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P95329

- MASY_MYXXD

UniProt

P95329 - MASY_MYXXD

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Protein
Malate synthase
Gene
mls, MXAN_6441
Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei172 – 1721Proton acceptor By similarity
Active sitei452 – 4521Proton donor By similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyciMXAN246197:GIWU-6390-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase (EC:2.3.3.9)
Gene namesi
Name:mls
Ordered Locus Names:MXAN_6441
OrganismiMyxococcus xanthus (strain DK 1622)
Taxonomic identifieri246197 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
ProteomesiUP000002402: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 541541Malate synthase
PRO_0000166876Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246197.MXAN_6441.

Structurei

3D structure databases

ProteinModelPortaliP95329.

Family & Domainsi

Sequence similaritiesi

Belongs to the malate synthase family.

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000238464.
KOiK01638.
OMAiSIWQWIR.
OrthoDBiEOG69WFFX.

Family and domain databases

InterProiIPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001363. Malate_synth. 1 hit.
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P95329-1 [UniParc]FASTAAdd to Basket

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MSDQAPSVKP PAFGPGVVVK GTWHPDYAEV LTPEALEFVA KLARNFGERR    50
LALLERRKTV QAAWSKGARP HFLPETKAVR EGDWTVAPLP ADLQDRRVEI 100
TGPVDRKMVI NALNSGANVF MADFEDANSP TWDNVVRGQI NLRDAVRGTI 150
SFTAENGKHY ALNPKRAVLF VRPRGWHLPE RHIEIDGKPI SGSLLDFGLF 200
FFHNAREQLA RGTGPYFYLP KMQSHLEARL WNDVFHLAQA ELGIPRGTIK 250
ATVLIETLPA AFEMDEILYE LREHSAGLNC GRWDYIFSFI KTLQSDTRVV 300
LPDRGQVTMD KAFLNAYSQL LIQTCHRRNV HAMGGMAAFI PIKGDAAAND 350
AVMDKVRADK LREVKNGHDG TWVAHPGLVE IARDIFDSHM KGPNQLSNKR 400
EDVKIGEAEL LKVPSGTRTE EGLRHNIRVG IQYTAAWLGG LGCVPLYNLM 450
EDAATAEISR AQVWQWIHHG ASLEDGRKVT LTLFRDALGE EMGRLEKEGA 500
KERYGAAHLE RARVLFEQLS TAGTFEDFLT LPAYDALEAQ R 541
Length:541
Mass (Da):60,509
Last modified:September 19, 2006 - v2
Checksum:iE25A8236686AA626
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951D → E in AAB97829. 1 Publication
Sequence conflicti385 – 3851I → L in AAB97829. 1 Publication
Sequence conflicti398 – 3981N → D in AAB97829. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF013216 Genomic DNA. Translation: AAB97829.1.
CP000113 Genomic DNA. Translation: ABF86861.1.
RefSeqiYP_634565.1. NC_008095.1.

Genome annotation databases

EnsemblBacteriaiABF86861; ABF86861; MXAN_6441.
GeneIDi4105164.
KEGGimxa:MXAN_6441.
PATRICi22655385. VBIMyxXan43560_6336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF013216 Genomic DNA. Translation: AAB97829.1 .
CP000113 Genomic DNA. Translation: ABF86861.1 .
RefSeqi YP_634565.1. NC_008095.1.

3D structure databases

ProteinModelPortali P95329.
ModBasei Search...

Protein-protein interaction databases

STRINGi 246197.MXAN_6441.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF86861 ; ABF86861 ; MXAN_6441 .
GeneIDi 4105164.
KEGGi mxa:MXAN_6441.
PATRICi 22655385. VBIMyxXan43560_6336.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000238464.
KOi K01638.
OMAi SIWQWIR.
OrthoDBi EOG69WFFX.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci MXAN246197:GIWU-6390-MONOMER.

Family and domain databases

InterProi IPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001363. Malate_synth. 1 hit.
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01344. malate_syn_A. 1 hit.
PROSITEi PS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Myxococcus xanthus fumarate hydratase, major proteosome subunit, and acyl-CoA oxidase genes."
    Salmi D., Creighton C., Youderian P.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DK 1622.

Entry informationi

Entry nameiMASY_MYXXD
AccessioniPrimary (citable) accession number: P95329
Secondary accession number(s): Q1CYF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 19, 2006
Last modified: June 11, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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