Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTPase Obg

Gene

obg

Organism
Streptomyces griseus
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Overexpression suppresses sporulation although cell growth rate was not reduced. Impaired differentiation was eliminated by addition of decoyinine, an inhibitor of GMP synthesis. Overexpression has no effect on streptomycin production.
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi173MagnesiumUniRule annotation1
Metal bindingi193MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi166 – 173GTPUniRule annotation8
Nucleotide bindingi191 – 195GTPUniRule annotation5
Nucleotide bindingi212 – 215GTPUniRule annotation4
Nucleotide bindingi282 – 285GTPUniRule annotation4
Nucleotide bindingi311 – 313GTPUniRule annotation3

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase ObgUniRule annotation (EC:3.6.5.-UniRule annotation)
Alternative name(s):
GTP-binding protein ObgUniRule annotation
Gene namesi
Name:obgUniRule annotation
OrganismiStreptomyces griseus
Taxonomic identifieri1911 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003863241 – 478GTPase ObgAdd BLAST478

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP95758
SMRiP95758
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini160 – 330OBG-type GUniRule annotationAdd BLAST171

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9R Bacteria
COG0536 LUCA

Family and domain databases

CDDicd01898 Obg, 1 hit
Gene3Di2.40.240.60, 1 hit
2.70.210.12, 1 hit
HAMAPiMF_01454 GTPase_Obg, 1 hit
InterProiView protein in InterPro
IPR031167 G_OBG
IPR014100 GTP-bd_Obg/CgtA
IPR015349 GTP-bd_prot_GTP1/OBG_C
IPR036346 GTP-bd_prot_GTP1/OBG_C_sf
IPR006074 GTP1-OBG_CS
IPR006169 GTP1_OBG_dom
IPR036726 GTP1_OBG_dom_sf
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF09269 DUF1967, 1 hit
PF01018 GTP1_OBG, 1 hit
PF01926 MMR_HSR1, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF102741 SSF102741, 1 hit
SSF52540 SSF52540, 1 hit
SSF82051 SSF82051, 1 hit
TIGRFAMsiTIGR02729 Obg_CgtA, 1 hit
TIGR03595 Obg_CgtA_exten, 1 hit
PROSITEiView protein in PROSITE
PS51710 G_OBG, 1 hit
PS00905 GTP1_OBG, 1 hit

Sequencei

Sequence statusi: Complete.

P95758-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTFVDRVEL HAAAGNGGHG CASVHREKFK PLGGPDGGNG GRGGDVILVV
60 70 80 90 100
EQSVTTLLDY HHSPHRKATN GQPGAGDNRS GKDGQDLVLP VPDGTVVLDK
110 120 130 140 150
AGNVLADLVG QGTTFVAGQG GRGGLGNAAL ASARRKAPGF ALLGEPGESR
160 170 180 190 200
DIVLELKTVA DVALVGYPSA GKSSLISVLS AAKPKIADYP FTTLVPNLGV
210 220 230 240 250
VTAGSTVYTI ADVPGLIPGA SQGKGLGLEF LRHVERCSVL VHVLDTATLE
260 270 280 290 300
SDRDPVSDLD MIEEELRLYG GLENRPRIVA LNKVDIPDGQ DLADMIRPDL
310 320 330 340 350
EARGYRVFEV SAIAHKGLKE LSFALAGIIA EARATKPKEE ATRIVIRPRA
360 370 380 390 400
VDDAGFTVTL EDDGIYRVRG EKPERWVRQT DFNNDEAVGY LADRLNRLGV
410 420 430 440 450
EDSLMKAGAR AGDGVAIGPE ENAVVFDWEP TVTAGAEMLG RRGEDHRLEE
460 470
PRPAAQRRRE RDAERDDAEK EYDEFDPF
Length:478
Mass (Da):51,024
Last modified:May 1, 1997 - v1
Checksum:i2E30119EA1B3E98D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87916 Genomic DNA Translation: BAA13501.1
RefSeqiWP_003969206.1, NZ_MDDK01000023.1

Genome annotation databases

GeneIDi6211583

Similar proteinsi

Entry informationi

Entry nameiOBG_STRGR
AccessioniPrimary (citable) accession number: P95758
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: May 1, 1997
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health