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Protein

DNA protection during starvation protein

Gene

dps

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity). In vitro, it efficiently oxidizes Fe2+ in the presence of hydrogen peroxide and stores it as a mineral core.By similarity1 Publication

Catalytic activityi

2 Fe2+ + H2O2 + 2 H+ = 2 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi37IronSequence analysis1
Metal bindingi73IronSequence analysis1
Metal bindingi124IronSequence analysis1
Metal bindingi156IronSequence analysis1
Metal bindingi159IronSequence analysis1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA protection during starvation protein (EC:1.16.-.-)
Gene namesi
Name:dps
Ordered Locus Names:SSO2079
ORF Names:C06008
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002533381 – 188DNA protection during starvation proteinAdd BLAST188

Expressioni

Inductioni

Up-regulated in cultures grown in iron-depleted media and upon hydrogen peroxide stress, but is not induced by other stress.

Interactioni

Subunit structurei

Homododecamer. The 12 identical subunits form a hollow sphere into which the mineral iron core of up to 300 Fe3+ can be deposited.1 Publication

Protein-protein interaction databases

STRINGi273057.SSO2079.

Structurei

Secondary structure

1188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 17Combined sources7
Turni18 – 20Combined sources3
Helixi23 – 49Combined sources27
Helixi53 – 56Combined sources4
Helixi57 – 59Combined sources3
Helixi60 – 83Combined sources24
Helixi92 – 98Combined sources7
Turni108 – 111Combined sources4
Helixi113 – 138Combined sources26
Turni139 – 141Combined sources3
Helixi143 – 167Combined sources25

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CLBX-ray2.40A/B/C/D/M/N/O/P1-188[»]
ProteinModelPortaliP95855.
SMRiP95855.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP95855.

Family & Domainsi

Sequence similaritiesi

Belongs to the Dps family.Curated

Phylogenomic databases

eggNOGiarCOG01093. Archaea.
COG2406. LUCA.
HOGENOMiHOG000106499.
InParanoidiP95855.
OMAiTTFYYYT.

Family and domain databases

CDDicd01052. DPSL. 1 hit.
Gene3Di1.20.1260.10. 1 hit.
InterProiIPR014490. Dps-like.
IPR033921. DPSL_diiron-bd_dom.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
PIRSFiPIRSF018063. Ferrtn_UCP018063. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.

Sequencei

Sequence statusi: Complete.

P95855-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEKPQEPKV VGVEILEKSG LDIKKLVDKL VKATAAEFTT YYYYTILRMH
60 70 80 90 100
LTGMEGEGLK EIAEDARLED RLHFELMTQR IYELGGGLPR DIRQLADISA
110 120 130 140 150
CSDAYLPENW KDPKEILKVL LEAEQCAIRT WKEVCDMTYG KDPRTYDLAQ
160 170 180
RILQEEIEHE AWFLELLYGR PSGHFRRSSP GNAPYSKK
Length:188
Mass (Da):21,770
Last modified:May 1, 1997 - v1
Checksum:i617F4CA5A2316F6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08256 Genomic DNA. Translation: CAA69491.1.
AE006641 Genomic DNA. Translation: AAK42260.1.
AB047031 Genomic DNA. Translation: BAB17764.1.
PIRiS73096.
RefSeqiWP_009989805.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK42260; AAK42260; SSO2079.
GeneIDi27428403.
KEGGisso:SSO2079.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08256 Genomic DNA. Translation: CAA69491.1.
AE006641 Genomic DNA. Translation: AAK42260.1.
AB047031 Genomic DNA. Translation: BAB17764.1.
PIRiS73096.
RefSeqiWP_009989805.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CLBX-ray2.40A/B/C/D/M/N/O/P1-188[»]
ProteinModelPortaliP95855.
SMRiP95855.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO2079.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK42260; AAK42260; SSO2079.
GeneIDi27428403.
KEGGisso:SSO2079.

Phylogenomic databases

eggNOGiarCOG01093. Archaea.
COG2406. LUCA.
HOGENOMiHOG000106499.
InParanoidiP95855.
OMAiTTFYYYT.

Miscellaneous databases

EvolutionaryTraceiP95855.

Family and domain databases

CDDicd01052. DPSL. 1 hit.
Gene3Di1.20.1260.10. 1 hit.
InterProiIPR014490. Dps-like.
IPR033921. DPSL_diiron-bd_dom.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
PIRSFiPIRSF018063. Ferrtn_UCP018063. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDPS_SULSO
AccessioniPrimary (citable) accession number: P95855
Secondary accession number(s): Q9HHC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.