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P95872

- RIB7_SULSO

UniProt

P95872 - RIB7_SULSO

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Protein

2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase

Gene

SSO2097

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.By similarity

Catalytic activityi

2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + NAD(P)+ = 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NAD(P)H.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531NADPBy similarity
Binding sitei57 – 571NADPBy similarity
Binding sitei122 – 1221NADP; via amide nitrogen and carbonyl oxygen

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi79 – 824NADPBy similarity
Nucleotide bindingi145 – 1484NADPBy similarity

GO - Molecular functioni

  1. 5-amino-6-(5-phosphoribosylamino)uracil reductase activity Source: InterPro
  2. NADP binding Source: InterPro

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Riboflavin biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-1962-MONOMER.
UniPathwayiUPA00275.

Names & Taxonomyi

Protein namesi
Recommended name:
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase (EC:1.1.1.302)
Short name:
DAROPP reductase
Short name:
DARP reductase
Alternative name(s):
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase
2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase
Short name:
DARIPP synthase
Gene namesi
Ordered Locus Names:SSO2097
ORF Names:C06025, C06_008
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001974: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2132132,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductasePRO_0000135946Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi273057.SSO2097.

Structurei

3D structure databases

ProteinModelPortaliP95872.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HTP reductase family.Curated

Phylogenomic databases

eggNOGiCOG1985.
HOGENOMiHOG000225965.
InParanoidiP95872.
KOiK14654.
OMAiKPYVISN.

Family and domain databases

Gene3Di3.40.430.10. 1 hit.
InterProiIPR024072. DHFR-like_dom.
IPR006401. Rib_reduct_arc.
IPR011549. RibD_C.
IPR002734. RibDG_C.
[Graphical view]
PfamiPF01872. RibD_C. 1 hit.
[Graphical view]
SUPFAMiSSF53597. SSF53597. 1 hit.
TIGRFAMsiTIGR01508. rib_reduct_arch. 1 hit.
TIGR00227. ribD_Cterm. 1 hit.

Sequencei

Sequence statusi: Complete.

P95872-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVMKPYVIIF STVSIDGRLA TKTGYSELSC PYDKQRQHEI RSEVDAVMVG
60 70 80 90 100
ANTVRVDNPS LTVKYGKNRR NPIRVVVTRS FNLDPSYKIF TTPPSTVIYT
110 120 130 140 150
SNYESEKVEE FIRKGVIVRK FLHLDDLLED LYDNFNVRRL MVEGGGHLIW
160 170 180 190 200
WFIKDNLYDE IRITISPRIF GNGVSFTQGE GFIGEDSPRL ELIDAKICEC
210
GNEVHLTYKK YMT
Length:213
Mass (Da):24,561
Last modified:May 1, 1997 - v1
Checksum:iA741F6CADEF7631C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08256 Genomic DNA. Translation: CAA69508.1.
AE006641 Genomic DNA. Translation: AAK42277.1.
PIRiS74011.
RefSeqiNP_343487.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK42277; AAK42277; SSO2097.
GeneIDi1453604.
KEGGisso:SSO2097.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08256 Genomic DNA. Translation: CAA69508.1 .
AE006641 Genomic DNA. Translation: AAK42277.1 .
PIRi S74011.
RefSeqi NP_343487.1. NC_002754.1.

3D structure databases

ProteinModelPortali P95872.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273057.SSO2097.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK42277 ; AAK42277 ; SSO2097 .
GeneIDi 1453604.
KEGGi sso:SSO2097.

Phylogenomic databases

eggNOGi COG1985.
HOGENOMi HOG000225965.
InParanoidi P95872.
KOi K14654.
OMAi KPYVISN.

Enzyme and pathway databases

UniPathwayi UPA00275 .
BioCyci SSOL273057:GCH2-1962-MONOMER.

Family and domain databases

Gene3Di 3.40.430.10. 1 hit.
InterProi IPR024072. DHFR-like_dom.
IPR006401. Rib_reduct_arc.
IPR011549. RibD_C.
IPR002734. RibDG_C.
[Graphical view ]
Pfami PF01872. RibD_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53597. SSF53597. 1 hit.
TIGRFAMsi TIGR01508. rib_reduct_arch. 1 hit.
TIGR00227. ribD_Cterm. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Organizational characteristics and information content of an archaeal genome: 156 kb of sequence from Sulfolobus solfataricus P2."
    Sensen C.W., Klenk H.-P., Singh R.K., Allard G., Chan C.C.-Y., Liu Q.Y., Penny S.L., Young F., Schenk M.E., Gaasterland T., Doolittle W.F., Ragan M.A., Charlebois R.L.
    Mol. Microbiol. 22:175-191(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiRIB7_SULSO
AccessioniPrimary (citable) accession number: P95872
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3