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Protein

Catalase A

Gene

katA

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei55 – 551By similarity
Active sitei127 – 1271By similarity
Metal bindingi337 – 3371Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-783-MONOMER.

Protein family/group databases

PeroxiBasei4297. SmeKat01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase A (EC:1.11.1.6)
Gene namesi
Name:katA
Ordered Locus Names:R00764
ORF Names:SMc00819
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Catalase APRO_0000084996Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc00819.

Structurei

3D structure databases

ProteinModelPortaliP95631.
SMRiP95631. Positions 6-480.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

eggNOGiENOG4105CH6. Bacteria.
COG0753. LUCA.
HOGENOMiHOG000087852.
KOiK03781.
OMAiPVAHNQN.
OrthoDBiEOG6P5Z9F.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P95631-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDRPTITTT AGAPVPDNQN SLTAGPRGGI MLQDYQLIEK LAHQNRERIP
60 70 80 90 100
ERVVHAKGWG AFGSLKITGD ISQYTRAKCL QPGAETPMLA RFSTVAGEQG
110 120 130 140 150
AADHERDVRG FALKFYTDEG NWDLVGNNTP VFFIRDPYKF PDFIHTQKRH
160 170 180 190 200
PKTNLRSATA MWDYWSLSPE SLHQVTILMS DRGLPQTPMH MNGYGSHTYS
210 220 230 240 250
FWNDAGERYW VKFHFKTQQG HKFFTNEEGE AVIGKTREGY QESLFYAIEN
260 270 280 290 300
GEFPRWTVQV QIMPELDVEK TPYNPFDLTK VWPHADYPPV EIGVLELNRN
310 320 330 340 350
PENYFAEIEN AAFSPSNIVP GIGFSPDKVL QARIFSYADA HRYRLGTHYE
360 370 380 390 400
HIPVNQPRCP VHHYHRDGQM NTYGGIRTGN PDAYYEPNSF NGPAEQPLAK
410 420 430 440 450
EPPLRIDGDM SRYDHRVGND DYVQVRALFG LFDEGQKSRL FSNIAAAMGG
460 470 480 490
VPGEIIERQL IHFARVHPEY EAGVRQALKT AHGYEADTIS TAAE
Length:494
Mass (Da):56,009
Last modified:May 30, 2000 - v2
Checksum:i39FA86606D2D83D7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 1919MTDRP…VPDNQ → MPPPLPERRHLICACVGTYC GCGSNPPSGSSPFVPASFFV PAEGTAEPRCGGVSSPRSRA GFSPRIRALISSPVSVSYSS KPSARAT (PubMed:8955300).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59271 Genomic DNA. Translation: AAC44649.1.
AL591688 Genomic DNA. Translation: CAC45336.1.
RefSeqiNP_384870.1. NC_003047.1.
WP_010968798.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC45336; CAC45336; SMc00819.
GeneIDi1232405.
KEGGisme:SMc00819.
PATRICi23630769. VBISinMel96828_2148.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59271 Genomic DNA. Translation: AAC44649.1.
AL591688 Genomic DNA. Translation: CAC45336.1.
RefSeqiNP_384870.1. NC_003047.1.
WP_010968798.1. NC_003047.1.

3D structure databases

ProteinModelPortaliP95631.
SMRiP95631. Positions 6-480.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266834.SMc00819.

Protein family/group databases

PeroxiBasei4297. SmeKat01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC45336; CAC45336; SMc00819.
GeneIDi1232405.
KEGGisme:SMc00819.
PATRICi23630769. VBISinMel96828_2148.

Phylogenomic databases

eggNOGiENOG4105CH6. Bacteria.
COG0753. LUCA.
HOGENOMiHOG000087852.
KOiK03781.
OMAiPVAHNQN.
OrthoDBiEOG6P5Z9F.

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-783-MONOMER.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the katA gene of Rhizobium meliloti encoding a hydrogen peroxide-inducible catalase."
    Herouart D., Sigaud S., Moreau S., Frendo P., Touati D., Puppo A.
    J. Bacteriol. 178:6802-6809(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: RCR2011 / SU47.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiCATA_RHIME
AccessioniPrimary (citable) accession number: P95631
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 11, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.