYVISN.

    Enzyme and pathway databases

    UniPathwayi UPA00275 .
    BioCyci SSOL273057:GCH2-1962-MONOMER.

    Family and domain databases

    Gene3Di 3.40.430.10. 1 hit.
    InterProi IPR024072. DHFR-like_dom.
    IPR006401. Rib_reduct_arc.
    IPR011549. RibD_C.
    IPR002734. RibDG_C.
    [Graphical view ]
    Pfami PF01872. RibD_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53597. SSF53597. 1 hit.
    TIGRFAMsi TIGR01508. rib_reduct_arch. 1 hit.
    TIGR00227. ribD_Cterm. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Organizational characteristics and information content of an archaeal genome: 156 kb of sequence from Sulfolobus solfataricus P2."
      Sensen C.W., Klenk H.-P., Singh R.K., Allard G., Chan C.C.-Y., Liu Q.Y., Penny S.L., Young F., Schenk M.E., Gaasterland T., Doolittle W.F., Ragan M.A., Charlebois R.L.
      Mol. Microbiol. 22:175-191(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

    Entry informationi

    Entry nameiRIB7_SULSO
    AccessioniPrimary (citable) accession number: P95872
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3