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Protein

Catechol 1,2-dioxygenase

Gene

catA

Organism
Rhodococcus opacus (Nocardia opaca)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Catechol + O2 = cis,cis-muconate.

Cofactori

Fe3+Note: Binds 1 Fe3+ ion per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi152 – 1521IronBy similarity
Metal bindingi186 – 1861IronBy similarity
Metal bindingi210 – 2101IronBy similarity
Metal bindingi212 – 2121IronBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.13.11.1. 4353.

Names & Taxonomyi

Protein namesi
Recommended name:
Catechol 1,2-dioxygenase (EC:1.13.11.1)
Alternative name(s):
1,2-CTD
Gene namesi
Name:catA
OrganismiRhodococcus opacus (Nocardia opaca)
Taxonomic identifieri37919 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 270›270Catechol 1,2-dioxygenasePRO_0000085084Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi632772.ROP_20870.

Structurei

Secondary structure

1
270
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi21 – 4222Combined sources
Helixi46 – 6116Combined sources
Helixi65 – 728Combined sources
Helixi74 – 8310Combined sources
Beta strandi106 – 1094Combined sources
Helixi116 – 1183Combined sources
Beta strandi121 – 1299Combined sources
Beta strandi131 – 1333Combined sources
Beta strandi140 – 1445Combined sources
Turni161 – 1644Combined sources
Beta strandi165 – 1695Combined sources
Beta strandi174 – 1818Combined sources
Helixi193 – 2008Combined sources
Beta strandi211 – 2166Combined sources
Beta strandi223 – 2297Combined sources
Turni233 – 2364Combined sources
Helixi245 – 2473Combined sources
Beta strandi259 – 2624Combined sources
Beta strandi265 – 2673Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HGIX-ray1.94A1-270[»]
3HHXX-ray2.00A1-270[»]
3HHYX-ray1.55A1-270[»]
3HJ8X-ray2.40A1-270[»]
3HJQX-ray2.00A1-270[»]
3HJSX-ray1.80A1-270[»]
3HKPX-ray1.85A1-270[»]
3I4VX-ray2.00A1-270[»]
3I4YX-ray1.85A1-270[»]
3I51X-ray1.80A1-270[»]
ProteinModelPortaliP95607.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP95607.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108QMY. Bacteria.
COG3485. LUCA.

Family and domain databases

Gene3Di2.60.130.10. 1 hit.
InterProiIPR007535. Catechol_dOase_N.
IPR012800. Cchol_dOase_actb.
IPR000627. Intradiol_dOase_C.
IPR015889. Intradiol_dOase_core.
[Graphical view]
PfamiPF00775. Dioxygenase_C. 1 hit.
PF04444. Dioxygenase_N. 1 hit.
[Graphical view]
SUPFAMiSSF49482. SSF49482. 1 hit.
TIGRFAMsiTIGR02438. catachol_actin. 1 hit.
PROSITEiPS00083. INTRADIOL_DIOXYGENAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P95607-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GSGSAATDKF KAERATADTS PERLAAIAKD ALGALNDVIL KHGVTYPEYR
60 70 80 90 100
VFKQWLIDVG EGGEWPLFLD VFIEHSVEEV LARSRKGTMG SIEGPYYIEN
110 120 130 140 150
SPELPSKCTL PMREEDEKIT PLVFSGQVTD LDGNGLAGAK VELWHADNDG
160 170 180 190 200
YYSQFAPHLP EWNLRGTIIA DEEGRYEITT IQPAPYQIPT DGPTGQFIEA
210 220 230 240 250
QNGHPWRPAH LHLIVSAPGK ESVTTQLYFK GGEWIDSDVA SATKPELILD
260 270
PKTGDDGKNY VTYNFVLDPA
Length:270
Mass (Da):29,704
Last modified:May 1, 1997 - v1
Checksum:iBCD5BE5B8365115A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99622 Genomic DNA. Translation: CAA67941.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99622 Genomic DNA. Translation: CAA67941.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HGIX-ray1.94A1-270[»]
3HHXX-ray2.00A1-270[»]
3HHYX-ray1.55A1-270[»]
3HJ8X-ray2.40A1-270[»]
3HJQX-ray2.00A1-270[»]
3HJSX-ray1.80A1-270[»]
3HKPX-ray1.85A1-270[»]
3I4VX-ray2.00A1-270[»]
3I4YX-ray1.85A1-270[»]
3I51X-ray1.80A1-270[»]
ProteinModelPortaliP95607.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi632772.ROP_20870.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4108QMY. Bacteria.
COG3485. LUCA.

Enzyme and pathway databases

BRENDAi1.13.11.1. 4353.

Miscellaneous databases

EvolutionaryTraceiP95607.

Family and domain databases

Gene3Di2.60.130.10. 1 hit.
InterProiIPR007535. Catechol_dOase_N.
IPR012800. Cchol_dOase_actb.
IPR000627. Intradiol_dOase_C.
IPR015889. Intradiol_dOase_core.
[Graphical view]
PfamiPF00775. Dioxygenase_C. 1 hit.
PF04444. Dioxygenase_N. 1 hit.
[Graphical view]
SUPFAMiSSF49482. SSF49482. 1 hit.
TIGRFAMsiTIGR02438. catachol_actin. 1 hit.
PROSITEiPS00083. INTRADIOL_DIOXYGENAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of catechol catabolic genes from Rhodococcus erythropolis 1CP."
    Eulberg D., Golovleva L.A., Schloemann M.
    J. Bacteriol. 179:370-381(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 113-132 AND 195-203.
    Strain: 1CP.

Entry informationi

Entry nameiCATA_RHOOP
AccessioniPrimary (citable) accession number: P95607
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: November 11, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.