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Protein

GTPase Obg

Gene

obg

Organism
Streptomyces griseus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Overexpression suppresses sporulation although cell growth rate was not reduced. Impaired differentiation was eliminated by addition of decoyinine, an inhibitor of GMP synthesis. Overexpression has no effect on streptomycin production.
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi173MagnesiumUniRule annotation1
Metal bindingi193MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi166 – 173GTPUniRule annotation8
Nucleotide bindingi191 – 195GTPUniRule annotation5
Nucleotide bindingi212 – 215GTPUniRule annotation4
Nucleotide bindingi282 – 285GTPUniRule annotation4
Nucleotide bindingi311 – 313GTPUniRule annotation3

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase ObgUniRule annotation (EC:3.6.5.-UniRule annotation)
Alternative name(s):
GTP-binding protein ObgUniRule annotation
Gene namesi
Name:obgUniRule annotation
OrganismiStreptomyces griseus
Taxonomic identifieri1911 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003863241 – 478GTPase ObgAdd BLAST478

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP95758.
SMRiP95758.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini160 – 330OBG-type GUniRule annotationAdd BLAST171

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9R. Bacteria.
COG0536. LUCA.

Family and domain databases

CDDicd01898. Obg. 1 hit.
Gene3Di2.70.210.12. 1 hit.
HAMAPiMF_01454. GTPase_Obg. 1 hit.
InterProiView protein in InterPro
IPR031167. G_OBG.
IPR014100. GTP-bd_Obg/CgtA.
IPR015349. GTP-bd_prot_GTP1/OBG_C.
IPR006074. GTP1-OBG_CS.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF09269. DUF1967. 1 hit.
PF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF102741. SSF102741. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF82051. SSF82051. 1 hit.
TIGRFAMsiTIGR02729. Obg_CgtA. 1 hit.
TIGR03595. Obg_CgtA_exten. 1 hit.
PROSITEiView protein in PROSITE
PS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.

Sequencei

Sequence statusi: Complete.

P95758-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTFVDRVEL HAAAGNGGHG CASVHREKFK PLGGPDGGNG GRGGDVILVV
60 70 80 90 100
EQSVTTLLDY HHSPHRKATN GQPGAGDNRS GKDGQDLVLP VPDGTVVLDK
110 120 130 140 150
AGNVLADLVG QGTTFVAGQG GRGGLGNAAL ASARRKAPGF ALLGEPGESR
160 170 180 190 200
DIVLELKTVA DVALVGYPSA GKSSLISVLS AAKPKIADYP FTTLVPNLGV
210 220 230 240 250
VTAGSTVYTI ADVPGLIPGA SQGKGLGLEF LRHVERCSVL VHVLDTATLE
260 270 280 290 300
SDRDPVSDLD MIEEELRLYG GLENRPRIVA LNKVDIPDGQ DLADMIRPDL
310 320 330 340 350
EARGYRVFEV SAIAHKGLKE LSFALAGIIA EARATKPKEE ATRIVIRPRA
360 370 380 390 400
VDDAGFTVTL EDDGIYRVRG EKPERWVRQT DFNNDEAVGY LADRLNRLGV
410 420 430 440 450
EDSLMKAGAR AGDGVAIGPE ENAVVFDWEP TVTAGAEMLG RRGEDHRLEE
460 470
PRPAAQRRRE RDAERDDAEK EYDEFDPF
Length:478
Mass (Da):51,024
Last modified:May 1, 1997 - v1
Checksum:i2E30119EA1B3E98D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87916 Genomic DNA. Translation: BAA13501.1.
RefSeqiWP_003969206.1. NZ_MDDK01000023.1.

Genome annotation databases

GeneIDi6211583.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiOBG_STRGR
AccessioniPrimary (citable) accession number: P95758
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: May 1, 1997
Last modified: July 5, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families