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Protein

Probable manganese-dependent inorganic pyrophosphatase

Gene

ppaC

Organism
Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.

Cofactori

Mn2+Note: Binds 2 manganese ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Manganese 11
Metal bindingi13Manganese 11
Metal bindingi15Manganese 21
Metal bindingi77Manganese 11
Metal bindingi77Manganese 21
Metal bindingi99Manganese 21
Metal bindingi151Manganese 21

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BRENDAi3.6.1.1. 5934.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable manganese-dependent inorganic pyrophosphatase (EC:3.6.1.1)
Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name:
PPase
Gene namesi
Name:ppaC
Ordered Locus Names:SGO_1648
OrganismiStreptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
Taxonomic identifieri467705 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001131 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001585891 – 311Probable manganese-dependent inorganic pyrophosphataseAdd BLAST311

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi467705.SGO_1648.

Structurei

Secondary structure

1311
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 7Combined sources4
Helixi14 – 31Combined sources18
Beta strandi35 – 37Combined sources3
Beta strandi39 – 41Combined sources3
Helixi45 – 54Combined sources10
Helixi66 – 68Combined sources3
Beta strandi71 – 77Combined sources7
Helixi81 – 83Combined sources3
Helixi88 – 90Combined sources3
Beta strandi91 – 98Combined sources8
Beta strandi112 – 115Combined sources4
Beta strandi117 – 119Combined sources3
Helixi121 – 131Combined sources11
Helixi138 – 152Combined sources15
Turni153 – 156Combined sources4
Helixi162 – 175Combined sources14
Helixi179 – 188Combined sources10
Helixi198 – 201Combined sources4
Beta strandi204 – 211Combined sources8
Beta strandi214 – 224Combined sources11
Helixi226 – 230Combined sources5
Helixi233 – 247Combined sources15
Beta strandi250 – 258Combined sources9
Turni259 – 262Combined sources4
Beta strandi263 – 271Combined sources9
Helixi273 – 280Combined sources8
Beta strandi288 – 292Combined sources5
Helixi297 – 300Combined sources4
Helixi302 – 310Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K20X-ray1.50A/B2-311[»]
1WPPX-ray2.05A/B1-311[»]
ProteinModelPortaliP95765.
SMRiP95765.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP95765.

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase class C family.Curated

Phylogenomic databases

eggNOGiENOG4105E2M. Bacteria.
COG1227. LUCA.
HOGENOMiHOG000223999.
KOiK15986.
OMAiMLCAILS.
OrthoDBiPOG091H00ML.

Family and domain databases

HAMAPiMF_00207. PPase_C. 1 hit.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P95765-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKILVFGHQ NPDSDAIGSS YAFAYLAREA YGLDTEAVAL GEPNEETAFV
60 70 80 90 100
LDYFGVAAPR VITSAKAEGA EQVILTDHNE FQQSVADIAE VEVYGVVDHH
110 120 130 140 150
RVANFETANP LYMRLEPVGS ASSIVYRMFK EHSVAVSKEI AGLMLSGLIS
160 170 180 190 200
DTLLLKSPTT HPTDKAIAPE LAELAGVNLE EYGLAMLKAG TNLASKSAEE
210 220 230 240 250
LIDIDAKTFE LNGNNVRVAQ VNTVDIAEVL ERQAEIEAAI EKAIADNGYS
260 270 280 290 300
DFVLMITDII NSNSEILAIG SNMDKVEAAF NFVLENNHAF LAGAVSRKKQ
310
VVPQLTESFN A
Length:311
Mass (Da):33,541
Last modified:May 1, 1997 - v1
Checksum:i610A704B681E2889
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57759 Genomic DNA. Translation: AAB39104.1.
CP000725 Genomic DNA. Translation: ABV09962.1.
RefSeqiWP_012130706.1. NC_009785.1.

Genome annotation databases

EnsemblBacteriaiABV09962; ABV09962; SGO_1648.
GeneIDi25051201.
KEGGisgo:SGO_1648.
PATRICi19661242. VBIStrGor124371_1622.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57759 Genomic DNA. Translation: AAB39104.1.
CP000725 Genomic DNA. Translation: ABV09962.1.
RefSeqiWP_012130706.1. NC_009785.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K20X-ray1.50A/B2-311[»]
1WPPX-ray2.05A/B1-311[»]
ProteinModelPortaliP95765.
SMRiP95765.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi467705.SGO_1648.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV09962; ABV09962; SGO_1648.
GeneIDi25051201.
KEGGisgo:SGO_1648.
PATRICi19661242. VBIStrGor124371_1622.

Phylogenomic databases

eggNOGiENOG4105E2M. Bacteria.
COG1227. LUCA.
HOGENOMiHOG000223999.
KOiK15986.
OMAiMLCAILS.
OrthoDBiPOG091H00ML.

Enzyme and pathway databases

BRENDAi3.6.1.1. 5934.

Miscellaneous databases

EvolutionaryTraceiP95765.

Family and domain databases

HAMAPiMF_00207. PPase_C. 1 hit.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPAC_STRGC
AccessioniPrimary (citable) accession number: P95765
Secondary accession number(s): A8AYR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.