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Protein

2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase

Gene

SSO2097

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.By similarity

Catalytic activityi

2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + NAD(P)+ = 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NAD(P)H.

Pathwayi: riboflavin biosynthesis

This protein is involved in the pathway riboflavin biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53NADPBy similarity1
Binding sitei57NADPBy similarity1
Binding sitei122NADP; via amide nitrogen and carbonyl oxygen1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi79 – 82NADPBy similarity4
Nucleotide bindingi145 – 148NADPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Riboflavin biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-1963-MONOMER.
UniPathwayiUPA00275.

Names & Taxonomyi

Protein namesi
Recommended name:
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase (EC:1.1.1.302)
Short name:
DAROPP reductase
Short name:
DARP reductase
Alternative name(s):
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase
2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase
Short name:
DARIPP synthase
Gene namesi
Ordered Locus Names:SSO2097
ORF Names:C06025, C06_008
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001359461 – 2132,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductaseAdd BLAST213

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi273057.SSO2097.

Structurei

3D structure databases

ProteinModelPortaliP95872.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HTP reductase family.Curated

Phylogenomic databases

eggNOGiarCOG01484. Archaea.
COG1985. LUCA.
HOGENOMiHOG000225965.
InParanoidiP95872.
KOiK14654.
OMAiKPYVISN.

Family and domain databases

Gene3Di3.40.430.10. 1 hit.
InterProiIPR024072. DHFR-like_dom.
IPR006401. Rib_reduct_arc.
IPR011549. RibD_C.
IPR002734. RibDG_C.
[Graphical view]
PfamiPF01872. RibD_C. 1 hit.
[Graphical view]
SUPFAMiSSF53597. SSF53597. 1 hit.
TIGRFAMsiTIGR01508. rib_reduct_arch. 1 hit.
TIGR00227. ribD_Cterm. 1 hit.

Sequencei

Sequence statusi: Complete.

P95872-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMKPYVIIF STVSIDGRLA TKTGYSELSC PYDKQRQHEI RSEVDAVMVG
60 70 80 90 100
ANTVRVDNPS LTVKYGKNRR NPIRVVVTRS FNLDPSYKIF TTPPSTVIYT
110 120 130 140 150
SNYESEKVEE FIRKGVIVRK FLHLDDLLED LYDNFNVRRL MVEGGGHLIW
160 170 180 190 200
WFIKDNLYDE IRITISPRIF GNGVSFTQGE GFIGEDSPRL ELIDAKICEC
210
GNEVHLTYKK YMT
Length:213
Mass (Da):24,561
Last modified:May 1, 1997 - v1
Checksum:iA741F6CADEF7631C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08256 Genomic DNA. Translation: CAA69508.1.
AE006641 Genomic DNA. Translation: AAK42277.1.
PIRiS74011.
RefSeqiWP_010923770.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK42277; AAK42277; SSO2097.
GeneIDi27428419.
KEGGisso:SSO2097.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08256 Genomic DNA. Translation: CAA69508.1.
AE006641 Genomic DNA. Translation: AAK42277.1.
PIRiS74011.
RefSeqiWP_010923770.1. NC_002754.1.

3D structure databases

ProteinModelPortaliP95872.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO2097.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK42277; AAK42277; SSO2097.
GeneIDi27428419.
KEGGisso:SSO2097.

Phylogenomic databases

eggNOGiarCOG01484. Archaea.
COG1985. LUCA.
HOGENOMiHOG000225965.
InParanoidiP95872.
KOiK14654.
OMAiKPYVISN.

Enzyme and pathway databases

UniPathwayiUPA00275.
BioCyciSSOL273057:GCH2-1963-MONOMER.

Family and domain databases

Gene3Di3.40.430.10. 1 hit.
InterProiIPR024072. DHFR-like_dom.
IPR006401. Rib_reduct_arc.
IPR011549. RibD_C.
IPR002734. RibDG_C.
[Graphical view]
PfamiPF01872. RibD_C. 1 hit.
[Graphical view]
SUPFAMiSSF53597. SSF53597. 1 hit.
TIGRFAMsiTIGR01508. rib_reduct_arch. 1 hit.
TIGR00227. ribD_Cterm. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRIB7_SULSO
AccessioniPrimary (citable) accession number: P95872
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.