Reviewed, UniProtKB/Swiss-Prot P95721 (ARGR_STRCL)

Names and origin

Protein names

Recommended name:
    Arginine repressor

Gene names

Name:

argR

Organism

Streptomyces clavuligerus

Taxonomic identifier

1901 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Regulates arginine biosynthesis genes. HAMAP MF_00173
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis. [regulation] HAMAP MF_00173
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the argR family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis Transcription Transcription regulation
Cellular component	Cytoplasm
Ligand	DNA-binding
Molecular function	Repressor
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: HAMAP transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transcription factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 178	178	Arginine repressor HAMAP MF_00173		PRO_0000205123

Sequences

	Sequence		Length	Mass (Da)
	P95721-1 [UniParc]. Last modified August 14, 2001. Version 2. Checksum: 864CA16B3D0F187D	FASTA	178	18,908
	10 20 30 40 50 60 MTEAHATDAG GPAVPQTRMA RHRRIVDILN RQPVRSQSQL AKLLADNGLS VTQATLSRDL 70 80 90 100 110 120 DELGAVKIRN TMARLIYAVP ARGVPHSAGA LGESAKEERM RRLAGELLIS AEASANLVVL 130 140 150 160 170 RTPPGAAQFL ASAIDQAELH DILGTIAGDD TLMLISRSPT GGQALADHLL RLAQNDRA

References

[1]	"Arginine boxes and the argR gene in Streptomyces clavuligerus: evidence for a clear regulation of the arginine pathway." Rodriguez-Garcia A., Ludovice M., Martin J.F., Liras P. Mol. Microbiol. 25:219-228(1997) [PubMed: 9282734] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 27064 / DSM 738 / IFO 13307 / JCM 4710 / NRRL 3585.
[2]	"Characterization and expression of the arginine biosynthesis gene cluster of Streptomyces clavuligerus." Rodriguez-Garcia A., de la Fuente A., Perez-Redondo R., Martin J.F., Liras P. J. Mol. Microbiol. Biotechnol. 2:543-550(2000) [PubMed: 11075930] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 27064 / DSM 738 / IFO 13307 / JCM 4710 / NRRL 3585.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z49111 Genomic DNA. Translation: CAB82483.1.
PIR	PC4127.
3D structure databases
HSSP	HSSP built from PDB template 1B4B based on UniProtKB O31408.
ModBase	Search...
Family and domain databases
HAMAP	MF_00173. [Tree]
InterPro	IPR001669. Arg_repress. IPR011991. Wing_hlx_DNA_bd. [Graphical view]
Gene3D	G3DSA:3.30.1360.40. Arg_repress. 1 hit. G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
Pfam	PF01316. Arg_repressor. 1 hit. PF02863. Arg_repressor_C. 1 hit. [Graphical view]
PRINTS	PR01467. ARGREPRESSOR.
ProDom	PD007402. Arg_repress. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01529. argR_whole. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGR_STRCL

Accession

Primary (citable) accession number: P95721
Secondary accession number(s): Q9LCS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	August 14, 2001
Last modified:	June 16, 2009
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)