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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts as a chaperone.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaK
Alternative name(s):
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene namesi
Name:dnaK
Ordered Locus Names:SP_0517
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000785531 – 607Chaperone protein DnaKAdd BLAST607

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173Phosphothreonine; by autocatalysisBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP95829.

Expressioni

Inductioni

By stress conditions e.g. heat shock (By similarity).By similarity

Interactioni

Protein-protein interaction databases

STRINGi170187.SpneT_02001162.

Structurei

3D structure databases

ProteinModelPortaliP95829.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228137.
KOiK04043.
OMAiEKMAPPQ.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P95829-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIIGIDLG TTNSAVAVLE GTESKIIANP EGNRTTPSVV SFKNGEIIVG
60 70 80 90 100
DAAKRQAVTN PDTVISIKSK MGTSEKVSAN GKEYTPQEIS AMILQYLKGY
110 120 130 140 150
AEDYLGEKVT KAVITVPAYF NDAQRQATKD AGKIAGLEVE RIVNEPTAAA
160 170 180 190 200
LAYGLDKTDK EEKILVFDLG GGTFDVSILE LGDGVFDVLS TAGDNKLGGD
210 220 230 240 250
DFDQKIIDHL VAEFKKENGI DLSTDKMAMQ RLKDAAEKAK KDLSGVTSTQ
260 270 280 290 300
ISLPFITAGE AGPLHLEMTL TRAKFDDLTR DLVERTKVPV RQALSDAGLS
310 320 330 340 350
LSEIDEVILV GGSTRIPAVV EAVKAETGKE PNKSVNPDEV VAMGAAIQGG
360 370 380 390 400
VITGDVKDVV LLDVTPLSLG IETMGGVFTK LIDRNTTIPT SKSQVFSTAA
410 420 430 440 450
DNQPAVDIHV LQGERPMAAD NKTLGRFQLT DIPAAPRGIP QIEVTFDIDK
460 470 480 490 500
NGIVSVKAKD LGTQKEQTIV IQSNSGLTDE EIDRMMKDAE ANAEADKKRK
510 520 530 540 550
EEVDLRNEVD QAIFATEKTI KETEGKGFDA ERDAAQAALD DLKKAQEDNN
560 570 580 590 600
LDDMKTKLEA LNEKAQGLAV KLYEQAAAAQ QAQEGAEGAQ ATGNAGDDVV

DGEFTEK
Length:607
Mass (Da):64,842
Last modified:September 26, 2001 - v2
Checksum:i11D626F1837D0760
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti493A → P in AAC15892 (PubMed:9570114).Curated1
Sequence conflicti495A → S in AAB39221 (Ref. 1) Curated1
Sequence conflicti530A → P in AAC15892 (PubMed:9570114).Curated1
Sequence conflicti556T → A (Ref. 1) Curated1
Sequence conflicti556T → A (PubMed:9570114).Curated1
Sequence conflicti601 – 602DG → E in AAC15892 (PubMed:9570114).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72720 Genomic DNA. Translation: AAB39221.1.
U84387 Genomic DNA. Translation: AAC15892.1.
AE005672 Genomic DNA. Translation: AAK74675.1.
PIRiB95060.
RefSeqiWP_000034665.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK74675; AAK74675; SP_0517.
KEGGispn:SP_0517.
PATRICi19705385. VBIStrPne105772_0538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72720 Genomic DNA. Translation: AAB39221.1.
U84387 Genomic DNA. Translation: AAC15892.1.
AE005672 Genomic DNA. Translation: AAK74675.1.
PIRiB95060.
RefSeqiWP_000034665.1. NZ_AKVY01000001.1.

3D structure databases

ProteinModelPortaliP95829.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi170187.SpneT_02001162.

Proteomic databases

PRIDEiP95829.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK74675; AAK74675; SP_0517.
KEGGispn:SP_0517.
PATRICi19705385. VBIStrPne105772_0538.

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228137.
KOiK04043.
OMAiEKMAPPQ.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAK_STRPN
AccessioniPrimary (citable) accession number: P95829
Secondary accession number(s): O66035
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 26, 2001
Last modified: November 2, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.