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P95524 (DYR6_PROMI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydrofolate reductase type 6

EC=1.5.1.3
Alternative name(s):
Dihydrofolate reductase type VI
Gene names
Name:dhfrVI
Synonyms:dfrVI
Encoded onPlasmid pUK672
OrganismProteus mirabilis
Taxonomic identifier584 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus

Protein attributes

Sequence length157 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis By similarity.

Catalytic activity

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the dihydrofolate reductase family.

Contains 1 DHFR (dihydrofolate reductase) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 157157Dihydrofolate reductase type 6
PRO_0000186423

Regions

Domain2 – 156155DHFR

Sequences

Sequence LengthMass (Da)Tools
P95524 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: FE10DDF3724E7D27

FASTA15717,444
        10         20         30         40         50         60 
MKISLMAAVS ENGVIGSGLD IPWHVQGEQL LFKAMTYNQW LLVGRKTFDS MGKLPNRKYA 

        70         80         90        100        110        120 
VVTRSKIISN DPDVVYFASV ESALAYLNNA TAHIFVSGGG EIYKALIDQA DVIHLSVIHK 

       130        140        150 
HISGDVFFPP VPQGFKQTFE QSFSSNIDYT YQIWAKG 

« Hide

References

[1]"Nucleotide sequence of dihydrofolate reductase type VI."
Wylie B.A., Koornhof H.J.
J. Med. Microbiol. 35:214-218(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: J120.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z86002 Genomic DNA. Translation: CAB06660.1.

3D structure databases

ProteinModelPortalP95524.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00077; UER00158.

Family and domain databases

Gene3D3.40.430.10. 1 hit.
InterProIPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view]
PfamPF00186. DHFR_1. 1 hit.
[Graphical view]
PRINTSPR00070. DHFR.
SUPFAMSSF53597. SSF53597. 1 hit.
PROSITEPS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDYR6_PROMI
AccessionPrimary (citable) accession number: P95524
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: October 16, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways