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P95329

- MASY_MYXXD

UniProt

P95329 - MASY_MYXXD

Protein

Malate synthase

Gene

mls

Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (19 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei172 – 1721Proton acceptorBy similarity
    Active sitei452 – 4521Proton donorBy similarity

    GO - Molecular functioni

    1. malate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-UniPathway
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Enzyme and pathway databases

    BioCyciMXAN246197:GIWU-6390-MONOMER.
    UniPathwayiUPA00703; UER00720.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate synthase (EC:2.3.3.9)
    Gene namesi
    Name:mls
    Ordered Locus Names:MXAN_6441
    OrganismiMyxococcus xanthus (strain DK 1622)
    Taxonomic identifieri246197 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
    ProteomesiUP000002402: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 541541Malate synthasePRO_0000166876Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi246197.MXAN_6441.

    Structurei

    3D structure databases

    ProteinModelPortaliP95329.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the malate synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG2225.
    HOGENOMiHOG000238464.
    KOiK01638.
    OMAiSIWQWIR.
    OrthoDBiEOG69WFFX.

    Family and domain databases

    InterProiIPR011076. Malate_synth-like.
    IPR006252. Malate_synthA.
    IPR001465. Malate_synthase.
    IPR019830. Malate_synthase_CS.
    [Graphical view]
    PfamiPF01274. Malate_synthase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001363. Malate_synth. 1 hit.
    SUPFAMiSSF51645. SSF51645. 1 hit.
    TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
    PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P95329-1 [UniParc]FASTAAdd to Basket

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    MSDQAPSVKP PAFGPGVVVK GTWHPDYAEV LTPEALEFVA KLARNFGERR    50
    LALLERRKTV QAAWSKGARP HFLPETKAVR EGDWTVAPLP ADLQDRRVEI 100
    TGPVDRKMVI NALNSGANVF MADFEDANSP TWDNVVRGQI NLRDAVRGTI 150
    SFTAENGKHY ALNPKRAVLF VRPRGWHLPE RHIEIDGKPI SGSLLDFGLF 200
    FFHNAREQLA RGTGPYFYLP KMQSHLEARL WNDVFHLAQA ELGIPRGTIK 250
    ATVLIETLPA AFEMDEILYE LREHSAGLNC GRWDYIFSFI KTLQSDTRVV 300
    LPDRGQVTMD KAFLNAYSQL LIQTCHRRNV HAMGGMAAFI PIKGDAAAND 350
    AVMDKVRADK LREVKNGHDG TWVAHPGLVE IARDIFDSHM KGPNQLSNKR 400
    EDVKIGEAEL LKVPSGTRTE EGLRHNIRVG IQYTAAWLGG LGCVPLYNLM 450
    EDAATAEISR AQVWQWIHHG ASLEDGRKVT LTLFRDALGE EMGRLEKEGA 500
    KERYGAAHLE RARVLFEQLS TAGTFEDFLT LPAYDALEAQ R 541
    Length:541
    Mass (Da):60,509
    Last modified:September 19, 2006 - v2
    Checksum:iE25A8236686AA626
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti95 – 951D → E in AAB97829. 1 PublicationCurated
    Sequence conflicti385 – 3851I → L in AAB97829. 1 PublicationCurated
    Sequence conflicti398 – 3981N → D in AAB97829. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF013216 Genomic DNA. Translation: AAB97829.1.
    CP000113 Genomic DNA. Translation: ABF86861.1.
    RefSeqiYP_634565.1. NC_008095.1.

    Genome annotation databases

    EnsemblBacteriaiABF86861; ABF86861; MXAN_6441.
    GeneIDi4105164.
    KEGGimxa:MXAN_6441.
    PATRICi22655385. VBIMyxXan43560_6336.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF013216 Genomic DNA. Translation: AAB97829.1 .
    CP000113 Genomic DNA. Translation: ABF86861.1 .
    RefSeqi YP_634565.1. NC_008095.1.

    3D structure databases

    ProteinModelPortali P95329.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246197.MXAN_6441.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF86861 ; ABF86861 ; MXAN_6441 .
    GeneIDi 4105164.
    KEGGi mxa:MXAN_6441.
    PATRICi 22655385. VBIMyxXan43560_6336.

    Phylogenomic databases

    eggNOGi COG2225.
    HOGENOMi HOG000238464.
    KOi K01638.
    OMAi SIWQWIR.
    OrthoDBi EOG69WFFX.

    Enzyme and pathway databases

    UniPathwayi UPA00703 ; UER00720 .
    BioCyci MXAN246197:GIWU-6390-MONOMER.

    Family and domain databases

    InterProi IPR011076. Malate_synth-like.
    IPR006252. Malate_synthA.
    IPR001465. Malate_synthase.
    IPR019830. Malate_synthase_CS.
    [Graphical view ]
    Pfami PF01274. Malate_synthase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001363. Malate_synth. 1 hit.
    SUPFAMi SSF51645. SSF51645. 1 hit.
    TIGRFAMsi TIGR01344. malate_syn_A. 1 hit.
    PROSITEi PS00510. MALATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Myxococcus xanthus fumarate hydratase, major proteosome subunit, and acyl-CoA oxidase genes."
      Salmi D., Creighton C., Youderian P.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DK 1622.

    Entry informationi

    Entry nameiMASY_MYXXD
    AccessioniPrimary (citable) accession number: P95329
    Secondary accession number(s): Q1CYF8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: September 19, 2006
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3