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P95872 (RIB7_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase

Short name=DAROPP reductase
Short name=DARP reductase
EC=1.1.1.302
Alternative name(s):
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase
2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase
Short name=DARIPP synthase
Gene names
Ordered Locus Names:SSO2097
ORF Names:C06025, C06_008
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [Reference proteome] [HAMAP]
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate By similarity.

Catalytic activity

2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + NAD(P)+ = 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NAD(P)H.

Pathway

Cofactor biosynthesis; riboflavin biosynthesis.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the HTP reductase family.

Ontologies

Keywords
   Biological processRiboflavin biosynthesis
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processriboflavin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_function5-amino-6-(5-phosphoribosylamino)uracil reductase activity

Inferred from electronic annotation. Source: InterPro

NADP binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2132132,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase
PRO_0000135946

Regions

Nucleotide binding79 – 824NADP By similarity
Nucleotide binding145 – 1484NADP By similarity

Sites

Binding site531NADP By similarity
Binding site571NADP By similarity
Binding site1221NADP; via amide nitrogen and carbonyl oxygen

Sequences

Sequence LengthMass (Da)Tools
P95872 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: A741F6CADEF7631C

FASTA21324,561
        10         20         30         40         50         60 
MVMKPYVIIF STVSIDGRLA TKTGYSELSC PYDKQRQHEI RSEVDAVMVG ANTVRVDNPS 

        70         80         90        100        110        120 
LTVKYGKNRR NPIRVVVTRS FNLDPSYKIF TTPPSTVIYT SNYESEKVEE FIRKGVIVRK 

       130        140        150        160        170        180 
FLHLDDLLED LYDNFNVRRL MVEGGGHLIW WFIKDNLYDE IRITISPRIF GNGVSFTQGE 

       190        200        210 
GFIGEDSPRL ELIDAKICEC GNEVHLTYKK YMT 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y08256 Genomic DNA. Translation: CAA69508.1.
AE006641 Genomic DNA. Translation: AAK42277.1.
PIRS74011.
RefSeqNP_343487.1. NC_002754.1.

3D structure databases

ProteinModelPortalP95872.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273057.SSO2097.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK42277; AAK42277; SSO2097.
GeneID1453604.
KEGGsso:SSO2097.

Phylogenomic databases

eggNOGCOG1985.
HOGENOMHOG000225965.
KOK14654.
OMAKPYVISN.
ProtClustDBPRK05625.

Enzyme and pathway databases

BioCycSSOL273057:GCH2-1962-MONOMER.
UniPathwayUPA00275.

Family and domain databases

Gene3D3.40.430.10. 1 hit.
InterProIPR024072. DHFR-like_dom.
IPR006401. Rib_reduct_arc.
IPR011549. RibD_C.
IPR002734. RibDG_C.
[Graphical view]
PfamPF01872. RibD_C. 1 hit.
[Graphical view]
SUPFAMSSF53597. SSF53597. 1 hit.
TIGRFAMsTIGR01508. rib_reduct_arch. 1 hit.
TIGR00227. ribD_Cterm. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRIB7_SULSO
AccessionPrimary (citable) accession number: P95872
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: October 16, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways