Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase

Gene

SSO2097

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.By similarity

Catalytic activityi

2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + NAD(P)+ = 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NAD(P)H.

Pathwayi: riboflavin biosynthesis

This protein is involved in the pathway riboflavin biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53NADPBy similarity1
Binding sitei57NADPBy similarity1
Binding sitei122NADP; via amide nitrogen and carbonyl oxygen1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi79 – 82NADPBy similarity4
Nucleotide bindingi145 – 148NADPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processRiboflavin biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00275

Names & Taxonomyi

Protein namesi
Recommended name:
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase (EC:1.1.1.302)
Short name:
DAROPP reductase
Short name:
DARP reductase
Alternative name(s):
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase
2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase
Short name:
DARIPP synthase
Gene namesi
Ordered Locus Names:SSO2097
ORF Names:C06025, C06_008
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001359461 – 2132,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductaseAdd BLAST213

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi273057.SSO2097

Structurei

3D structure databases

ProteinModelPortaliP95872
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HTP reductase family.Curated

Phylogenomic databases

eggNOGiarCOG01484 Archaea
COG1985 LUCA
HOGENOMiHOG000225965
InParanoidiP95872
KOiK14654
OMAiCECGQEV
OrthoDBiPOG093Z04B6

Family and domain databases

Gene3Di3.40.430.10, 1 hit
InterProiView protein in InterPro
IPR024072 DHFR-like_dom_sf
IPR006401 Rib_reduct_arc
IPR011549 RibD_C
IPR002734 RibDG_C
PfamiView protein in Pfam
PF01872 RibD_C, 1 hit
SUPFAMiSSF53597 SSF53597, 1 hit
TIGRFAMsiTIGR01508 rib_reduct_arch, 1 hit
TIGR00227 ribD_Cterm, 1 hit

Sequencei

Sequence statusi: Complete.

P95872-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMKPYVIIF STVSIDGRLA TKTGYSELSC PYDKQRQHEI RSEVDAVMVG
60 70 80 90 100
ANTVRVDNPS LTVKYGKNRR NPIRVVVTRS FNLDPSYKIF TTPPSTVIYT
110 120 130 140 150
SNYESEKVEE FIRKGVIVRK FLHLDDLLED LYDNFNVRRL MVEGGGHLIW
160 170 180 190 200
WFIKDNLYDE IRITISPRIF GNGVSFTQGE GFIGEDSPRL ELIDAKICEC
210
GNEVHLTYKK YMT
Length:213
Mass (Da):24,561
Last modified:May 1, 1997 - v1
Checksum:iA741F6CADEF7631C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08256 Genomic DNA Translation: CAA69508.1
AE006641 Genomic DNA Translation: AAK42277.1
PIRiS74011
RefSeqiWP_010923770.1, NZ_CP011056.1

Genome annotation databases

EnsemblBacteriaiAAK42277; AAK42277; SSO2097
GeneIDi25405284
KEGGisso:SSO2097
PATRICifig|273057.12.peg.2179

Entry informationi

Entry nameiRIB7_SULSO
AccessioniPrimary (citable) accession number: P95872
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health