Reviewed, UniProtKB/Swiss-Prot P95477 (DCHS_PSEFL)

Names and origin

Protein names

Recommended name:
    Histidine decarboxylase
      Short name=HDC
    EC=4.1.1.22

Gene names

Name:	hdc
Synonyms:	pmsA

Organism

Pseudomonas fluorescens

Taxonomic identifier

294 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	405 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidine = histamine + CO2. HAMAP MF_00609
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_00609
Pathway	Siderophore biosynthesis; pseudomonine biosynthesis. HAMAP MF_00609
Subunit structure	Homotetramer By similarity. HAMAP MF_00609
Sequence similarities	Belongs to the group II decarboxylase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Gene Ontology (GO)
Biological process	carboxylic acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	histidine decarboxylase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 405	405	Histidine decarboxylase HAMAP MF_00609		PRO_0000146959
Amino acid modifications
	Modified residue	234	1	N6-(pyridoxal phosphate)lysine Potential

Sequences

	Sequence		Length	Mass (Da)
	P95477-1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 801C199C559731D9	FASTA	405	45,727
	10 20 30 40 50 60 MTLSPADQSK LEGFWQHCVT HQYFNIGYPE SADFDYSQLH RFLQFSINNL LGTGNEYSNY 70 80 90 100 110 120 LLNSFDFEKD VMTYFAELFN IALEDSWGYV TNGGTEGNMF GCYLGRELFP DGTLYYSKDT 130 140 150 160 170 180 HYSVAKIVKL LRIKCRAVES LPNGEIDYDD LMAKITADQE RHPIIFANIG TTMRGALDNI 190 200 210 220 230 240 VTIQQRLQQA GIARHDYYLH ADAALSGMIL PFVDHPQPFS FADGIDSICV SGHKMIGSPI 250 260 270 280 290 300 PCGIVVAKRN NVARISVEVD YIRAHDKTIS GSRNGHTPLM MWAALRSYSW AEWRHRIKHS 310 320 330 340 350 360 LDTAQYAVDR FQASGIDAWR NENSITVVFP CPSERIATKY CLATSGNSAH LITTPHHHDC 370 380 390 400 SMIDALIDEV VAEAQLNTLR SKRAFTEQTV VERLPAASFN LRTHY

References

[1]

"Analysis of the pmsCEAB gene cluster involved in biosynthesis of salicylic acid and the siderophore pseudomonine in the biocontrol strain Pseudomonas fluorescens WCS374." Mercado-Blanco J., van der Drift K.M.G.M., Olsson P.E., Thomas-Oates J.E., Van Loon L.C., Bakker P.A.H.M. J. Bacteriol. 183:1909-1920(2001) [PubMed: 11222588] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: WCS374.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y09356 Genomic DNA. Translation: CAA70530.1.
3D structure databases
SMR	P95477. Positions 65-315.
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.1.1.22. 329.
Family and domain databases
HAMAP	MF_00609. Pyridoxal_decarbox. [Tree]
InterPro	IPR002129. PyrdxlP-dep_de-COase. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR021115. Pyridoxal-P_BS. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11999. Pyridoxal_deC. 1 hit.
Pfam	PF00282. Pyridoxal_deC. 1 hit. [Graphical view]
PROSITE	PS00392. DDC_GAD_HDC_YDC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCHS_PSEFL

Accession

Primary (citable) accession number: P95477

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 13, 2002
Last sequence update:	May 1, 1997
Last modified:	February 9, 2010
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)