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Reviewed, UniProtKB/Swiss-Prot P95524 (DYR6_PROMI)

Last modified November 25, 2008. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Dihydrofolate reductase type 6
    EC=1.5.1.3
Alternative name(s):
    Dihydrofolate reductase type VI
Gene names
Name: dhfrVI
Synonyms: dfrVI
Encoded onPlasmid pUK672
OrganismProteus mirabilis
Taxonomic identifier584 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus

Protein attributes

Sequence length157 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; tetrahydrofolate from dihydrofolate: step 1/1.

Subunit structure

Homodimer By similarity.

Miscellaneous

The reaction catalyzed by this enzyme represents an essential step for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.

Sequence similarities

Belongs to the dihydrofolate reductase family.

Contains 1 DHFR (dihydrofolate reductase) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 157157Dihydrofolate reductase type 6
PRO_0000186423

Regions

Domain2 – 156155DHFR

Sequences

Sequence LengthMass (Da)Tools
P95524-1 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: FE10DDF3724E7D27

FASTA15717,444
        10         20         30         40         50         60 
MKISLMAAVS ENGVIGSGLD IPWHVQGEQL LFKAMTYNQW LLVGRKTFDS MGKLPNRKYA 

        70         80         90        100        110        120 
VVTRSKIISN DPDVVYFASV ESALAYLNNA TAHIFVSGGG EIYKALIDQA DVIHLSVIHK 

       130        140        150 
HISGDVFFPP VPQGFKQTFE QSFSSNIDYT YQIWAKG 

« Hide

References

[1]"Nucleotide sequence of dihydrofolate reductase type VI."
Wylie B.A., Koornhof H.J.
J. Med. Microbiol. 35:214-218(1991) [PubMed: 1941991] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: J120.

Cross-references

Sequence databases

Z86002 Genomic DNA. Translation: CAB06660.1.

3D structure databases

HSSPHSSP built from PDB template 1DYR based on UniProtKB P16184.
ModBaseSearch...

Family and domain databases

InterProIPR012259. DHFR.
IPR001796. DHFR_reg.
[Graphical view]
PANTHERPTHR11549:SF1. DHFR. 1 hit.
PfamPF00186. DHFR_1. 1 hit.
[Graphical view]
PRINTSPR00070. DHFR.
PROSITEPS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDYR6_PROMI
AccessionPrimary (citable) accession number: P95524
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 25, 2008
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents