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Protein

DNA protection during starvation protein

Gene

dps

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity). In vitro, it efficiently oxidizes Fe2+ in the presence of hydrogen peroxide and stores it as a mineral core.By similarity1 Publication

Catalytic activityi

2 Fe2+ + H2O2 + 2 H+ = 2 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi37 – 371IronSequence analysis
Metal bindingi73 – 731IronSequence analysis
Metal bindingi124 – 1241IronSequence analysis
Metal bindingi156 – 1561IronSequence analysis
Metal bindingi159 – 1591IronSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-1945-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA protection during starvation protein (EC:1.16.-.-)
Gene namesi
Name:dps
Ordered Locus Names:SSO2079
ORF Names:C06008
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188DNA protection during starvation proteinPRO_0000253338Add
BLAST

Expressioni

Inductioni

Up-regulated in cultures grown in iron-depleted media and upon hydrogen peroxide stress, but is not induced by other stress.

Interactioni

Subunit structurei

Homododecamer. The 12 identical subunits form a hollow sphere into which the mineral iron core of up to 300 Fe3+ can be deposited.1 Publication

Protein-protein interaction databases

STRINGi273057.SSO2079.

Structurei

Secondary structure

1
188
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 177Combined sources
Turni18 – 203Combined sources
Helixi23 – 4927Combined sources
Helixi53 – 564Combined sources
Helixi57 – 593Combined sources
Helixi60 – 8324Combined sources
Helixi92 – 987Combined sources
Turni108 – 1114Combined sources
Helixi113 – 13826Combined sources
Turni139 – 1413Combined sources
Helixi143 – 16725Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CLBX-ray2.40A/B/C/D/M/N/O/P1-188[»]
ProteinModelPortaliP95855.
SMRiP95855. Positions 6-174.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP95855.

Family & Domainsi

Sequence similaritiesi

Belongs to the Dps family.Curated

Phylogenomic databases

eggNOGiarCOG01093. Archaea.
COG2406. LUCA.
HOGENOMiHOG000106499.
InParanoidiP95855.
OMAiTTFYYYT.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
IPR014490. UCP018063_ferrtn.
[Graphical view]
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
PIRSFiPIRSF018063. Ferrtn_UCP018063. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.

Sequencei

Sequence statusi: Complete.

P95855-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEKPQEPKV VGVEILEKSG LDIKKLVDKL VKATAAEFTT YYYYTILRMH
60 70 80 90 100
LTGMEGEGLK EIAEDARLED RLHFELMTQR IYELGGGLPR DIRQLADISA
110 120 130 140 150
CSDAYLPENW KDPKEILKVL LEAEQCAIRT WKEVCDMTYG KDPRTYDLAQ
160 170 180
RILQEEIEHE AWFLELLYGR PSGHFRRSSP GNAPYSKK
Length:188
Mass (Da):21,770
Last modified:May 1, 1997 - v1
Checksum:i617F4CA5A2316F6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08256 Genomic DNA. Translation: CAA69491.1.
AE006641 Genomic DNA. Translation: AAK42260.1.
AB047031 Genomic DNA. Translation: BAB17764.1.
PIRiS73096.
RefSeqiWP_009989805.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK42260; AAK42260; SSO2079.
GeneIDi25405268.
KEGGisso:SSO2079.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08256 Genomic DNA. Translation: CAA69491.1.
AE006641 Genomic DNA. Translation: AAK42260.1.
AB047031 Genomic DNA. Translation: BAB17764.1.
PIRiS73096.
RefSeqiWP_009989805.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CLBX-ray2.40A/B/C/D/M/N/O/P1-188[»]
ProteinModelPortaliP95855.
SMRiP95855. Positions 6-174.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO2079.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK42260; AAK42260; SSO2079.
GeneIDi25405268.
KEGGisso:SSO2079.

Phylogenomic databases

eggNOGiarCOG01093. Archaea.
COG2406. LUCA.
HOGENOMiHOG000106499.
InParanoidiP95855.
OMAiTTFYYYT.

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-1945-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP95855.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
IPR014490. UCP018063_ferrtn.
[Graphical view]
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
PIRSFiPIRSF018063. Ferrtn_UCP018063. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Organizational characteristics and information content of an archaeal genome: 156 kb of sequence from Sulfolobus solfataricus P2."
    Sensen C.W., Klenk H.-P., Singh R.K., Allard G., Chan C.C.-Y., Liu Q.Y., Penny S.L., Young F., Schenk M.E., Gaasterland T., Doolittle W.F., Ragan M.A., Charlebois R.L.
    Mol. Microbiol. 22:175-191(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
  3. "Redox-dependent structural changes in archaeal and bacterial Rieske-type [2Fe-2S] clusters."
    Cosper N.J., Eby D.M., Kounosu A., Kurosawa N., Neidle E.L., Kurtz D.M. Jr., Iwasaki T., Scott R.A.
    Protein Sci. 11:2969-2973(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 151-188.
    Strain: ATCC 35091 / DSM 1616 / IFO 15331 / JCM 8930 / P1.
  4. "An archaeal antioxidant: characterization of a Dps-like protein from Sulfolobus solfataricus."
    Wiedenheft B., Mosolf J., Willits D., Yeager M., Dryden K.A., Young M., Douglas T.
    Proc. Natl. Acad. Sci. U.S.A. 102:10551-10556(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN IRON OXIDATION, FUNCTION IN MINERALIZATION, SUBUNIT.
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiDPS_SULSO
AccessioniPrimary (citable) accession number: P95855
Secondary accession number(s): Q9HHC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: May 1, 1997
Last modified: November 11, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.