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Protein

Malate synthase

Gene

mls

Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.

Pathwayi: glyoxylate cycle

This protein is involved in step 2 of the subpathway that synthesizes (S)-malate from isocitrate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Malate synthase (mls)
This subpathway is part of the pathway glyoxylate cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-malate from isocitrate, the pathway glyoxylate cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei172Proton acceptorBy similarity1
Active sitei452Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processGlyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyciMXAN246197:G1G53-6329-MONOMER
UniPathwayiUPA00703; UER00720

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase (EC:2.3.3.9)
Gene namesi
Name:mls
Ordered Locus Names:MXAN_6441
OrganismiMyxococcus xanthus (strain DK 1622)
Taxonomic identifieri246197 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
Proteomesi
  • UP000002402 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001668761 – 541Malate synthaseAdd BLAST541

Proteomic databases

PRIDEiP95329

Interactioni

Protein-protein interaction databases

STRINGi246197.MXAN_6441

Structurei

3D structure databases

ProteinModelPortaliP95329
SMRiP95329
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the malate synthase family.Curated

Phylogenomic databases

eggNOGiENOG4107QP3 Bacteria
COG2225 LUCA
HOGENOMiHOG000238464
KOiK01638
OMAiETAHIRA
OrthoDBiPOG091H05S7

Family and domain databases

CDDicd00727 malate_synt_A, 1 hit
InterProiView protein in InterPro
IPR011076 Malate_synth-like_sf
IPR006252 Malate_synthA
IPR001465 Malate_synthase
IPR019830 Malate_synthase_CS
PANTHERiPTHR42902 PTHR42902, 1 hit
PfamiView protein in Pfam
PF01274 Malate_synthase, 1 hit
PIRSFiPIRSF001363 Malate_synth, 1 hit
SUPFAMiSSF51645 SSF51645, 1 hit
TIGRFAMsiTIGR01344 malate_syn_A, 1 hit
PROSITEiView protein in PROSITE
PS00510 MALATE_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

P95329-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDQAPSVKP PAFGPGVVVK GTWHPDYAEV LTPEALEFVA KLARNFGERR
60 70 80 90 100
LALLERRKTV QAAWSKGARP HFLPETKAVR EGDWTVAPLP ADLQDRRVEI
110 120 130 140 150
TGPVDRKMVI NALNSGANVF MADFEDANSP TWDNVVRGQI NLRDAVRGTI
160 170 180 190 200
SFTAENGKHY ALNPKRAVLF VRPRGWHLPE RHIEIDGKPI SGSLLDFGLF
210 220 230 240 250
FFHNAREQLA RGTGPYFYLP KMQSHLEARL WNDVFHLAQA ELGIPRGTIK
260 270 280 290 300
ATVLIETLPA AFEMDEILYE LREHSAGLNC GRWDYIFSFI KTLQSDTRVV
310 320 330 340 350
LPDRGQVTMD KAFLNAYSQL LIQTCHRRNV HAMGGMAAFI PIKGDAAAND
360 370 380 390 400
AVMDKVRADK LREVKNGHDG TWVAHPGLVE IARDIFDSHM KGPNQLSNKR
410 420 430 440 450
EDVKIGEAEL LKVPSGTRTE EGLRHNIRVG IQYTAAWLGG LGCVPLYNLM
460 470 480 490 500
EDAATAEISR AQVWQWIHHG ASLEDGRKVT LTLFRDALGE EMGRLEKEGA
510 520 530 540
KERYGAAHLE RARVLFEQLS TAGTFEDFLT LPAYDALEAQ R
Length:541
Mass (Da):60,509
Last modified:September 19, 2006 - v2
Checksum:iE25A8236686AA626
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95D → E in AAB97829 (Ref. 1) Curated1
Sequence conflicti385I → L in AAB97829 (Ref. 1) Curated1
Sequence conflicti398N → D in AAB97829 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013216 Genomic DNA Translation: AAB97829.1
CP000113 Genomic DNA Translation: ABF86861.1
RefSeqiWP_011556373.1, NC_008095.1

Genome annotation databases

EnsemblBacteriaiABF86861; ABF86861; MXAN_6441
KEGGimxa:MXAN_6441

Similar proteinsi

Entry informationi

Entry nameiMASY_MYXXD
AccessioniPrimary (citable) accession number: P95329
Secondary accession number(s): Q1CYF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 19, 2006
Last modified: May 23, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health