P95872 (RIB7_SULSO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative 5-amino-6-(5-phosphoribosylamino)uracil reductase
EC=1.1.1.193

Alternative name(s):
HTP reductase

Gene names

Ordered Locus Names:	SSO2097
ORF Names:	C06025, C06_008

Organism

Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

Taxonomic identifier

273057 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP+ = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH.
Pathway	Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.
Sequence similarities	Belongs to the HTP reductase family.

Ontologies

Keywords
Biological process	Riboflavin biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	riboflavin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	5-amino-6-(5-phosphoribosylamino)uracil reductase activity Inferred from electronic annotation. Source: EC NADP binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Putative 5-amino-6-(5-phosphoribosylamino)uracil reductase		PRO_0000135946

Sequences

	Sequence		Length	Mass (Da)
	P95872 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: A741F6CADEF7631C	FASTA	213	24,561
	10 20 30 40 50 60 MVMKPYVIIF STVSIDGRLA TKTGYSELSC PYDKQRQHEI RSEVDAVMVG ANTVRVDNPS 70 80 90 100 110 120 LTVKYGKNRR NPIRVVVTRS FNLDPSYKIF TTPPSTVIYT SNYESEKVEE FIRKGVIVRK 130 140 150 160 170 180 FLHLDDLLED LYDNFNVRRL MVEGGGHLIW WFIKDNLYDE IRITISPRIF GNGVSFTQGE 190 200 210 GFIGEDSPRL ELIDAKICEC GNEVHLTYKK YMT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Organizational characteristics and information content of an archaeal genome: 156 kb of sequence from Sulfolobus solfataricus P2." Sensen C.W., Klenk H.-P., Singh R.K., Allard G., Chan C.C.-Y., Liu Q.Y., Penny S.L., Young F., Schenk M.E., Gaasterland T., Doolittle W.F., Ragan M.A., Charlebois R.L. Mol. Microbiol. 22:175-191(1996) [PubMed: 8899719] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
[2]	"The complete genome of the crenarchaeon Sulfolobus solfataricus P2." She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. , Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T., Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J. Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed: 11427726] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y08256 Genomic DNA. Translation: CAA69508.1. AE006641 Genomic DNA. Translation: AAK42277.1.
PIR	S74011.
RefSeq	NP_343487.1. NC_002754.1.
3D structure databases
ProteinModelPortal	P95872.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1453604.
GenomeReviews	Gene locus SSO2097 in contig AE006641_GR.
KEGG	sso:SSO2097.
NMPDR	fig|273057.1.peg.1910.
Phylogenomic databases
HOGENOM	HBG668075.
OMA	DEIRLIH.
ProtClustDB	PRK05625.
Enzyme and pathway databases
BioCyc	SSOL273057:SSO2097-MONOMER.
Family and domain databases
InterPro	IPR024072. DHFR-like_dom. IPR006401. Rib_reduct_arc. IPR011549. RibD_C. IPR002734. RibDG_C. [Graphical view]
Gene3D	G3DSA:3.40.430.10. G3DSA:3.40.430.10. 1 hit.
KO	K14654.
Pfam	PF01872. RibD_C. 1 hit. [Graphical view]
SUPFAM	SSF53597. SSF53597. 1 hit.
TIGRFAMs	TIGR01508. Rib_reduct_arch. 1 hit. TIGR00227. RibD_Cterm. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RIB7_SULSO

Accession

Primary (citable) accession number: P95872

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 1997
Last modified:	December 14, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program